Stroke is a main cause of death and disability worldwide.The ability of the brain to selfrepair in the acute and chronic phases after stroke is minimal;however,promising stem cell-based interventions are emerging that...Stroke is a main cause of death and disability worldwide.The ability of the brain to selfrepair in the acute and chronic phases after stroke is minimal;however,promising stem cell-based interventions are emerging that may give substantial and possibly complete recovery of brain function after stroke.Many animal models and clinical trials have demonstrated that neural stem cells(NSCs)in the central nervous system can orchestrate neurological repair through nerve regeneration,neuron polarization,axon pruning,neurite outgrowth,repair of myelin,and remodeling of the microenvironment and brain networks.Compared with other types of stem cells,NSCs have unique advantages in cell replacement,paracrine action,inflammatory regulation and neuroprotection.Our review summarizes NSC origins,characteristics,therapeutic mechanisms and repair processes,then highlights current research findings and clinical evidence for NSC therapy.These results may be helpful to inform the direction of future stroke research and to guide clinical decision-making.展开更多
Increasing evidence has revealed that the activation of the JNK pathway participates In apoptosis o1 nerve cells and neurological function recovery after traumatic brain injury. However, which genes inI the JNK family...Increasing evidence has revealed that the activation of the JNK pathway participates In apoptosis o1 nerve cells and neurological function recovery after traumatic brain injury. However, which genes inI the JNK family are activated and their role in traumatic brain injury remain unclear. Therefore, in this study, in situ end labeling, reverse transcription-PCR and neurological function assessment were adopted to investigate the alteration of JNK1, JNK2 and JNK3 gene expression in cerebral injured rats, and their role in celt apoptosis and neurological function restoration. Results showed that JNK3 expression significantly decreased at 1 and 6 hours and 1 and 7 days post injury, but that JNK1 and JNK2 expression remained unchanged. In addition, the number of apoptotic nerve cells surrounding the injured cerebral cortex gradually reduced over time post injury. The Neurological Severity Scores gradually decreased over 1,3, 5, 14 and 28 days post injury. These findings suggested that JNK3 expression was downregulated at early stages of brain injury, which may be associated with apoptosis of nerve cells. Downregulation of JNK3 expression may promote the recovery of neurological function following traumatic brain injury.展开更多
Objective:To analyze the effect of ventriculoperitoneal shunt on the recovery of brain function in children with hydrocephalus.Methods:The clinical data of 40 children with hydrocephalus were retrospectively analyzed....Objective:To analyze the effect of ventriculoperitoneal shunt on the recovery of brain function in children with hydrocephalus.Methods:The clinical data of 40 children with hydrocephalus were retrospectively analyzed.Ventriculoperitoneal shunt was performed with 9003 shunt tube and P.S.Shunt tube,B.C.E.shunt tube.Electroencephalogram(EEG),and brain CT/MRI were performed before and after surgery,and postoperative follow-up was carried out to observe the therapeutic effect.Results:In this study,there were seven cases of intracranial injury,seven cases of congenital hydrocephalus,11 cases of ventricular end obstruction,three cases of abdominal end obstruction,nine cases complicated with bacterial infection,and 3 cases of shunt entering the scrotum.The prognosis of all the children was good,and there were no significant changes in eight cases.Conclusion:Ventriculoperitoneal shunt is effective in the treatment of children with hydrocephalus.展开更多
基金This work was supported by the National Natural Science Foundation of China,No.81471308(to JL)Program of China National Health Commission and National Medical Products Administration(NMPA),No.CMR-20161129-1003(to JL)+1 种基金Liaoning Province Excellent Talent Program Project,No.XLYC1902031(to JL)Dalian Innovation Fund,No.2018J11CY025(to JL).
文摘Stroke is a main cause of death and disability worldwide.The ability of the brain to selfrepair in the acute and chronic phases after stroke is minimal;however,promising stem cell-based interventions are emerging that may give substantial and possibly complete recovery of brain function after stroke.Many animal models and clinical trials have demonstrated that neural stem cells(NSCs)in the central nervous system can orchestrate neurological repair through nerve regeneration,neuron polarization,axon pruning,neurite outgrowth,repair of myelin,and remodeling of the microenvironment and brain networks.Compared with other types of stem cells,NSCs have unique advantages in cell replacement,paracrine action,inflammatory regulation and neuroprotection.Our review summarizes NSC origins,characteristics,therapeutic mechanisms and repair processes,then highlights current research findings and clinical evidence for NSC therapy.These results may be helpful to inform the direction of future stroke research and to guide clinical decision-making.
文摘Increasing evidence has revealed that the activation of the JNK pathway participates In apoptosis o1 nerve cells and neurological function recovery after traumatic brain injury. However, which genes inI the JNK family are activated and their role in traumatic brain injury remain unclear. Therefore, in this study, in situ end labeling, reverse transcription-PCR and neurological function assessment were adopted to investigate the alteration of JNK1, JNK2 and JNK3 gene expression in cerebral injured rats, and their role in celt apoptosis and neurological function restoration. Results showed that JNK3 expression significantly decreased at 1 and 6 hours and 1 and 7 days post injury, but that JNK1 and JNK2 expression remained unchanged. In addition, the number of apoptotic nerve cells surrounding the injured cerebral cortex gradually reduced over time post injury. The Neurological Severity Scores gradually decreased over 1,3, 5, 14 and 28 days post injury. These findings suggested that JNK3 expression was downregulated at early stages of brain injury, which may be associated with apoptosis of nerve cells. Downregulation of JNK3 expression may promote the recovery of neurological function following traumatic brain injury.
文摘Objective:To analyze the effect of ventriculoperitoneal shunt on the recovery of brain function in children with hydrocephalus.Methods:The clinical data of 40 children with hydrocephalus were retrospectively analyzed.Ventriculoperitoneal shunt was performed with 9003 shunt tube and P.S.Shunt tube,B.C.E.shunt tube.Electroencephalogram(EEG),and brain CT/MRI were performed before and after surgery,and postoperative follow-up was carried out to observe the therapeutic effect.Results:In this study,there were seven cases of intracranial injury,seven cases of congenital hydrocephalus,11 cases of ventricular end obstruction,three cases of abdominal end obstruction,nine cases complicated with bacterial infection,and 3 cases of shunt entering the scrotum.The prognosis of all the children was good,and there were no significant changes in eight cases.Conclusion:Ventriculoperitoneal shunt is effective in the treatment of children with hydrocephalus.
