In order to numerically evaluate the acoustic characteristics of liquid rocket engine thrust chambers by means of a computational fluid dynamics method, a mathematical model of an artificial constant-volume bomb is pr...In order to numerically evaluate the acoustic characteristics of liquid rocket engine thrust chambers by means of a computational fluid dynamics method, a mathematical model of an artificial constant-volume bomb is proposed in this paper. A localized pressure pulse with a very high amplitude can be imposed on specified regions in a combustion chamber, the numerical procedure of which is described. Pressure oscillations actuated by the released constant-volume bomb can then be analyzed via Fast Fourier Transformation（FFT）, and their modes can be identified according to the theoretical acoustic eigenfrequencies of the thrust chamber. The damping performances of the corresponding acoustic modes are evaluated by the half-power bandwidth method. The predicted acoustic characteristics and their damping for a special engine combustor agree well with the experimental data, validating the mathematical model and its numerical procedures. A small-thrust liquid rocket engine chamber is then analyzed by the present model. The First Longitudinal（1L） acoustic mode can be excited easily and is hard to be damped. The axial position of the central constantvolume bomb has little influence on the amplitude and damping capacity of the First Radial（1R） and 1L acoustic modes. Tangential acoustic modes can only be triggered by an off-centered constant-volume bomb, among which the First Tangential（1T） mode is the strongest and regarded as the most harmful one. The amplitude of the 1L acoustic mode is smaller, but its damping factor is larger, as a constant-volume bomb is imposed approaching the injector face. These results are contributed to evaluate the acoustic characteristics and their damping of the combustion chamber.展开更多
Background:Since the 1970 s,terrorist bombings in subways have been frequently occurring worldwide.To cope with this threat and to provide medical response countermeasures,we analyzed the characteristics of subway bom...Background:Since the 1970 s,terrorist bombings in subways have been frequently occurring worldwide.To cope with this threat and to provide medical response countermeasures,we analyzed the characteristics of subway bombing terrorist attacks and used the Haddon matrix to explore medical response strategies.Methods:First,we analyzed 111 subway bombings from 1970 to 2017 recorded in the Global Terrorism Database to provide a reference for the strategy exploration.Then,we convened an expert panel to use the Haddon matrix to explore the medical response strategies to subway bombings.Results:In recent decades,at least one bombing attack occurs every 3 years.Summarized by the Haddon matrix,the influencing factors of medical responses to conventional subway bombings include the adequacy of first-aid kits and the medical evacuation equipment,the traffic conditions affecting the evacuation,the continuity and stability of communication,as well as the factors exclusively attributed to dirty bomb attacks in subways,such as ionizing radiation protection capabilities,the structure of the radiation sickness treatment network based on the subway lines,and the disposal of radioactive sewage.These factors form the basis of the strategy discussion.Conclusions:Since subway bombings are long-term threats,it is necessary to have proper medical response preparation.Based on the Haddon matrix,we explored the medical response strategies for terrorist subway bombings,especially dirty bomb attacks.Haddon matrix can help policymakers systematically find the most important factors,which makes the preparations of the response more efficient.展开更多
Natural gas is a promising alternative fuel for the internal combustion engine,and natural gas engine has become an efficient and feasible measure to deal with the energy shortage and climate change.Since the laminar ...Natural gas is a promising alternative fuel for the internal combustion engine,and natural gas engine has become an efficient and feasible measure to deal with the energy shortage and climate change.Since the laminar flame characteristics are the foundation of the turbulent flame,the laminar flame characteristics of natural gas have a significant impact on the combustion status and efficiency of the engine.A visual constant volume bomb was used to study the influence of the gas components,different excess air coefficient(λ),and initial conditions on the laminar combustion characteristics of natural gas.The experimental results showed that when the initial pressure and temperature were 0.1 MPa and 300 K respectively,compared to propane,ethane had a remarkable influence on the equivalent-combustion laminar-combustion-speed,with an average increase of approximately 5.1%for every 2.5%increase in the ethane proportion.The laminar combustion velocity of the natural gas under different excess air coefficients had a maximum value at aboutλ=1.0,and the Markstein length of the flame decreased with the increase of theλ.The increase in the initial pressure of the mixture resulted in a decrease in the equivalent-combustion laminar-combustion-speed of the flame,a significant decrease in the Markstein length.The increase of the initial temperature of the mixture led to a rapid increase of the equivalent-combustion laminar-combustion-speed,but the effect on the flame Markstein length was not dominant.展开更多
To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blas...To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast loading.First,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage test.Second,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation method.Finally,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact block.The calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the model.The residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged panel.The results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.展开更多
Using model like hot air bloom with zero-weighted membrane wrapped hot air, surrounded by cold air, this paper sets up a partial differential equation (PDE) of motion of mushroom cloud by modifying Navier-Stokes (N-S)...Using model like hot air bloom with zero-weighted membrane wrapped hot air, surrounded by cold air, this paper sets up a partial differential equation (PDE) of motion of mushroom cloud by modifying Navier-Stokes (N-S) equations. The obtained equation is a vector PDE. It states that the derivative of velocity is with respect to time proportions to the gradient of temperature with respect to trace. Its solution is obtained by the method of separating variables for scalar function. These results have been compared with well agreement with literatures. Highlight: The Principle of Minimum Energy Release (PMER) is used to prove the pulse-mode of explosion of nuclear weapon, as great Earthquake, and optimum path problems.展开更多
PIT tests are usually performed when a mass distribution of High Explosive(H.E) projectile fragments is required. This paper shows the underwater detonation effects of 60 mm, M90 H.E. mortar bomb filled with Comp. B o...PIT tests are usually performed when a mass distribution of High Explosive(H.E) projectile fragments is required. This paper shows the underwater detonation effects of 60 mm, M90 H.E. mortar bomb filled with Comp. B on cylindrical concrete structure(concrete pipe closed at one end-similar to a PIT test)which is 2 m high(inner height) with inner diameter of also 2 m. Thickness of both wall and bottom of a pipe is 0.35 m. Detailed characteristics of concrete which is used for manufacturing of a pipe are specified. Mortar bomb is submerged directly in to the water(no free airspace around the bomb) with the nose pointing to the bottom of a pipe. Number and mass of fragments after detonation are presented by table and photographs. Fragments of dummy fuze, through which blasting cap was protruded, are collected and reassembled to form a shape of a fuze after detonation where expanding of fuze material due to a detonation products is visualized. After underwater detonation, detonation of the same mortar bomb is performed in an empty pipe and the effects of this kind of detonation are observed. Distance at which fragments generated from submerged mortar bomb will not reach concrete pipes wall is also determined.展开更多
The synoptic situation and mesoscale structure of an explosive extratropical cyclone over the Northwestern Pacific in March 2007 are investigated through weather station observations and data reanalysis. The cyclone i...The synoptic situation and mesoscale structure of an explosive extratropical cyclone over the Northwestern Pacific in March 2007 are investigated through weather station observations and data reanalysis. The cyclone is located beneath the poleward side of the exit of a 200 hPa jet, which is a strong divergent region aloft. At mid-level, the cyclone lies on the downstream side of a well-developed trough, where a strong ascending motion frequently occurs. Cross-section analyses with weather station data show that the cyclone has a warm and moist core. A ‘nose' of the cold front, which is characterized by a low-level protruding structure in the equivalent potential temperature field, forms when the cyclone moves offshore. This ‘nose' structure is hypothesized to have been caused by the heating effect of the Kuroshio Current. Two low-level jet streams are also identified on the western and eastern sides of the cold front. The western jet conveys cold and dry air at 800–900 hPa. The wind in the northern part is northeasterly, and the wind in the southern part is northwesterly. By contrast, the eastern jet carries warm and moist air into the cyclone system, ascending northward from 900 hPa to 600–700 hPa. The southern part is dominated by the southerly wind, and the wind in the northern part is southwesterly. The eastern and western jets significantly increase the air temperature and moisture contrast in the vicinity of the cold front. This increase could play an important role in improving the rapid cyclogenesis process.展开更多
BACKGROUND The carcinogenesis of stomach adenocarcinoma(STAD)involves many different molecules and multiple pathways,including the NOTCH signaling pathway.As a key factor that functions as a critical link in the NOTCH...BACKGROUND The carcinogenesis of stomach adenocarcinoma(STAD)involves many different molecules and multiple pathways,including the NOTCH signaling pathway.As a key factor that functions as a critical link in the NOTCH pathway,mind bomb 1(MIB1)is upregulated in various tumors and has been reported to promote cell metastasis and invasion.However,studies on the role of MIB1 in STAD are limited.Here,we evaluated the prognostic value of MIB1 in STAD and its association with immune infiltration and copy number variation.AIM To elucidate the relationship between MIB1 gene and gastric cancer(GC)and provide a new idea for the treatment of GC.METHODS We identified mutations in the MIB1 gene by searching the cBioPortal database and then analyzed their relationship with the overall survival rate and diseasefree survival rate using the Kaplan-Meier method.The Cancer Genome Atlas(TCGA)database provided transcript levels for MIB1 in STADs and normal tissues.As a method of distinguishing the STAD tissues from adjacent normal tissues,a receiver operating characteristic(ROC)curve was generated.Kaplan-Meier plotter was used to determine the effect of MIB1 expression on survival.Based on the LinkedOmics database,we were able to identify the coexpressed genes of the MIB1 gene,the top 50 positively correlated genes,and the top 50 negatively correlated genes.STRING was used to construct protein-protein interaction networks related to the MIB1 gene.An analysis of functional enrichment was carried out using the R package“Cluster Profiler”.The relationships between mRNA expression of MIB1 and immune infiltrates were assessed by Tumor IMmune Estimation Resource(TIMER)and the“GSVA package”in R.RESULTS According to the cBioPortal database,the MIB1 mutation rate in 287 patients in the TCGA dataset was approximately 6%.Kaplan-Meier survival analysis showed that patients with STAD in the mutated group had a worse prognosis than those in the unmutated group(P=0.0156).There was a significant upregulation of MIB1 expression in STAD tissues展开更多
基金Financial support from the National Natural Science Foundation of China (Nos.51676111 and 11628206)
文摘In order to numerically evaluate the acoustic characteristics of liquid rocket engine thrust chambers by means of a computational fluid dynamics method, a mathematical model of an artificial constant-volume bomb is proposed in this paper. A localized pressure pulse with a very high amplitude can be imposed on specified regions in a combustion chamber, the numerical procedure of which is described. Pressure oscillations actuated by the released constant-volume bomb can then be analyzed via Fast Fourier Transformation（FFT）, and their modes can be identified according to the theoretical acoustic eigenfrequencies of the thrust chamber. The damping performances of the corresponding acoustic modes are evaluated by the half-power bandwidth method. The predicted acoustic characteristics and their damping for a special engine combustor agree well with the experimental data, validating the mathematical model and its numerical procedures. A small-thrust liquid rocket engine chamber is then analyzed by the present model. The First Longitudinal（1L） acoustic mode can be excited easily and is hard to be damped. The axial position of the central constantvolume bomb has little influence on the amplitude and damping capacity of the First Radial（1R） and 1L acoustic modes. Tangential acoustic modes can only be triggered by an off-centered constant-volume bomb, among which the First Tangential（1T） mode is the strongest and regarded as the most harmful one. The amplitude of the 1L acoustic mode is smaller, but its damping factor is larger, as a constant-volume bomb is imposed approaching the injector face. These results are contributed to evaluate the acoustic characteristics and their damping of the combustion chamber.
文摘Background:Since the 1970 s,terrorist bombings in subways have been frequently occurring worldwide.To cope with this threat and to provide medical response countermeasures,we analyzed the characteristics of subway bombing terrorist attacks and used the Haddon matrix to explore medical response strategies.Methods:First,we analyzed 111 subway bombings from 1970 to 2017 recorded in the Global Terrorism Database to provide a reference for the strategy exploration.Then,we convened an expert panel to use the Haddon matrix to explore the medical response strategies to subway bombings.Results:In recent decades,at least one bombing attack occurs every 3 years.Summarized by the Haddon matrix,the influencing factors of medical responses to conventional subway bombings include the adequacy of first-aid kits and the medical evacuation equipment,the traffic conditions affecting the evacuation,the continuity and stability of communication,as well as the factors exclusively attributed to dirty bomb attacks in subways,such as ionizing radiation protection capabilities,the structure of the radiation sickness treatment network based on the subway lines,and the disposal of radioactive sewage.These factors form the basis of the strategy discussion.Conclusions:Since subway bombings are long-term threats,it is necessary to have proper medical response preparation.Based on the Haddon matrix,we explored the medical response strategies for terrorist subway bombings,especially dirty bomb attacks.Haddon matrix can help policymakers systematically find the most important factors,which makes the preparations of the response more efficient.
基金The financial support is provided by the National Key R&D Program of China(2022YFE0100100)。
文摘Natural gas is a promising alternative fuel for the internal combustion engine,and natural gas engine has become an efficient and feasible measure to deal with the energy shortage and climate change.Since the laminar flame characteristics are the foundation of the turbulent flame,the laminar flame characteristics of natural gas have a significant impact on the combustion status and efficiency of the engine.A visual constant volume bomb was used to study the influence of the gas components,different excess air coefficient(λ),and initial conditions on the laminar combustion characteristics of natural gas.The experimental results showed that when the initial pressure and temperature were 0.1 MPa and 300 K respectively,compared to propane,ethane had a remarkable influence on the equivalent-combustion laminar-combustion-speed,with an average increase of approximately 5.1%for every 2.5%increase in the ethane proportion.The laminar combustion velocity of the natural gas under different excess air coefficients had a maximum value at aboutλ=1.0,and the Markstein length of the flame decreased with the increase of theλ.The increase in the initial pressure of the mixture resulted in a decrease in the equivalent-combustion laminar-combustion-speed of the flame,a significant decrease in the Markstein length.The increase of the initial temperature of the mixture led to a rapid increase of the equivalent-combustion laminar-combustion-speed,but the effect on the flame Markstein length was not dominant.
文摘To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast loading.First,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage test.Second,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation method.Finally,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact block.The calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the model.The residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged panel.The results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.
文摘Using model like hot air bloom with zero-weighted membrane wrapped hot air, surrounded by cold air, this paper sets up a partial differential equation (PDE) of motion of mushroom cloud by modifying Navier-Stokes (N-S) equations. The obtained equation is a vector PDE. It states that the derivative of velocity is with respect to time proportions to the gradient of temperature with respect to trace. Its solution is obtained by the method of separating variables for scalar function. These results have been compared with well agreement with literatures. Highlight: The Principle of Minimum Energy Release (PMER) is used to prove the pulse-mode of explosion of nuclear weapon, as great Earthquake, and optimum path problems.
文摘PIT tests are usually performed when a mass distribution of High Explosive(H.E) projectile fragments is required. This paper shows the underwater detonation effects of 60 mm, M90 H.E. mortar bomb filled with Comp. B on cylindrical concrete structure(concrete pipe closed at one end-similar to a PIT test)which is 2 m high(inner height) with inner diameter of also 2 m. Thickness of both wall and bottom of a pipe is 0.35 m. Detailed characteristics of concrete which is used for manufacturing of a pipe are specified. Mortar bomb is submerged directly in to the water(no free airspace around the bomb) with the nose pointing to the bottom of a pipe. Number and mass of fragments after detonation are presented by table and photographs. Fragments of dummy fuze, through which blasting cap was protruded, are collected and reassembled to form a shape of a fuze after detonation where expanding of fuze material due to a detonation products is visualized. After underwater detonation, detonation of the same mortar bomb is performed in an empty pipe and the effects of this kind of detonation are observed. Distance at which fragments generated from submerged mortar bomb will not reach concrete pipes wall is also determined.
基金supported by the National Natural Science Foundation of China (No.41275049 and 41775042)
文摘The synoptic situation and mesoscale structure of an explosive extratropical cyclone over the Northwestern Pacific in March 2007 are investigated through weather station observations and data reanalysis. The cyclone is located beneath the poleward side of the exit of a 200 hPa jet, which is a strong divergent region aloft. At mid-level, the cyclone lies on the downstream side of a well-developed trough, where a strong ascending motion frequently occurs. Cross-section analyses with weather station data show that the cyclone has a warm and moist core. A ‘nose' of the cold front, which is characterized by a low-level protruding structure in the equivalent potential temperature field, forms when the cyclone moves offshore. This ‘nose' structure is hypothesized to have been caused by the heating effect of the Kuroshio Current. Two low-level jet streams are also identified on the western and eastern sides of the cold front. The western jet conveys cold and dry air at 800–900 hPa. The wind in the northern part is northeasterly, and the wind in the southern part is northwesterly. By contrast, the eastern jet carries warm and moist air into the cyclone system, ascending northward from 900 hPa to 600–700 hPa. The southern part is dominated by the southerly wind, and the wind in the northern part is southwesterly. The eastern and western jets significantly increase the air temperature and moisture contrast in the vicinity of the cold front. This increase could play an important role in improving the rapid cyclogenesis process.
基金Supported by the Science and Technology Program of Liaoning Province,No.2021-MS-040.
文摘BACKGROUND The carcinogenesis of stomach adenocarcinoma(STAD)involves many different molecules and multiple pathways,including the NOTCH signaling pathway.As a key factor that functions as a critical link in the NOTCH pathway,mind bomb 1(MIB1)is upregulated in various tumors and has been reported to promote cell metastasis and invasion.However,studies on the role of MIB1 in STAD are limited.Here,we evaluated the prognostic value of MIB1 in STAD and its association with immune infiltration and copy number variation.AIM To elucidate the relationship between MIB1 gene and gastric cancer(GC)and provide a new idea for the treatment of GC.METHODS We identified mutations in the MIB1 gene by searching the cBioPortal database and then analyzed their relationship with the overall survival rate and diseasefree survival rate using the Kaplan-Meier method.The Cancer Genome Atlas(TCGA)database provided transcript levels for MIB1 in STADs and normal tissues.As a method of distinguishing the STAD tissues from adjacent normal tissues,a receiver operating characteristic(ROC)curve was generated.Kaplan-Meier plotter was used to determine the effect of MIB1 expression on survival.Based on the LinkedOmics database,we were able to identify the coexpressed genes of the MIB1 gene,the top 50 positively correlated genes,and the top 50 negatively correlated genes.STRING was used to construct protein-protein interaction networks related to the MIB1 gene.An analysis of functional enrichment was carried out using the R package“Cluster Profiler”.The relationships between mRNA expression of MIB1 and immune infiltrates were assessed by Tumor IMmune Estimation Resource(TIMER)and the“GSVA package”in R.RESULTS According to the cBioPortal database,the MIB1 mutation rate in 287 patients in the TCGA dataset was approximately 6%.Kaplan-Meier survival analysis showed that patients with STAD in the mutated group had a worse prognosis than those in the unmutated group(P=0.0156).There was a significant upregulation of MIB1 expression in STAD tissues
