从用户的角度,建立搜索引擎用户满意度测评理论模型,构建搜索引擎用户满意度评价指标体系,以用户满意为标准对搜索引擎进行评价。最后应用问卷调查法以目前使用最为广泛的百度和 Google 中国搜索引擎门户为研究对象进行实证研究。并有...从用户的角度,建立搜索引擎用户满意度测评理论模型,构建搜索引擎用户满意度评价指标体系,以用户满意为标准对搜索引擎进行评价。最后应用问卷调查法以目前使用最为广泛的百度和 Google 中国搜索引擎门户为研究对象进行实证研究。并有针对性的提出搜索引擎的改进措施和发展方案,以期望提高搜索引擎服务水平,丰富其服务内容,最大限度的满足用户需求。展开更多
Official monthly unemployment data is unavailable in China, while intense public interest in unemployment requires timely and accurate information. Using data on web queries from lead search engines in China, Baidu an...Official monthly unemployment data is unavailable in China, while intense public interest in unemployment requires timely and accurate information. Using data on web queries from lead search engines in China, Baidu and Google, I build two indices measuring intensity of online unemployment-related searches. The unemployment-related search indices identify a structural break in the time series between October and November 2008, which corresponds to a turning point indicated by some macroeconomic indicators. The unemployment- related search indices are proven to have significant correlation with Purchasing Managers＇ Employment Indices and a set of macroeconomic indicators that are closely related to changes in unemployment in China. The results of Granger causality analysis show that the unemployment-related search indices can improve predictions of the c indicators. It suggests that unemploy- ment-related searches can potentially provide valuable, timely, and low-cost information for macroeconomic monitoring.展开更多
The nearly 30-year economic growth miracle brings the consequent tremendous poor-rich gap leading strong drives for social transformation in current China. Chinese top leaders have realized to increase the peoples＇ i...The nearly 30-year economic growth miracle brings the consequent tremendous poor-rich gap leading strong drives for social transformation in current China. Chinese top leaders have realized to increase the peoples＇ income, improve quality of life and construct a ＂harmonious society＂ as key missions especially in recent 10 years. How to measure a harmonious society is one important topic as different measures may lead to different development policies. This paper outlines over 10 indices relevant to measure a harmonious society. Some are global indicators, while some are contributed by domestic researchers and arouse debates. Most of those indicators require conducting surveys on social attitudes under micro levels, which is always time consuming with problem of data quality. As Internet technology advances provide ways to record and disseminate fresh community ideas and thoughts conveniently, detecting topics or emotions from on-line public opinions is becoming a trend or one supplement way to overcome those data acquisition problems. This paper discusses one approach to on-line societal risk perception using hot search words and BBS posts. Such a trial aims to provide another way to societal risk perception different from those in traditional socio psychology studies. Challenges are also indicated.展开更多
Huashi Baidu prescription(HSBDF),recommended in the Guideline for the Diagnosis and Treatment of Novel Coronavirus(2019-nCoV)Pneumonia(On Trials,the Seventh Edition),was clinically used to treat severe corona virus di...Huashi Baidu prescription(HSBDF),recommended in the Guideline for the Diagnosis and Treatment of Novel Coronavirus(2019-nCoV)Pneumonia(On Trials,the Seventh Edition),was clinically used to treat severe corona virus disease 2019(COVID-19)with cough,blood-stained sputum,inhibited defecation,red tongue etc.symptoms.This study was aimed to elucidate and profile the knowledge on its chemical constituents and the potential anti-inflammatory effect in vitro.In the study,the chemical constituents in extract of HSBDF were characterized by UPLC-Q-TOF/MS in both negative and positive modes,and the pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assays(ELISA)to determine the effects of HSBDF in lipopolysaccharide(LPS)-stimulated RAW264.7 cells.The results showed that a total of 217 chemical constituents were tentativedly characterized in HSBDF.Moreover,HSBDF could alleviate the expression levels of IL-6 and TNF-αin the cell models,indicating that the antiviral effects of HSBDF might be associated with regulation of the inflammatory cytokines production in RAW264.7 cells.We hope that the results could be served as the basic data for further study of HSBDF on anti-COVID-19 effect.展开更多
The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with high pathogenicity and infectiousness has become a sudden and lethal pandemic worldwide.Currently,there i...The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with high pathogenicity and infectiousness has become a sudden and lethal pandemic worldwide.Currently,there is no accepted specific drug for COVID-19 treatment.Therefore,it is extremely urgent to clarify the pathogenic mechanism and develop effective therapies for patients with COVID-19.According to several reliable reports from China,traditional Chinese medicine(TCM),especially for three Chinese patent medicines and three Chinese medicine formulas,has been demonstrated to effectively alleviate the symptoms of COVID-19 either used alone or in combination with Western medicines.In this review,we systematically summarized and analyzed the pathogenesis of COVID-19,the detailed clinical practice,active ingredients investigation,network pharmacology prediction and underlying mechanism verification of three Chinese patent medicines and three Chinese medicine formulas in the COVID-19 combat.Additionally,we summarized some promising and high-frequency drugs of these prescriptions and discussed their regulatory mechanism,which provides guidance for the development of new drugs against COVID-19.Collectively,by addressing critical challenges,for example,unclear targets and complicated active ingredients of these medicines and formulas,we believe that TCM will represent promising and efficient strategies for curing COVID-19 and related pandemics.展开更多
文摘从用户的角度,建立搜索引擎用户满意度测评理论模型,构建搜索引擎用户满意度评价指标体系,以用户满意为标准对搜索引擎进行评价。最后应用问卷调查法以目前使用最为广泛的百度和 Google 中国搜索引擎门户为研究对象进行实证研究。并有针对性的提出搜索引擎的改进措施和发展方案,以期望提高搜索引擎服务水平,丰富其服务内容,最大限度的满足用户需求。
基金The Project is sponsored by the Scientific Research Foundation for the Retttmed Overseas Chinese Scholars, Ministry of Education of PRC, and supported by Beijing Natural Science Foundation （No. 9144025）. I would like to thank the reviewers who provide insightful comments and suggestions for improving this paper. I also would like to thank the editors who proofread and edit the paper. Without the supportive work of the reviewers and editors, this paper would not have been possible.
文摘Official monthly unemployment data is unavailable in China, while intense public interest in unemployment requires timely and accurate information. Using data on web queries from lead search engines in China, Baidu and Google, I build two indices measuring intensity of online unemployment-related searches. The unemployment-related search indices identify a structural break in the time series between October and November 2008, which corresponds to a turning point indicated by some macroeconomic indicators. The unemployment- related search indices are proven to have significant correlation with Purchasing Managers＇ Employment Indices and a set of macroeconomic indicators that are closely related to changes in unemployment in China. The results of Granger causality analysis show that the unemployment-related search indices can improve predictions of the c indicators. It suggests that unemploy- ment-related searches can potentially provide valuable, timely, and low-cost information for macroeconomic monitoring.
基金supported by National Basic Research Program of China under Grant No.2010CB731405Natural Science Foundation of China under Grant No.71171187
文摘The nearly 30-year economic growth miracle brings the consequent tremendous poor-rich gap leading strong drives for social transformation in current China. Chinese top leaders have realized to increase the peoples＇ income, improve quality of life and construct a ＂harmonious society＂ as key missions especially in recent 10 years. How to measure a harmonious society is one important topic as different measures may lead to different development policies. This paper outlines over 10 indices relevant to measure a harmonious society. Some are global indicators, while some are contributed by domestic researchers and arouse debates. Most of those indicators require conducting surveys on social attitudes under micro levels, which is always time consuming with problem of data quality. As Internet technology advances provide ways to record and disseminate fresh community ideas and thoughts conveniently, detecting topics or emotions from on-line public opinions is becoming a trend or one supplement way to overcome those data acquisition problems. This paper discusses one approach to on-line societal risk perception using hot search words and BBS posts. Such a trial aims to provide another way to societal risk perception different from those in traditional socio psychology studies. Challenges are also indicated.
基金supported by the National Key R&D Program of China(2019YFC1711000)Qi-Huang Scholar of National Traditional Chinese Medicine Leading Talents Support Program(2018)Chief Scientist of Qi-Huang Project of National Traditional Chinese Medicine Inheritance and Innovation"One Hundred Million"Talent Project(2020).
文摘Huashi Baidu prescription(HSBDF),recommended in the Guideline for the Diagnosis and Treatment of Novel Coronavirus(2019-nCoV)Pneumonia(On Trials,the Seventh Edition),was clinically used to treat severe corona virus disease 2019(COVID-19)with cough,blood-stained sputum,inhibited defecation,red tongue etc.symptoms.This study was aimed to elucidate and profile the knowledge on its chemical constituents and the potential anti-inflammatory effect in vitro.In the study,the chemical constituents in extract of HSBDF were characterized by UPLC-Q-TOF/MS in both negative and positive modes,and the pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assays(ELISA)to determine the effects of HSBDF in lipopolysaccharide(LPS)-stimulated RAW264.7 cells.The results showed that a total of 217 chemical constituents were tentativedly characterized in HSBDF.Moreover,HSBDF could alleviate the expression levels of IL-6 and TNF-αin the cell models,indicating that the antiviral effects of HSBDF might be associated with regulation of the inflammatory cytokines production in RAW264.7 cells.We hope that the results could be served as the basic data for further study of HSBDF on anti-COVID-19 effect.
基金supported by the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202006 to XG and XL)Beijing Municipal Science&Technology Commission(No.7212174 to XL)+2 种基金National Natural Science Foundation of China(No.82004045 to XL)Beijing Nova Program of Science&Technology(No.Z191100001119088 to XL)the Young Talents Promotion Project of China Association of Traditional Chinese Medicine(No.2020-QNRC2-01 to XL).
文摘The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with high pathogenicity and infectiousness has become a sudden and lethal pandemic worldwide.Currently,there is no accepted specific drug for COVID-19 treatment.Therefore,it is extremely urgent to clarify the pathogenic mechanism and develop effective therapies for patients with COVID-19.According to several reliable reports from China,traditional Chinese medicine(TCM),especially for three Chinese patent medicines and three Chinese medicine formulas,has been demonstrated to effectively alleviate the symptoms of COVID-19 either used alone or in combination with Western medicines.In this review,we systematically summarized and analyzed the pathogenesis of COVID-19,the detailed clinical practice,active ingredients investigation,network pharmacology prediction and underlying mechanism verification of three Chinese patent medicines and three Chinese medicine formulas in the COVID-19 combat.Additionally,we summarized some promising and high-frequency drugs of these prescriptions and discussed their regulatory mechanism,which provides guidance for the development of new drugs against COVID-19.Collectively,by addressing critical challenges,for example,unclear targets and complicated active ingredients of these medicines and formulas,we believe that TCM will represent promising and efficient strategies for curing COVID-19 and related pandemics.
