Direct chemoselective oxidation of δ-lactones via highly stable benzyl radical cyclization is reported. The one-pot conversion of premade substituted 5-aryl pentanoic acid and 8-benzyl-1-naphthoic acid in the presenc...Direct chemoselective oxidation of δ-lactones via highly stable benzyl radical cyclization is reported. The one-pot conversion of premade substituted 5-aryl pentanoic acid and 8-benzyl-1-naphthoic acid in the presence of K2S2Os--CuCl2 results to the δ-lactones in moderate to good yields. The advantages of this methodology is using water as a solvent and utilizing available starting materials.展开更多
Studies on the mechanism of the reactions involving coenzyme NAD(P)H and its model compounds are of considerable significance for understanding the role and the mechanism of this coenzyme in living cells. Although the...Studies on the mechanism of the reactions involving coenzyme NAD(P)H and its model compounds are of considerable significance for understanding the role and the mechanism of this coenzyme in living cells. Although there have been extensive studies on the mechanism of hydride transfer for NADH and its models, a展开更多
文摘Direct chemoselective oxidation of δ-lactones via highly stable benzyl radical cyclization is reported. The one-pot conversion of premade substituted 5-aryl pentanoic acid and 8-benzyl-1-naphthoic acid in the presence of K2S2Os--CuCl2 results to the δ-lactones in moderate to good yields. The advantages of this methodology is using water as a solvent and utilizing available starting materials.
基金supported by the National Natural Science Foundation of China(21376208)the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars of China(LR13B030001)+2 种基金the Specialized Research Fund for the Doctoral Program of Higher Education(J20130060)the Fundamental Research Funds for the Central Universitiesthe Program for Zhejiang Leading Team of S&T Innovation~~
文摘Studies on the mechanism of the reactions involving coenzyme NAD(P)H and its model compounds are of considerable significance for understanding the role and the mechanism of this coenzyme in living cells. Although there have been extensive studies on the mechanism of hydride transfer for NADH and its models, a
