Background Atopy is a state of allergy to common antigens and is founded on an immune disturbance of exuberant Th2 activity and IgE production. There is also epidemiologieal and experimental evidence that exposure to ...Background Atopy is a state of allergy to common antigens and is founded on an immune disturbance of exuberant Th2 activity and IgE production. There is also epidemiologieal and experimental evidence that exposure to myeobacteria has the potential to suppress the development of asthma or atopy. Since Thl and Th2 immune mechanisms are significantly antagonistic, it is hypothesized that myeobaeterial exposure may moderate atopie disease by modification of immune responses. Methods One hundred and twenty mild to moderate persistent asthmatics accompanied with allergic rhinitis were randomly divided into four groups with one injection every other day for 18 times for group A with 1 ml of normal saline, B with 0.5 mg of Bacillus Calmette-Guérin polysaccharide nucleotide （BCG-PSN） and C with 1 mg of BCG-PSN, 36 times for group D with 0. 5 mg of BCG-PSN. Markers for the severity of asthma and rhinitis including the amount of inhaled corticosteriod, bronchodilator and oral H1 blocker-loratidine being used to obtain optimal symptomatic control, symptom scores of asthma and allergic rhinitis, peak expiratory flow （PEF）, histamine provocative dose that produces at least a 20% change in forced expiratory volume with in 1 second （PD20-FEV1 ）, blood IgE levels as well as dermatophagoides pteronysinus （DP） and dermatophagoides farinae （DF） skin prick test were measured every visit for 6 months. Results There were no differences for symptom scores of asthma, daily use of bronchodilator, PEF, PD20- FEV1, blood IgE as well as DF and DP skin prick test among the four groups. Score for allergic rhinitis decreased significantly in groups B, C and D on day 36 and 72 as compared with group A （ P 〈 0.05 ）. Score for allergic rhinitis increased after day 72 in group B and C while it was significantly lower in group D （ P 〈 0.05 ）. The patients in group D used less amount of inhaled beclomethosone than other groups （ P 〈 0.05 ） from day 72 after the treatment to day 180. Oral loratadine consumption i展开更多
目的:观察卡介菌多糖核酸注射液在小儿咳嗽变异性哮喘治疗应用的疗效。方法:将本科40例咳嗽变异性哮喘患儿,随机分为治疗组和对照组(各20例)。治疗组给予BCG-PSN+必可酮气雾剂,对照组:给予单用必可酮气雾剂吸入,连续吸入6周,观察疗效,...目的:观察卡介菌多糖核酸注射液在小儿咳嗽变异性哮喘治疗应用的疗效。方法:将本科40例咳嗽变异性哮喘患儿,随机分为治疗组和对照组(各20例)。治疗组给予BCG-PSN+必可酮气雾剂,对照组:给予单用必可酮气雾剂吸入,连续吸入6周,观察疗效,并进行统计学处理。结果:治疗组总有效率为95%,对照组总有效率为70%,统计学处理总有效率有显著差异(P<0.01)。结论:卡介菌多糖核酸(polysaccharide nucleic acidfraction of BCG,BCG-PSN)能有效地控制咳嗽变异性哮喘(CVA)的呼吸道的反复感染,提高免疫功能;与必可酮配合,能有效地控制CVA的复发。展开更多
文摘Background Atopy is a state of allergy to common antigens and is founded on an immune disturbance of exuberant Th2 activity and IgE production. There is also epidemiologieal and experimental evidence that exposure to myeobacteria has the potential to suppress the development of asthma or atopy. Since Thl and Th2 immune mechanisms are significantly antagonistic, it is hypothesized that myeobaeterial exposure may moderate atopie disease by modification of immune responses. Methods One hundred and twenty mild to moderate persistent asthmatics accompanied with allergic rhinitis were randomly divided into four groups with one injection every other day for 18 times for group A with 1 ml of normal saline, B with 0.5 mg of Bacillus Calmette-Guérin polysaccharide nucleotide （BCG-PSN） and C with 1 mg of BCG-PSN, 36 times for group D with 0. 5 mg of BCG-PSN. Markers for the severity of asthma and rhinitis including the amount of inhaled corticosteriod, bronchodilator and oral H1 blocker-loratidine being used to obtain optimal symptomatic control, symptom scores of asthma and allergic rhinitis, peak expiratory flow （PEF）, histamine provocative dose that produces at least a 20% change in forced expiratory volume with in 1 second （PD20-FEV1 ）, blood IgE levels as well as dermatophagoides pteronysinus （DP） and dermatophagoides farinae （DF） skin prick test were measured every visit for 6 months. Results There were no differences for symptom scores of asthma, daily use of bronchodilator, PEF, PD20- FEV1, blood IgE as well as DF and DP skin prick test among the four groups. Score for allergic rhinitis decreased significantly in groups B, C and D on day 36 and 72 as compared with group A （ P 〈 0.05 ）. Score for allergic rhinitis increased after day 72 in group B and C while it was significantly lower in group D （ P 〈 0.05 ）. The patients in group D used less amount of inhaled beclomethosone than other groups （ P 〈 0.05 ） from day 72 after the treatment to day 180. Oral loratadine consumption i
文摘目的:观察卡介菌多糖核酸注射液在小儿咳嗽变异性哮喘治疗应用的疗效。方法:将本科40例咳嗽变异性哮喘患儿,随机分为治疗组和对照组(各20例)。治疗组给予BCG-PSN+必可酮气雾剂,对照组:给予单用必可酮气雾剂吸入,连续吸入6周,观察疗效,并进行统计学处理。结果:治疗组总有效率为95%,对照组总有效率为70%,统计学处理总有效率有显著差异(P<0.01)。结论:卡介菌多糖核酸(polysaccharide nucleic acidfraction of BCG,BCG-PSN)能有效地控制咳嗽变异性哮喘(CVA)的呼吸道的反复感染,提高免疫功能;与必可酮配合,能有效地控制CVA的复发。
