N-Alkylated benzimidazole derivatives have been synthesized via the aza-Michael addition reactions of1H-benzimidazoles to a,b-unsaturated compounds in water and palladium acetate obviously promoted these transformatio...N-Alkylated benzimidazole derivatives have been synthesized via the aza-Michael addition reactions of1H-benzimidazoles to a,b-unsaturated compounds in water and palladium acetate obviously promoted these transformations. The reported method, overcoming the inactivation of palladium under the equivalent nitrogenous conditions, has the advantages of convenient manipulation, atom-economy, as well as environmental friendliness. The bioactive results showed that butyl 3-（5,6-dimethyl-1Hbenzo[d]imidazol-1-yl）propanoate（3c） exhibited excellent inhibitory activity against Bacillus subtilis（MIC = 16 mg/m L） and Bacillus proteus（MIC = 8 mg/m L）. Therefore, this process would facilitate the construction of various potential bioactive compounds based on the benzimidazole scaffold under mild conditions.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21004075,21372186)Beijing National Laboratory of Molecular Sciences(BNLMS)(No.20140130)+1 种基金the Doctoral Fund of Southwest University(No.SWU111075)the Research Funds for the Central Universities(No.XDJK2013C112)
文摘N-Alkylated benzimidazole derivatives have been synthesized via the aza-Michael addition reactions of1H-benzimidazoles to a,b-unsaturated compounds in water and palladium acetate obviously promoted these transformations. The reported method, overcoming the inactivation of palladium under the equivalent nitrogenous conditions, has the advantages of convenient manipulation, atom-economy, as well as environmental friendliness. The bioactive results showed that butyl 3-（5,6-dimethyl-1Hbenzo[d]imidazol-1-yl）propanoate（3c） exhibited excellent inhibitory activity against Bacillus subtilis（MIC = 16 mg/m L） and Bacillus proteus（MIC = 8 mg/m L）. Therefore, this process would facilitate the construction of various potential bioactive compounds based on the benzimidazole scaffold under mild conditions.
