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Extracts of the seaweed Bifurcaria bifurcata display antifungal activity against human dermatophyte fungi 被引量:1
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作者 CARVALHO G.Loic SILVA Raquel +2 位作者 GONCALVES J.Maria BATISTA T.Maria PEREIRA Leonel 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2019年第3期848-854,共7页
Bifurcaria bifurcata is a seaweed of the Order Fucales(Ochrophyta,Phaeophyceae)that can be found all year round along the Portuguese Atlantic shore.Although it is considered edible in some countries,its biotechnologic... Bifurcaria bifurcata is a seaweed of the Order Fucales(Ochrophyta,Phaeophyceae)that can be found all year round along the Portuguese Atlantic shore.Although it is considered edible in some countries,its biotechnological potential has not yet been assessed in detail and here we report its antimicrobial potential against human dermatophyte fungi.Three samples were harvested from Baleal Island(Peniche,Portugal)harvested in winter(BbPe);from Aguda Beach(Arcozelo,Vila Nova de Gaia,Portugal),harvested in autumn(BbAg)and a sample obtained by culturing the Aguda sample under laboratory conditions(BbLC).A broth macrodilution assay was applied to determine the MIC(minimum inhibitory concentration)and MLC(minimum lethal concentration)of the B.bifurcata extracts.Results show that the BbPe MeOH extracts were the most effective and had higher antifungal activity against all the tested dermatophyte strains than the BbLC and BaAg extracts[Epidermophyton floccosum FF9(100–200μg/mL MIC;200μg/mL MLC),Microsporum canis FF1(400μg/mL MIC;≥400μg/mL MLC),Trichophyton mentagrophytes FF7(100μg/mL MIC;>800μg/mL MLC),M.gypseum CECT 2908(800μg/mL MIC;≥800μg/mL MLC),T.mentagrophytes var.interdigitale CECT 2958(800μg/mL MIC;≥800μg/mL MLC),T.rubrum CECT 2794(200μg/mL MIC;≥400μg/mL MLC)].In fact,only E.floccosum FF9 was sensitive to BbAg and BbLC MeOH extracts.To our knowledge,this is the first report of antifungal activity of B.bifurcata against human dermatophyte fungi. 展开更多
关键词 SEAWEED bifurcaria bifurcata bioactivity ANTIFUNGAL DERMATOPHYTES minimum inhibitory concentration minimum lethal concentration
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