As a traditional concept of Chinese medicine（CM）, the theory of ＂Shen（Kidney） controlling bones＂ has been gradually proven. And in modern allopathic medicine, the multiple mechanisms of bone growth, development ...As a traditional concept of Chinese medicine（CM）, the theory of ＂Shen（Kidney） controlling bones＂ has been gradually proven. And in modern allopathic medicine, the multiple mechanisms of bone growth, development and regeneration align with the theory. Shen deficiency as a pathological condition has a negative effect on the skeleton of body, specifically the disorder of bone homeostasis. Present studies indicate that Shen deficiency shares a common disorder characterized by dysfunction of hypothalamic-pituitary-adrenal（HPA） axis. HPA axis may be an important regulator of bone diseases with abnormal homeostasis. Therefore, we posit the existence of hypothalamic-pituitary-adrenal-osteo-related cells axis： cells that comprise bone tissue（osteo-related cells） are targets under the regulation of HPA axis in disorder of bone homeostasis. Chinese herbs for nourishing Shen have potential in the development of treatments for disorder of bone homeostasis.展开更多
目的:观察尾部悬吊模拟失重及解悬吊后大鼠骨密度及生物力学的变化。方法:20只Wistar雄性大鼠随机分成空白组和模型组。模型组尾部悬吊14d,解悬吊后继续饲养14d,空白组则正常饲养28d。实验第14天活体检测各组大鼠颅骨、T2椎体、L4椎体...目的:观察尾部悬吊模拟失重及解悬吊后大鼠骨密度及生物力学的变化。方法:20只Wistar雄性大鼠随机分成空白组和模型组。模型组尾部悬吊14d,解悬吊后继续饲养14d,空白组则正常饲养28d。实验第14天活体检测各组大鼠颅骨、T2椎体、L4椎体、骨盆、右侧桡尺骨和右侧股骨的骨密度(bone mineral density,BMD);实验第28天处死大鼠,检测右侧股骨及L4椎体BMD及生物力学强度。结果:与空白组相比,实验第14天,模型组大鼠股骨、骨盆、腰椎BMD明显低,差异有统计学意义(P<0.001,P<0.001,P<0.01);颅骨、胸椎、桡尺骨BMD无明显变化(P>0.05)。实验第28天,模型组大鼠股骨、腰椎BMD和股骨最大载荷明显低,差异有统计学意义(P<0.01,P<0.001,P<0.01)。结论:大鼠尾部悬吊14d即可引起骨代谢的紊乱:承重骨骨矿盐大量丢失;即使解悬吊14d后承重骨BMD及力学强度也明显降低,表明骨代谢紊乱短期内不能恢复正常。展开更多
基金Supported by the Major Science and Technology Special Project of Zhejiang Province to TONG Pei-jian(No.2014C03035)the Zhejiang Provincial Major Science and Technology Project of Medical and Health of China to TONG Pei-jian(No.201487674)Cultivation Program for Innovative Talent Graduate Students to XU Tao-tao(No.311100G00901)from Zhejiang Chinese Medical University
文摘As a traditional concept of Chinese medicine（CM）, the theory of ＂Shen（Kidney） controlling bones＂ has been gradually proven. And in modern allopathic medicine, the multiple mechanisms of bone growth, development and regeneration align with the theory. Shen deficiency as a pathological condition has a negative effect on the skeleton of body, specifically the disorder of bone homeostasis. Present studies indicate that Shen deficiency shares a common disorder characterized by dysfunction of hypothalamic-pituitary-adrenal（HPA） axis. HPA axis may be an important regulator of bone diseases with abnormal homeostasis. Therefore, we posit the existence of hypothalamic-pituitary-adrenal-osteo-related cells axis： cells that comprise bone tissue（osteo-related cells） are targets under the regulation of HPA axis in disorder of bone homeostasis. Chinese herbs for nourishing Shen have potential in the development of treatments for disorder of bone homeostasis.
文摘目的:观察尾部悬吊模拟失重及解悬吊后大鼠骨密度及生物力学的变化。方法:20只Wistar雄性大鼠随机分成空白组和模型组。模型组尾部悬吊14d,解悬吊后继续饲养14d,空白组则正常饲养28d。实验第14天活体检测各组大鼠颅骨、T2椎体、L4椎体、骨盆、右侧桡尺骨和右侧股骨的骨密度(bone mineral density,BMD);实验第28天处死大鼠,检测右侧股骨及L4椎体BMD及生物力学强度。结果:与空白组相比,实验第14天,模型组大鼠股骨、骨盆、腰椎BMD明显低,差异有统计学意义(P<0.001,P<0.001,P<0.01);颅骨、胸椎、桡尺骨BMD无明显变化(P>0.05)。实验第28天,模型组大鼠股骨、腰椎BMD和股骨最大载荷明显低,差异有统计学意义(P<0.01,P<0.001,P<0.01)。结论:大鼠尾部悬吊14d即可引起骨代谢的紊乱:承重骨骨矿盐大量丢失;即使解悬吊14d后承重骨BMD及力学强度也明显降低,表明骨代谢紊乱短期内不能恢复正常。
