There is an increasing interest in the development of magnesium alloys both for industrial and biomedical applications. Industrial interest in magnesium alloys is based on strong demand of weight reduction of transpor...There is an increasing interest in the development of magnesium alloys both for industrial and biomedical applications. Industrial interest in magnesium alloys is based on strong demand of weight reduction of transportation vehicles for better fuel efficiency, so higher strength, and better ductility and corrosion resistance are required. Nevertheless, biomedical magnesium alloys require appropriate mechanical properties, suitable degradation rate in physiological environment, and what is most important, biosafety to human body. Rather than simply apply commercial magnesium alloys to biomedical field, new alloys should be designed from the point of view of nutriology and toxicology. This article provides a review of state-of-the-art of magnesium alloy implants and devices for orthopedic, cardiovascular and tissue engineering applications. Advances in new alloy design, novel structure design and surface modification are overviewed. The factors that influence the corrosion behavior of magnesium alloys are discussed and the strategy in the future development of biomedical magnesium alloys is proposed.展开更多
基金supported by the National Basic Research Program of China(973 Program)(Nos.2012CB619102 and 2012CB619100)the National Science Fund for Distinguished Young Scholars(No.51225101)+4 种基金the National Natural Science Foundation of China(No.31170909)the Research Fund for the Doctoral Program of Higher Education(No.20100001110011) the Natural Science Foundation of Heilongjiang Province(No. ZD201012)the Project for Supervisor of Excellent Doctoral Dissertation of Beijing(No.20121000101)the Guangdong Province Innovation R&D Team Project(No.201001 C0104669453)
文摘There is an increasing interest in the development of magnesium alloys both for industrial and biomedical applications. Industrial interest in magnesium alloys is based on strong demand of weight reduction of transportation vehicles for better fuel efficiency, so higher strength, and better ductility and corrosion resistance are required. Nevertheless, biomedical magnesium alloys require appropriate mechanical properties, suitable degradation rate in physiological environment, and what is most important, biosafety to human body. Rather than simply apply commercial magnesium alloys to biomedical field, new alloys should be designed from the point of view of nutriology and toxicology. This article provides a review of state-of-the-art of magnesium alloy implants and devices for orthopedic, cardiovascular and tissue engineering applications. Advances in new alloy design, novel structure design and surface modification are overviewed. The factors that influence the corrosion behavior of magnesium alloys are discussed and the strategy in the future development of biomedical magnesium alloys is proposed.
