Study of interfacial processes between incorporated biomolecules and hydrogel matrix is of primary importance for the application of synthetic hydrogels as biomaterials, sensors, etc. Their hydrophilic nature, however...Study of interfacial processes between incorporated biomolecules and hydrogel matrix is of primary importance for the application of synthetic hydrogels as biomaterials, sensors, etc. Their hydrophilic nature, however, hampers fat-soluble biomolecule incorporation. We synthesized N-isopropylacrylamide (NIPAAm)- and Acrylamide (AA)-based hydrogels with hydrophilic-lipophilic balance that under specific conditions permit homogeneous incorporation of provitamins D3(7-dehydrocholesterol) and D2(ergosterol) dissolved in ethanol. Similarity of provitamins D photoisomerization in such hydrogel matrices with the photoreaction in ethanol shows great potential of the novel material for personal dosimetry of biologically active ‘antirachitic’ UV radiation.展开更多
Ionizing radiation can cause radiation injury to the human body under certain circumstances,such as unexpected radiation accidents and nuclear terrorist attacks.Methods that can accurately and rapidly measure the biol...Ionizing radiation can cause radiation injury to the human body under certain circumstances,such as unexpected radiation accidents and nuclear terrorist attacks.Methods that can accurately and rapidly measure the biological effects are necessary for rational triage and treatment of affected patients.In recent decades,significant researches attention has been focused on the development of accurate and efficient biodosimeters.In this review,we summarize recent developments in biological dosimeters,with a primary focus on cell-based and molecular markers,including comet assay,dicentric chromosome aberration,γ-H2AX,micronuclei,microRNA,lncRNA,and 8-Oxo-dG.展开更多
文摘Study of interfacial processes between incorporated biomolecules and hydrogel matrix is of primary importance for the application of synthetic hydrogels as biomaterials, sensors, etc. Their hydrophilic nature, however, hampers fat-soluble biomolecule incorporation. We synthesized N-isopropylacrylamide (NIPAAm)- and Acrylamide (AA)-based hydrogels with hydrophilic-lipophilic balance that under specific conditions permit homogeneous incorporation of provitamins D3(7-dehydrocholesterol) and D2(ergosterol) dissolved in ethanol. Similarity of provitamins D photoisomerization in such hydrogel matrices with the photoreaction in ethanol shows great potential of the novel material for personal dosimetry of biologically active ‘antirachitic’ UV radiation.
基金This review was funded by Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2017-1001-08)National Natural Science Foundation of China(81772243,31971168,81803172).
文摘Ionizing radiation can cause radiation injury to the human body under certain circumstances,such as unexpected radiation accidents and nuclear terrorist attacks.Methods that can accurately and rapidly measure the biological effects are necessary for rational triage and treatment of affected patients.In recent decades,significant researches attention has been focused on the development of accurate and efficient biodosimeters.In this review,we summarize recent developments in biological dosimeters,with a primary focus on cell-based and molecular markers,including comet assay,dicentric chromosome aberration,γ-H2AX,micronuclei,microRNA,lncRNA,and 8-Oxo-dG.
