期刊文献+
共找到712篇文章
< 1 2 36 >
每页显示 20 50 100
Modulation of postoperative immune and inflammatory response by immune-enhancing enteral diet in gastrointestinal cancer patients 被引量:67
1
作者 Guo Hao Wu Yan Wei Zhang Zhao Han Wu Department of General Surgery.zhongshan Hospital,ShangHai Medical University.ShangHai 200032.China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第3期357-362,共6页
AIM: To evaluate if the administration of an enteral diet supplemented with glutamine, arginine and omega-3-fatty acids modulates inflammatory and immune responses after surgery. METHODS: A prospective randomized doub... AIM: To evaluate if the administration of an enteral diet supplemented with glutamine, arginine and omega-3-fatty acids modulates inflammatory and immune responses after surgery. METHODS: A prospective randomized double-blind, clinical trial was performed. Forty-eight patients with gastrointestinal cancer were randomized into two groups, one group was given an isocaloric and isonitrogenous standard diet and the other was fed with the supplemented diet with glutamine, arginine and omega-3-fatty acids. Feedings were started within 48 hours after operation, and continued until day 8. All variables were measured before operation and on postoperative day 1 and 8. Immune responses were determined by phagocytosis ability, respiratory burst of polymorphonuclear cells, total lymphocytes lymphocyte subsets, nitric oxide, cytokines concentration, and inflammatory responses by plasma levels of C-reactive protein, prostaglandin E2 level. RESULTS: Tolerance of both formula diets was excellent.There were significant differences in the immunological and inflammatory responses between the two groups. In supplemented group, phagocytosis and respiratory burst after surgery was higher and C-reactive protein level was lower (P【0.01) than in the standard group. The supplemented group had higher levels of nitric oxide, total lymphocytes, T lymphocytes, T-helper cells, and NK cells. Postoperative levels of IL-6 and TNF-alpha were lower in the supplemented group (P 【0.05). CONCLUSION: It was clearly established in this trial that early postoperative enteral feeding is safe in patients who have undergone major operations for gastrointestinal cancer. Supplementation of enteral nutrition with glutamine, arginine, and omega-3-fatty acids positively modulated postsurgical immunosuppressive and inflammatory responses. 展开更多
关键词 Enteral Nutrition Gastrointestinal Neoplasms Adult Aged ARGININE dosage Cytokines Double-blind method ENTERITIS Fatty Acids Omega-3 Female GLUTAMINE Humans Lymphocyte Count Male Middle Aged PHAGOCYTOSIS Postoperative Period Prospective Studies Respiratory Burst
下载PDF
中医药随机对照试验中盲法的应用与评价 被引量:34
2
作者 王丽琼 李青 +1 位作者 苏春香 刘建平 《中医杂志》 CSCD 北大核心 2014年第1期28-33,共6页
目的分析中医药随机对照试验(RCT)中盲法的应用现状,并对盲法的设计与报告进行评价。方法系统检索中国知网、中国科技期刊数据库、中国生物医学文献数据库、万方数据库,纳入所有中药治疗肠易激综合征和针刺治疗失眠的RCT。参考Cochrane... 目的分析中医药随机对照试验(RCT)中盲法的应用现状,并对盲法的设计与报告进行评价。方法系统检索中国知网、中国科技期刊数据库、中国生物医学文献数据库、万方数据库,纳入所有中药治疗肠易激综合征和针刺治疗失眠的RCT。参考Cochrane协作网系统评价员手册5.0.2版中关于研究入选的方法,由两名研究者根据纳入标准独立进行文献筛选,并按照资料提取表进行文献资料提取,采用SPSS17.0对资料进行统计描述。结果共获得1 041篇,包括864篇中药治疗肠易激综合征的RCT和177篇针刺治疗失眠的RCT,其中有32篇RCT使用盲法,总应用率为3.1%。中药治疗肠易激综合征的RCT中有24篇应用了盲法(应用率为2.8%);应用盲法的RCT中4篇(16.7%)报告了施盲对象,3篇(12.5%)报告了盲法实施细节。针刺治疗失眠的RCT中有8篇应用了盲法(应用率为4.5%);应用盲法的RCT中2篇(25.0%)报告了施盲对象,无一报告盲法的实施细节。结论以两个中医药治疗的代表性疾病为例,中医药RCT盲法应用率很低,且报告不够完整,导致试验设计的质量低下。 展开更多
关键词 盲法 随机对照试验 失眠 肠易激综合征
原文传递
Efficacy and safety of Xinfeng capsule in patients with rheumatoid arthritis:a multi-center parallel-group double-blind randomized controlled trial 被引量:29
3
作者 Liu Jian Wang Yuan +13 位作者 Huang Chuanbing Xu Jianhua Li Zhijun Xu Liang He Liyun Sun Yue Wang Yali Xu Shengqian Zhao Ping Mao Tongjun Tan Bin Zhu Fubing Zhang Pingheng Fang Li 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2015年第5期487-498,共12页
OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was conducted.Tot... OBJECTIVE:To evaluate the efficacy and safety of Xinfeng capsule in patients suffering rheumatoid arthritis(RA).METHODS:A multi-center parallel-group designed,double-blind,randomized,controlled trial was conducted.Totally 304 RA patients were assigned to two groups:one group was administered Xinfeng capsule(XFC) plus the placebo of leflunomide and the other given leflunomide(LEF) plus the placebo of XFC for twelve weeks.The clinical and laboratory parameters were compared at baseline and fourth,eighth,and twelfth weeks.RESULTS:After twelve-week treatment,patients in two groups all showed some trend of effectiveness when compared in terms of American Rheumatism Association(ACR) recommended 20%,50%,70%improvement criteria,but it was insignificant.The validity in ameliorate modified disease activity score(DAS28) and laboratory indexes as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor(RF) were also found no difference.The score of health assessment questionnaire(HAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS) and quality of life questionnaire with rheumatoid arthritis(RAQOL)both lower than the first week and the changes showed no difference.However,the score of SDS dropped more in XFC group than in the other.A total of 147 adverse reaction cases were reported,which shows no difference between the two groups.The most common adverse reactions were hepatic impairment,anemia,leukocytopenia,epigastric discomfort and phalacrosis.CONCLUSION:XFC demonstrated better improvement in the scores of SDS and compared with those of LEF group. 展开更多
关键词 Arthritis rheumatoid Xinfeng capsule Treatment outcome Multicenter study Double-blind method Randomized controlled trials
原文传递
高频超声对传统盲法针刀松解术治疗肩周炎定位及操作准确度的观察研究 被引量:21
4
作者 陈祢 沈红 王宝兰 《华西医学》 CAS 2018年第10期1262-1266,共5页
目的采用高频超声观察传统盲法针刀松解术在肩周炎治疗中定位及操作的准确度,探讨传统盲法针刀治疗存在的缺陷及可能的改进措施。方法选取2018年2月—4月在新疆医科大学第一附属医院和乌鲁木齐市中医医院确诊为肩周炎的患者42例,选取针... 目的采用高频超声观察传统盲法针刀松解术在肩周炎治疗中定位及操作的准确度,探讨传统盲法针刀治疗存在的缺陷及可能的改进措施。方法选取2018年2月—4月在新疆医科大学第一附属医院和乌鲁木齐市中医医院确诊为肩周炎的患者42例,选取针刀治疗肩周炎时常用的4个位点进行盲法操作,采用高频超声对进针点定位及施针操作过程进行观察。结果采用高频超声观察并确认徒手定位点及针刀操作点后发现,对42例患者使用徒手定位进针点的准确率高,可达100.0%(42/42)。在施针操作过程中,肱骨小结节点及三角肌下滑囊点进针操作准确率均较高,分别为95.2%(40/42)和100.0%(42/42)。但喙突点和肱骨结节间沟点因施针深度及方向存在偏差导致进针准确率低,分别为45.2%(19/42)和4.8%(2/42)。结论传统盲法针刀松解术是目前临床普遍使用的针刀治疗方法。采用高频超声观察发现,具备多年治疗经验的针刀医师使用盲法操作仍可能出现进针位置偏差。由于临床针刀可视化操作受时间、技术的限制很难普遍开展,因此建议在针刀操作培训中借助高频超声作为可视化教学工具,辅助进行针刀盲法操作技术的培训,可能对提高盲法针刀操作准确度有一定价值。 展开更多
关键词 盲法 针刀 肩周炎 高频超声
原文传递
一种基于DWT的彩色图像数字水印方案 被引量:10
5
作者 于帅珍 沈建国 《计算机工程与应用》 CSCD 北大核心 2007年第10期84-86,92,共4页
稳健性是图像隐藏水印最基本的要求之一,而水印的嵌入强度、嵌入位置影响水印的稳健性。提出了一种基于小波变换的彩色图像数字水印方案。利用了人眼视觉的掩蔽特性,在彩色图像的蓝色分量小波域的最低层逼近系数分块矩阵中,采用重复嵌... 稳健性是图像隐藏水印最基本的要求之一,而水印的嵌入强度、嵌入位置影响水印的稳健性。提出了一种基于小波变换的彩色图像数字水印方案。利用了人眼视觉的掩蔽特性,在彩色图像的蓝色分量小波域的最低层逼近系数分块矩阵中,采用重复嵌入技术自适应地嵌入水印,水印嵌入强度较大,而现有的基于小波变换的算法大多将水印嵌入在各个方向的中频或高频中。水印提取时采用两种方案,从而使该算法的抗剪切能力很强,且提取水印时不需要原始载体图像,而现有水印系统的提取方案是唯一的。实验结果表明该水印系统不仅较好地保持了图像的质量,对JPEG压缩、噪声污染、滤波、缩放、图像锐化、马赛克效应、剪切和联合攻击等图像操作都显示了较强的鲁棒性。 展开更多
关键词 离散小波变换 蓝色分量 盲检测 提取方案 稳健性
下载PDF
H型钢梁与矩形钢管柱端板单向螺栓连接节点初始转动刚度性能 被引量:13
6
作者 李国强 段炼 +1 位作者 陆烨 张杰华 《同济大学学报(自然科学版)》 EI CAS CSCD 北大核心 2018年第5期565-573,共9页
进行了6组平齐式、外伸式端板单向螺栓连接节点试验,并在现有研究成果的基础上,分别推导了单向螺栓抗拉刚度、受拉端板抗弯刚度、柱壁抗拉刚度、柱壁抗压刚度和受压外伸式端板抗压刚度的计算式.利用组件法推导了平齐式、外伸式连接节点... 进行了6组平齐式、外伸式端板单向螺栓连接节点试验,并在现有研究成果的基础上,分别推导了单向螺栓抗拉刚度、受拉端板抗弯刚度、柱壁抗拉刚度、柱壁抗压刚度和受压外伸式端板抗压刚度的计算式.利用组件法推导了平齐式、外伸式连接节点在弯矩作用下初始转动刚度的理论计算公式.结果表明:给出的节点初始转动刚度的计算式与试验结果吻合较好,精度可满足工程设计的要求.最后,提出了H型钢梁与矩形钢管(RHS)柱端板单向螺栓连接节点的设计建议. 展开更多
关键词 单向螺栓 矩形钢管(RHS)柱 梁柱连接节点 组件法 初始转动刚度
下载PDF
Effectiveness of Jinying capsule on pelvic inflammatory disease in patients with symptom pattern of damp and heat accumulation: a double-blinded, multicenter, randomized, placebo-controlled clinical trial 被引量:11
7
作者 Yang Yan Lu Yao +7 位作者 Zhou Deping Pei Fenglan Li Qin Chen Shuqiong Wang Qiufeng Wang Yanting Jin Zhe Liu Yanxia 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2020年第3期432-439,共8页
OBJECTIVE: To evaluate the therapeutic effectiveness and safety of Jinying capsule on pelvic inflammatory disease(PID) in patients with symptoms identified as the pattern of damp and heat accumulation in terms of Trad... OBJECTIVE: To evaluate the therapeutic effectiveness and safety of Jinying capsule on pelvic inflammatory disease(PID) in patients with symptoms identified as the pattern of damp and heat accumulation in terms of Traditional Chinese Medicine(TCM).METHODS: We conducted a double-blinded, multicenter, randomized, placebo-controlled clinical trial which included 155 patients diagnosed with PID and identified as symptom pattern of damp and heat accumulation. They were randomly divided into experimental group(n = 78) and control group(n = 77) according to a random number table. The treatment lasted for a period of 28 d. The experimental group was given Jinying capsules and oral levofloxacin plus oral metronidazole for first 7 d.They continued with Jinying capsules and levofloxacin placebo and metronidazole placebo for another 7 d. For the remaining 14 d, they continued with Jinying capsules only. Whereas, the control group was treated with oral levofloxacin and metronidazole and Jinying capsule placebo for the first 14 d in the same way as the experimental group and then continued with Jinying capsule placebo only for the remaining 14 d. The clinical efficacy was assessed using McCormack scale, TCM symptom pattern scores, physicochemical indexes including white blood cell and erythrocyte sedimentation rate, C-reaction protein, smear of vaginal discharge,and pelvic ultrasound.RESULTS: Comparing McCormack scale between both groups after treatment, the difference in curative effect between both groups was significant (P = 0.0269). The cure rate of the experimental group and control group is 76.32% and 59.46% respectively at week 4. Comparing TCM symptom pattern scores between both groups before and after treatment, the differences in total effective rate were both significant(P < 0.05). The curative effect rate of experimental group is 2.63% and 13.70% of the control group at week 1(P = 0.0131), and73.33% of the experimental group and 56.94% of the control group at week 4(P = 0.0369). No significant differences were found 展开更多
关键词 Pelvic inflammatory disease Dampness-heat Therapeutic uses Safety Randomized controlled trial Double-blind method Jinying capsule
原文传递
OFDM系统中同步算法的分析与比较 被引量:6
8
作者 罗仁泽 《电讯技术》 2006年第4期150-155,共6页
对近年来具有代表性的53种同步算法进行了分析和比较,指出了各自的优缺点,提出了下一步研究的方向。这对于无线通信OFDM系统中同步技术研究具有重要指导意义。
关键词 OFDM系统 同步 PN序列 盲方法
下载PDF
瞬变电磁消除勘探盲区的技术方法及应用效果 被引量:9
9
作者 李建新 涂勇刚 《工程地球物理学报》 2014年第3期361-365,共5页
瞬变电磁(TEM)测深由于采样率(关断延时)的限制导致第一个数据采样的时间往往在数十微秒后进行,而不能在0时刻进行采样,就是人们所说的数据勘探盲区,根据地层浅部电阻率大小,这种勘探盲区高达数十米甚至上百米,随着地层电阻率的增大而增... 瞬变电磁(TEM)测深由于采样率(关断延时)的限制导致第一个数据采样的时间往往在数十微秒后进行,而不能在0时刻进行采样,就是人们所说的数据勘探盲区,根据地层浅部电阻率大小,这种勘探盲区高达数十米甚至上百米,随着地层电阻率的增大而增大,严重制约TEM资料对地层浅部的分析、反演及解释,尤其对于目标体深度小于第一个采样深度的情况甚至会产生错误的结果;利用美国Zonge公司开发的GDP32Ⅱ的NanoTEM系统(纳米瞬变电磁系统)可以进行快速关断和快速取样方案使得首次采样率最小可以到达1.2μs,将常规TEM方法和NanoTEM方法有机结合起来,可以大大消除TEM方法的勘探盲区,提高资料解释的精度,通过生产实践摸索一套二者结合的方式、方法及参数,取得了很好的效果。 展开更多
关键词 瞬变电磁 纳米瞬变电磁 勘探盲区 消除方法 实践效果
下载PDF
基于改进未确知测度法的光伏发电项目应急能力成熟度评估模型研究 被引量:8
10
作者 李丹阳 赵云胜 +2 位作者 史小棒 张超 章志超 《工程管理学报》 2017年第5期117-122,共6页
为实现对光伏发电项目应急能力的系统分析和科学评估,基于未确知数学原理,结合施工作业特点,构建光伏发电项目应急能力成熟度评估模型。利用成熟度理论划分光伏发电项目应急能力成熟度等级,并建立评估指标体系;应用盲数和未确知测度理... 为实现对光伏发电项目应急能力的系统分析和科学评估,基于未确知数学原理,结合施工作业特点,构建光伏发电项目应急能力成熟度评估模型。利用成熟度理论划分光伏发电项目应急能力成熟度等级,并建立评估指标体系;应用盲数和未确知测度理论改进未确知测度模型,融合熵权法建立量化的应急能力成熟度等级测度方法。结合某光伏发电项目评估其应急能力成熟度,结果表明改进方法适用性强、便于操作、贴近实际情况;利用评估指标成熟度雷达模型图,直观找出应急管理过程中的薄弱环节,实现应急精细化管理。 展开更多
关键词 光伏发电项目 应急能力 成熟度模型 未确知测度 盲数 熵权法
下载PDF
Endosonography with linear array instead of endoscopic retrograde cholangiography as the diagnostic tool in patients with moderate suspicion of common bile duct stones 被引量:7
11
作者 Maciej Kohut Andrzej Nowak +2 位作者 Ewa Nowakowska-Dufawa Tomasz Marek Roman Kaczor 《World Journal of Gastroenterology》 SCIE CAS CSCD 2003年第3期612-614,共3页
AIM: To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS).METHODS: 55 patients with moderate clinical ... AIM: To evaluate the diagnostic efficiency of endoscopic ultrasound (EUS) as the main imaging modality in patients with moderate suspicion of common bile duct stones (CBDS).METHODS: 55 patients with moderate clinical suspicion of CBDS were prospectively included to the study and evaluated with EUS. This study was done in single blind method in the clinical and biochemical data of patients. EUS was done with echo-endoscope Pentax FG 32-UA (f=5-7,5 MHz) and Hitachi EUB 405 ultrasound machine. Patients diagnosed with CBDS by EUS were excluded from this study and treated with ERC. All the other patients were included to the follow up study obtained by mail every 6 months for clinical evaluation (need of ERC or surgery).RESULTS: CBDS was found in 4 patients by EUS. Diagnosis was confirmed in all cases on ERC. The remaining 51 patients without CBDS on EUS were followed up for 6-26 months (meanly 13 months) There were: 40 women, 42cholecystectomized patients, aged: 55 (mean). Biochemical values (mean values) were as follows: bilirubin: 14,9 μmol.L-1,alkaline phosphatase: 95 IU.L-,1 γ-GTP: 131 IU.L-1, ALT: 50IU.L-1, AST: 49 IU.L-1, Only 1 patient was lost for follow up.In the remaining 50 patients with follow up, there was only 1 (2 %) patient with persistent biliary symptoms in whom CBDS was finally diagnosed by ERC with ES. All other patients remained symptoms free on follow up and did not require ERC or biliary surgery.CONCLUSION: Vast majority of patients with moderate suspicion of CBDS and no stones on EUS with linear array can avoid invasive evaluation of biliary tree with ERC. 展开更多
关键词 Aged CHOLANGIOGRAPHY Endoscopy ENDOSONOGRAPHY Female GALLSTONES Humans Male Middle Aged Prospective Studies Single-blind method
下载PDF
Efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and gallbladder:a randomized,double-blind,controlled trial 被引量:8
12
作者 Ye Qing Zhou Jie +2 位作者 Yuan Xiaolei Yuan Canxing Yang Xuming 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2015年第4期381-388,共8页
OBJECTIVE: To evaluate the clinical efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and gallbladder.METHODS: We conducted a double-blind,randomized,controlled trial involving 100... OBJECTIVE: To evaluate the clinical efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and gallbladder.METHODS: We conducted a double-blind,randomized,controlled trial involving 100 patients with insomnia of Qi-deficiency of heart and gallbladder.Patients were randomly divided into the treatment group(n = 50) and the control group(n = 50) according to a random number table. The treatment group was given Zhenjingdingzhi decoction,while the control group was treated with Suanzaoren decoction. the pharmacological treatment lasted for 8weeks. The clinical efficacy was assessed by using Spiegel scale,Pittsburgh sleep quality index(PSQI)and Traditional Chinese Medicine(TCM) syndrome scores.RESULTS: Comparing Spiegel scores between the two groups at 4 and 8 weeks,the differences in curative effect between the two groups were both significant(both P < 0.05). The total effective rate was46% in the treatment group and 27.7% in the control group at 4 weeks,and 80% and 53.2% at 8weeks,respectively; After 8 weeks,PSQI scores showed that the total effective rates differed significantly between the two groups(P < 0.01): 84% in the treatment group and 59.6% in the control group; In improving sleep quality and sleep duration,the curative effect of the treatment group was better than that of the control group(P < 0.05).TCM syndrome,especially insomnia and palpitation,was improved better in the treatment group after 8 weeks as compared to that in the control group(P < 0.05). The total effective rate of the two groups was 84% and 66%,respectively.CONCLUSION: Zhenjingdingzhi decoction is effective and safe for the treatment of insomnia with Qi-deficiency of heart and gallbladder,especially for improving sleep quality and sleep duration. 展开更多
关键词 Sleep initiation and maintenance disorders Shyness Heart Qi deficiency Zhenjingdingzhi decoction Randomized controlled trial Double-blind method
原文传递
Elastic针具:一套一体式可弹缩双盲安慰针 被引量:1
13
作者 刘静怡 白鹏 《中国针灸》 CAS CSCD 北大核心 2024年第2期221-223,共3页
研制一套应用于针刺随机对照试验的临床用具——Elastic (有弹性的)针具,使双盲安慰对照成为可能。此针具包括外观完全一致的真针与假针(安慰针),两者均由一体式帽型针柄与针体构成,针柄底端设有用于固定的无菌双面胶垫,安慰针内置有微... 研制一套应用于针刺随机对照试验的临床用具——Elastic (有弹性的)针具,使双盲安慰对照成为可能。此针具包括外观完全一致的真针与假针(安慰针),两者均由一体式帽型针柄与针体构成,针柄底端设有用于固定的无菌双面胶垫,安慰针内置有微型低线径弹簧。施术时,真针正常刺入皮肤,安慰针的弹簧可在针施压于皮肤时产生弹力而回缩,皮肤与弹簧之间的力差达到一定平衡后即产生得气感;该针具的胶垫设计可模拟进针时所产生的阻滞感,从外观和感觉上保证双盲的实施。 展开更多
关键词 安慰针 假针 真针 双盲 盲法
原文传递
盲法质量评价方法在中医临床试验中的应用 被引量:1
14
作者 施泽阳 孙源 +6 位作者 马文欣 王禹毅 卜志军 王雪惠 郑酉友 刘建平 刘兆兰 《中国实验方剂学杂志》 CAS CSCD 北大核心 2024年第3期75-80,共6页
盲法质量评价是对实施盲法的临床试验所获得的临床盲化数据进行评估,通过调查分析不同设盲对象的致盲效果来判断盲法实施的有效性。成功的盲法能够在一定程度上避免受试对象和研究者由于主观因素对试验结果造成的影响,而通过盲法质量评... 盲法质量评价是对实施盲法的临床试验所获得的临床盲化数据进行评估,通过调查分析不同设盲对象的致盲效果来判断盲法实施的有效性。成功的盲法能够在一定程度上避免受试对象和研究者由于主观因素对试验结果造成的影响,而通过盲法质量评价不仅可以反映盲法实施的有效性,更能体现临床试验结果的准确性和可信度。近年来随机对照试验广泛应用于中医药临床疗效评价,但其盲法的实施质量参差不齐,尚未形成评价标准。该文对两种定量盲法质量评价方法——James盲法指数(JBI)和Bang盲法指数(BBI)的数据收集方式、计算原理和优缺点进行介绍,并在一项针灸缓解口腔术后疼痛的随机对照试验中进行2种指数的实例分析,应用R软件演示结果计算过程并通过森林图进行可视化展示,同时设计了便于在试验不同阶段进行中医药临床试验盲法评价资料收集的工具表,最后对盲法质量评价在中医药研究中的必要性和可行性进行探讨,以期为评价和提高中医药临床试验中盲法实施质量提供依据。 展开更多
关键词 盲法 质量评价 临床试验 中医 方法学
原文传递
热敏灸预处理对原发性痛经患者临床疗效及子宫动脉血流的影响——一项随机对照盲法试验 被引量:3
15
作者 李自如 康明非 +2 位作者 郑琼 杨瑞 迟振海 《中医杂志》 CSCD 北大核心 2023年第18期1903-1907,共5页
目的比较热敏灸在经期前介入与月经当天介入治疗原发性痛经的临床疗效差异,以优化临床治疗方案。方法将纳入的60例原发性痛经患者随机分为预处理组和常规处理组,每组30例。所有患者仰卧位时选取双侧子宫穴与归来穴合围的区域,俯卧位时... 目的比较热敏灸在经期前介入与月经当天介入治疗原发性痛经的临床疗效差异,以优化临床治疗方案。方法将纳入的60例原发性痛经患者随机分为预处理组和常规处理组,每组30例。所有患者仰卧位时选取双侧子宫穴与归来穴合围的区域,俯卧位时选择双侧肾俞穴与次髎穴合围的区域,分别施回旋灸2 min,雀啄灸1 min,再循经往返灸激发灸感,找出所有热敏穴,最终选择2个灸感最好的热敏穴进行治疗。预处理组于月经来临前3~7天开始施灸,常规处理组于月经当天施灸,两组均每日1次,每个月经周期治疗7天,连续进行3个月经周期。治疗前后进行COX痛经症状评价量表(CMSS)评分、疼痛视觉模拟量表(VAS)评分,检测子宫动脉血流动力学指标[包括血液搏动指数(PI)和阻力指数(RI)],治疗后比较两组患者的中医临床疗效。结果两组治疗后CMSS评分、VAS评分、PI、RI均低于本组治疗前,且治疗后预处理组VAS评分、CMSS评分、PI、RI低于常规处理组(P<0.05或P<0.01)。预处理组治疗后中医临床疗效总有效率为93.3%(28/30),优于常规处理组的73.3%(22/30,P<0.05)。结论热敏灸在经期前介入治疗原发性痛经的临床疗效优于月经当天介入治疗,能更好地改善患者痛经症状和子宫局部血液循环。 展开更多
关键词 原发性痛经 热敏灸 逆针灸 子宫动脉血流 随机对照试验 盲法
原文传递
基于盲数理论的最优化方法与程序实现 被引量:5
16
作者 石博强 赵德祥 +1 位作者 李海鹏 肖成勇 《北京科技大学学报》 EI CAS CSCD 北大核心 2007年第5期523-527,共5页
使用盲数表达优化设计中的不确定变量,结合常用的基于实数变量的优化算法,提出了基于盲数的优化方法.该方法从微观的角度分析和描述设计变量与优化参数之间的关系,给出优化问题的盲数解.盲数解不但给出了设计变量的取值,而且还给出了不... 使用盲数表达优化设计中的不确定变量,结合常用的基于实数变量的优化算法,提出了基于盲数的优化方法.该方法从微观的角度分析和描述设计变量与优化参数之间的关系,给出优化问题的盲数解.盲数解不但给出了设计变量的取值,而且还给出了不同取值时优化对象处于最优状态的可靠性的评价. 展开更多
关键词 机械优化设计 优化方法 盲数 不确定性 程序 半轴
下载PDF
重氮试验在盲插鼻肠管时末端位置判断中的应用效果研究
17
作者 宋淳 温坤 +4 位作者 张鲁 仲秀玲 李燕 李丽 王晓云 《军事护理》 CSCD 北大核心 2024年第9期42-45,共4页
目的探讨重氮试验在盲插鼻肠管后末端位置判断的应用效果。方法采用便利抽样法,选取2021年9月至2022年1月山东省某三级甲等医院重症监护病房(intensive care unit,ICU)进行盲插鼻肠管术的216名患者为研究对象。采用重氮试验、测pH值、... 目的探讨重氮试验在盲插鼻肠管后末端位置判断的应用效果。方法采用便利抽样法,选取2021年9月至2022年1月山东省某三级甲等医院重症监护病房(intensive care unit,ICU)进行盲插鼻肠管术的216名患者为研究对象。采用重氮试验、测pH值、观察回抽液性质三种方式预测鼻肠管末端位置,以X线摄片为判定的金标准,确认鼻肠管末端位置。比较重氮试验及其他两种方式预测的准确率、敏感度、特异度、阳性结果预测值(positive predictive value,PPV)、阴性结果预测值(negative predictive value,NPV)、阳性似然比(positive likelihood ratio,PLR)、阴性似然比(negative likelihood ratio,NLR)等指标。结果pH值判断的敏感度为97.7%、NPV为84.0%、NLR为0.045;回抽液性质判断的特异度为82.9%、PPV为95.5%、PLR为4.912;重氮试验方式的准确率为92.6%、Kappa系数为0.755;受试者操作特征曲线下面积最大为0.870,95%CI(0.793,0.947)。结论重氮试验判断盲插鼻肠管末端位置的准确率、一致性较好,具有较高的临床预测价值。 展开更多
关键词 鼻肠管 盲插法 重氮试验 管道位置 判断方式
下载PDF
测氡法在低射气区隐伏断层探测的应用 被引量:6
18
作者 刘波 张新军 王兴 《煤矿安全》 CAS 北大核心 2015年第5期156-159,共4页
隐伏断层的勘探是各种工程施工的一项重要任务。在分析隐伏断层地表氡值形成规律的基础上,结合研究区测氡法观测数据的分形分析和异常解释,划分氡值异常范围,并解释地下断层信息。研究发现:分形方法相对于统计学方法可以合理地划分异常... 隐伏断层的勘探是各种工程施工的一项重要任务。在分析隐伏断层地表氡值形成规律的基础上,结合研究区测氡法观测数据的分形分析和异常解释,划分氡值异常范围,并解释地下断层信息。研究发现:分形方法相对于统计学方法可以合理地划分异常范围;通过地表氡值的峰形可以初步判断地下隐伏断层的倾向。 展开更多
关键词 测氡法 地质勘探 隐伏断层 分形方法 倾向
原文传递
Effect of acupuncture anesthesia on acne vulgaris of pricking-blood-letting cupping: a single-blind randomized clinical trail 被引量:6
19
作者 Jianfeng Xu Ruizhu Lin +5 位作者 Jing Wang Yongli Wu Yingxu Wang Yuequan Zhang Chaolei Xi Qiang Wu 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2013年第6期752-756,共5页
OBJECTIVE: To evaluate the effect on acne vulgaris of pricking-bloodletting cupping at Dazhui(GV 14) under acupuncture anesthesia, and establish whether providing anesthesia to the treatment area by manipulating Hegu(... OBJECTIVE: To evaluate the effect on acne vulgaris of pricking-bloodletting cupping at Dazhui(GV 14) under acupuncture anesthesia, and establish whether providing anesthesia to the treatment area by manipulating Hegu(LI 4) and Quchi(LI 11) might have an additional therapeutic benefit. METHODS: Thirty-eight patients were recruited and randomized into a control group and an intervention group with a single-blind(observer-blind) method. The control group was treated by pricking-bloodletting cupping at Dazhui(GV 14) and the studied group by pricking-bloodletting cupping at Dazhui(GV 14) under acupuncture anesthesia at Hegu(LI 4) and Quchi(LI 11). Both groups were treated twice weekly for 6 weeks. The analgesic and therapeutic effects of acupuncture were evaluated on a visual analog scale(VAS) and global acne grading system(GAGS), respectively.RESULTS: There were differences in the VAS scores of pain on pricking and in the pricked area, and the duration of pain between the groups. After 12 treatments, there was a significant reduction in GAGS scores from baseline in both groups, but there was no significant difference between the groups. CONCLUSION: Acupuncture anesthesia at Hegu(LI 4) and Quchi(LI 11) is an effective means of alleviating the pain of pricking-bloodletting cupping and reducing the duration of pain in the treatment area. Pricking-bloodletting cupping at Dazhui(GV 14) improves the skin lesions of patients with moderate acne vulgaris, but acupuncture anesthesia does not appear to have an additional therapeutic effect. 展开更多
关键词 Acupuncture anesthesia Bloodlettingtherapy Acne vulgaris Single-blind method Ran-domized controlled trial Point Dazhui (GV 14) Point Hegu (LI 4) Point Quchi (LI 11
原文传递
基于卡尔曼滤波的极限学习机在线盲均衡算法 被引量:6
20
作者 杨凌 程丽 +1 位作者 韩琴 赵傲男 《系统工程与电子技术》 EI CSCD 北大核心 2021年第3期623-630,共8页
针对正交振幅调制(quadrature amplitude modulation,QAM)信号,在预测方法的盲均衡框架下,基于卡尔曼滤波(Kalman filter,KF)提出了一种新的神经网络在线盲均衡算法。采用复数型极限学习机(complex extreme learning machine,C-ELM)作... 针对正交振幅调制(quadrature amplitude modulation,QAM)信号,在预测方法的盲均衡框架下,基于卡尔曼滤波(Kalman filter,KF)提出了一种新的神经网络在线盲均衡算法。采用复数型极限学习机(complex extreme learning machine,C-ELM)作为非线性预测滤波器(prediction filter,PF),用KF实时更新C-ELM的输出权值以使预测误差达到最小,再通过自动增益装置调整信号的幅度变化,最后引入相位调整因子纠正信号的相位旋转。仿真结果表明,所提算法实现了良好的实时均衡效果,具有较快的收敛速率和较小的稳态均方误差,不仅适用于方形,同时也适用于十字形QAM信号的盲均衡。 展开更多
关键词 盲均衡 预测方法 复数型极限学习机 卡尔曼滤波
下载PDF
上一页 1 2 36 下一页 到第
使用帮助 返回顶部