AIM:To evaluate the adequacy of surgical treatment of T2 gallbladder carcinoma(GBCa)according to tumor spread in the subserosal layer. METHODS:A series of 84 patients with GBCa were treated at Saga University Hospital...AIM:To evaluate the adequacy of surgical treatment of T2 gallbladder carcinoma(GBCa)according to tumor spread in the subserosal layer. METHODS:A series of 84 patients with GBCa were treated at Saga University Hospital,Japan between April 1989 and October 2008.The tumor stage was graded according to the TNM staging for GBCa from the American Joint Committee on Cancer Manual 6th edition. Tumor staging revealed 30 patients with T2 tumors.T2 GBCa was divided into three groups histologically by the extent of tumor spread in the subserosal layer,using a score of ss minimum(ss min),ss medium(ss med)or ss massive(ss mas). RESULTS:For ss min GBCa,there was no positive pathological factor and patient survival was satisfactory with simple cholecystectomy,with or without extra-he- patic bile duct resection.For ss med GBCa,some pathological factors,h-inf(hepatic infiltration),ly(lymphatic invasion)and n(lymph node metastasis),were positive. For ss mas GBCa,there was a high incidence of positive pathological factors.The patient group with extra-hepatic bile duct resection with D2 lymph node dissection (BDR with D2)and those with S4a5 hepatectomy had significantly better survival rates.CONCLUSION:We suggest that radical surgery is not necessary for ss min GBCa,and partial hepatectomy and BDR are necessary for both ss med and ss mas GBCa.展开更多
BACKGROUND: Bilio-intestinal drainage is routinely per- formed by Roux-en-Y reconstruction after resection of the central bile duct. Alternatively reconstruction can be achieved by cholangio-duodenal interposition of ...BACKGROUND: Bilio-intestinal drainage is routinely per- formed by Roux-en-Y reconstruction after resection of the central bile duct. Alternatively reconstruction can be achieved by cholangio-duodenal interposition of an isolated jejunal segment (CDJI). This method offers the benefit of potential endoscopic control and intervention during fol- low-up. Critics of CDJI assume a higher rate of postopera- tive cholangitis compared to the Roux-en-Y construction. METHODS: Seventy-six patients with malignant tumors (n = 56) or benign strictures and choledochal cysts (n =20) were treated between 1989 and 2002 by cholangio-duodenal interposition of an isolated jejunal segment (measuring 15- 25 cm) after central bile duct resection. In 22 patients endoscopic control was first performed postoperatively dur- ing hospitalization. In 12 patients bilio-intestinal anastomo- sis could be inspected endoscopically. In the remaining patients the anastomosis could not be visualized endoscopi- cally because of kinking of the jejunal segment, but in all patients it could be evaluated by endoscopic retrograde cholangiography (ERC). RESULTS: During follow-up, 25 (33%) patients died from extrahepatic tumor recurrence. Three patients receiving CDJI after severe iatrogenic bile duct injury developed anas- tomotic strictures. Two of these patients were treated by endoscopic pigtail drainage, and one was treated by percu- taneous drainage. Two patients who had received CDJI af- ter choledochal cyst resection developed cholestasis post- operatively because of sludge formation (1 patient) and an intrahepatic concrement (1), which could be solved endo- scopically. One patient after resection of a Klatskin tumor developed an anastomotic stricture which could not be vi- sualized endoscopically, making percutaneous drainage necessary. The rate of postoperative cholangitis after CDJI in our patients was comparable to that after the Roux-en-Y reconstruction.CONCLUSION: Interposition of an isolated jejunal seg- ment for reconstruction after bile duct r展开更多
文摘AIM:To evaluate the adequacy of surgical treatment of T2 gallbladder carcinoma(GBCa)according to tumor spread in the subserosal layer. METHODS:A series of 84 patients with GBCa were treated at Saga University Hospital,Japan between April 1989 and October 2008.The tumor stage was graded according to the TNM staging for GBCa from the American Joint Committee on Cancer Manual 6th edition. Tumor staging revealed 30 patients with T2 tumors.T2 GBCa was divided into three groups histologically by the extent of tumor spread in the subserosal layer,using a score of ss minimum(ss min),ss medium(ss med)or ss massive(ss mas). RESULTS:For ss min GBCa,there was no positive pathological factor and patient survival was satisfactory with simple cholecystectomy,with or without extra-he- patic bile duct resection.For ss med GBCa,some pathological factors,h-inf(hepatic infiltration),ly(lymphatic invasion)and n(lymph node metastasis),were positive. For ss mas GBCa,there was a high incidence of positive pathological factors.The patient group with extra-hepatic bile duct resection with D2 lymph node dissection (BDR with D2)and those with S4a5 hepatectomy had significantly better survival rates.CONCLUSION:We suggest that radical surgery is not necessary for ss min GBCa,and partial hepatectomy and BDR are necessary for both ss med and ss mas GBCa.
文摘BACKGROUND: Bilio-intestinal drainage is routinely per- formed by Roux-en-Y reconstruction after resection of the central bile duct. Alternatively reconstruction can be achieved by cholangio-duodenal interposition of an isolated jejunal segment (CDJI). This method offers the benefit of potential endoscopic control and intervention during fol- low-up. Critics of CDJI assume a higher rate of postopera- tive cholangitis compared to the Roux-en-Y construction. METHODS: Seventy-six patients with malignant tumors (n = 56) or benign strictures and choledochal cysts (n =20) were treated between 1989 and 2002 by cholangio-duodenal interposition of an isolated jejunal segment (measuring 15- 25 cm) after central bile duct resection. In 22 patients endoscopic control was first performed postoperatively dur- ing hospitalization. In 12 patients bilio-intestinal anastomo- sis could be inspected endoscopically. In the remaining patients the anastomosis could not be visualized endoscopi- cally because of kinking of the jejunal segment, but in all patients it could be evaluated by endoscopic retrograde cholangiography (ERC). RESULTS: During follow-up, 25 (33%) patients died from extrahepatic tumor recurrence. Three patients receiving CDJI after severe iatrogenic bile duct injury developed anas- tomotic strictures. Two of these patients were treated by endoscopic pigtail drainage, and one was treated by percu- taneous drainage. Two patients who had received CDJI af- ter choledochal cyst resection developed cholestasis post- operatively because of sludge formation (1 patient) and an intrahepatic concrement (1), which could be solved endo- scopically. One patient after resection of a Klatskin tumor developed an anastomotic stricture which could not be vi- sualized endoscopically, making percutaneous drainage necessary. The rate of postoperative cholangitis after CDJI in our patients was comparable to that after the Roux-en-Y reconstruction.CONCLUSION: Interposition of an isolated jejunal seg- ment for reconstruction after bile duct r
