Diabetes mellitus is an independent risk factor for ischemic stroke.Both diabetes mellitus and stroke are linked to systemic inflammation that aggravates patient outcomes.Stellate ganglion block can effectively regula...Diabetes mellitus is an independent risk factor for ischemic stroke.Both diabetes mellitus and stroke are linked to systemic inflammation that aggravates patient outcomes.Stellate ganglion block can effectively regulate the inflammatory response.Therefore,it is hypothesized that stellate ganglion block could be a potential therapy for ischemic stroke in diabetic subjects.In this study,we induced diabetes mellitus in rats by feeding them a high-fat diet for 4 successive weeks.The left middle cerebral artery was occluded to establish models of ischemic stroke in diabetic rats.Subsequently,we performed left stellate ganglion block with 1%lidocaine using the percutaneous posterior approach 15 minutes before reperfusion and again 20 and 44 hours after reperfusion.Our results showed that stellate ganglion block did not decrease the blood glucose level in diabetic rats with diabetes mellitus but did reduce the cerebral infarct volume and the cerebral water content.It also improved the recovery of neurological function,increased 28-day survival rate,inhibited Toll like receptor 4/nuclear factor kappa B signaling pathway and reduced inflammatory response in the plasma of rats.However,injection of Toll like receptor 4 agonist lipopolysaccharide 5 minutes before stellate ganglion block inhibited the effect of stellate ganglion block,whereas injection of Toll like receptor 4 inhibitor TAK242 had no such effect.We also found that stellate ganglion block performed at night had no positive effect on diabetic ischemic stroke.These findings suggest that stellate ganglion block is a potential therapy for diabetic ischemic stroke and that it may be mediated through the Toll like receptor 4/nuclear factor kappa B signaling pathway.We also found that the therapeutic effect of stellate ganglion block is affected by circadian rhythm.展开更多
liverrelated morbidity and mortality worldwide.It impacts nearly 300 million people.The current treatment for chronic infection with the hepatitis B virus(HBV)is complex and lacks a durable treatment response,especial...liverrelated morbidity and mortality worldwide.It impacts nearly 300 million people.The current treatment for chronic infection with the hepatitis B virus(HBV)is complex and lacks a durable treatment response,especially hepatitis B surface antigen(HBsAg)loss,necessitating indefinite treatment in most CHB patients due to the persistence of HBV covalently closed circular DNA(cccDNA).New drugs that target distinct steps of the HBV life cycle have been investigated,which comprise inhibiting the entry of HBV into hepatocytes,disrupting or silencing HBV cccDNA,modulating nucleocapsid assembly,interfering HBV transcription,and inhibiting HBsAg release.The achievement of a functional cure or sustained HBsAg loss in CHB patients represents the following approach towards HBV eradication.This review will explore the up-to-date advances in the development of new direct-acting anti-HBV drugs.Hopefully,with the combination of the current antiviral drugs and the newly developed direct-acting antiviral drugs targeting the different steps of the HBV life cycle,the ultimate eradication of CHB infection will soon be achieved.展开更多
The positive definiteness of elasticity tensors plays an important role in the elasticity theory.In this paper,we consider the bi-block symmetric tensors,which contain elasticity tensors as a subclass.First,we define ...The positive definiteness of elasticity tensors plays an important role in the elasticity theory.In this paper,we consider the bi-block symmetric tensors,which contain elasticity tensors as a subclass.First,we define the bi-block M-eigenvalue of a bi-block symmetric tensor,and show that a bi-block symmetric tensor is bi-block positive(semi)definite if and only if its smallest bi-block M-eigenvalue is(nonnegative)positive.Then,we discuss the distribution of bi-block M-eigenvalues,by which we get a sufficient condition for judging bi-block positive(semi)definiteness of the bi-block symmetric tensor involved.Particularly,we show that several classes of bi-block symmetric tensors are bi-block positive definite or bi-block positive semidefinite,including bi-block(strictly)diagonally dominant symmetric tensors and bi-block symmetric(B)B0-tensors.These give easily checkable sufficient conditions for judging bi-block positive(semi)definiteness of a bi-block symmetric tensor.As a byproduct,we also obtain two easily checkable sufficient conditions for the strong ellipticity of elasticity tensors.展开更多
In this paper, we focus on the structure of p-blocks with defect group satisfying some specialcondition. These special conditions include: two elements of the defect group are conjugate to each other indefect D if and...In this paper, we focus on the structure of p-blocks with defect group satisfying some specialcondition. These special conditions include: two elements of the defect group are conjugate to each other indefect D if and only if they are conjugate to each other in G; the number of conjugacy classes whose p-partis contained in P by conjugacy is not larger than |P|.展开更多
The general strategy to construct D-A type conjugated polymers is alternating copolymerization of electron-donating(D)monomer and electron-accepting(A)monomer.In this article,we report a new strategy to develop D-A ty...The general strategy to construct D-A type conjugated polymers is alternating copolymerization of electron-donating(D)monomer and electron-accepting(A)monomer.In this article,we report a new strategy to develop D-A type conjugated polymers,i.e.first fuse the D and A units into a polycyclic structure to produce a building block and then polymerize the building block with another unit.We develop a new building block with ladder structure based on B←N unit,B←N bridged dipyridylbenzene(BNDPB).In the skeleton of BNDPB,one diamine-substituted phenylene ring(D unit)and two B←N-linked pyridyl rings(A unit)are fused together to produce the polycyclic structure.Owning to the presence of intramolecular D-A character,the building block itself exhibits narrow bandgap of 1.74 eV.The conjugated polymers based on BNDPB show unique electronic structures,i.e.localized HOMOs and delocalized LUMOs,which are rarely observed for conventional D-A conjugated polymers.The polymers exhibit smaller bandgap than that of the building block BNDPB and display near-infrared(NIR)light absorption(λabs=ca.700 nm).This study thus provides not only a new strategy to design D-A conjugated polymers but also a new kind of building block with narrow bandgap.展开更多
基金The study was approved by Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province,No.LBH-Q18074(to WCY).
文摘Diabetes mellitus is an independent risk factor for ischemic stroke.Both diabetes mellitus and stroke are linked to systemic inflammation that aggravates patient outcomes.Stellate ganglion block can effectively regulate the inflammatory response.Therefore,it is hypothesized that stellate ganglion block could be a potential therapy for ischemic stroke in diabetic subjects.In this study,we induced diabetes mellitus in rats by feeding them a high-fat diet for 4 successive weeks.The left middle cerebral artery was occluded to establish models of ischemic stroke in diabetic rats.Subsequently,we performed left stellate ganglion block with 1%lidocaine using the percutaneous posterior approach 15 minutes before reperfusion and again 20 and 44 hours after reperfusion.Our results showed that stellate ganglion block did not decrease the blood glucose level in diabetic rats with diabetes mellitus but did reduce the cerebral infarct volume and the cerebral water content.It also improved the recovery of neurological function,increased 28-day survival rate,inhibited Toll like receptor 4/nuclear factor kappa B signaling pathway and reduced inflammatory response in the plasma of rats.However,injection of Toll like receptor 4 agonist lipopolysaccharide 5 minutes before stellate ganglion block inhibited the effect of stellate ganglion block,whereas injection of Toll like receptor 4 inhibitor TAK242 had no such effect.We also found that stellate ganglion block performed at night had no positive effect on diabetic ischemic stroke.These findings suggest that stellate ganglion block is a potential therapy for diabetic ischemic stroke and that it may be mediated through the Toll like receptor 4/nuclear factor kappa B signaling pathway.We also found that the therapeutic effect of stellate ganglion block is affected by circadian rhythm.
文摘liverrelated morbidity and mortality worldwide.It impacts nearly 300 million people.The current treatment for chronic infection with the hepatitis B virus(HBV)is complex and lacks a durable treatment response,especially hepatitis B surface antigen(HBsAg)loss,necessitating indefinite treatment in most CHB patients due to the persistence of HBV covalently closed circular DNA(cccDNA).New drugs that target distinct steps of the HBV life cycle have been investigated,which comprise inhibiting the entry of HBV into hepatocytes,disrupting or silencing HBV cccDNA,modulating nucleocapsid assembly,interfering HBV transcription,and inhibiting HBsAg release.The achievement of a functional cure or sustained HBsAg loss in CHB patients represents the following approach towards HBV eradication.This review will explore the up-to-date advances in the development of new direct-acting anti-HBV drugs.Hopefully,with the combination of the current antiviral drugs and the newly developed direct-acting antiviral drugs targeting the different steps of the HBV life cycle,the ultimate eradication of CHB infection will soon be achieved.
基金The first author’s work was supported by the National Natural Science Foundation of China(Grant No.11871051).
文摘The positive definiteness of elasticity tensors plays an important role in the elasticity theory.In this paper,we consider the bi-block symmetric tensors,which contain elasticity tensors as a subclass.First,we define the bi-block M-eigenvalue of a bi-block symmetric tensor,and show that a bi-block symmetric tensor is bi-block positive(semi)definite if and only if its smallest bi-block M-eigenvalue is(nonnegative)positive.Then,we discuss the distribution of bi-block M-eigenvalues,by which we get a sufficient condition for judging bi-block positive(semi)definiteness of the bi-block symmetric tensor involved.Particularly,we show that several classes of bi-block symmetric tensors are bi-block positive definite or bi-block positive semidefinite,including bi-block(strictly)diagonally dominant symmetric tensors and bi-block symmetric(B)B0-tensors.These give easily checkable sufficient conditions for judging bi-block positive(semi)definiteness of a bi-block symmetric tensor.As a byproduct,we also obtain two easily checkable sufficient conditions for the strong ellipticity of elasticity tensors.
基金This work was supported by the National Natural Science Foundation of China (Grant No. 19831070) and BNSF (1992003).
文摘In this paper, we focus on the structure of p-blocks with defect group satisfying some specialcondition. These special conditions include: two elements of the defect group are conjugate to each other indefect D if and only if they are conjugate to each other in G; the number of conjugacy classes whose p-partis contained in P by conjugacy is not larger than |P|.
基金supported by the National Natural Science Foundation of China (21625403, 21822507, 21875244, 21761132020, 21574129)National Key Research and Development Program of China (2018YFE0100600)+2 种基金funded by MOST and Strategic Priority Research Program of CAS (XDB12010200)Youth Innovation Promotion Association of CAS (2017265)State Key Laboratory of Supramolecular Structure and Materials in Jilin University (sklssm201905)
文摘The general strategy to construct D-A type conjugated polymers is alternating copolymerization of electron-donating(D)monomer and electron-accepting(A)monomer.In this article,we report a new strategy to develop D-A type conjugated polymers,i.e.first fuse the D and A units into a polycyclic structure to produce a building block and then polymerize the building block with another unit.We develop a new building block with ladder structure based on B←N unit,B←N bridged dipyridylbenzene(BNDPB).In the skeleton of BNDPB,one diamine-substituted phenylene ring(D unit)and two B←N-linked pyridyl rings(A unit)are fused together to produce the polycyclic structure.Owning to the presence of intramolecular D-A character,the building block itself exhibits narrow bandgap of 1.74 eV.The conjugated polymers based on BNDPB show unique electronic structures,i.e.localized HOMOs and delocalized LUMOs,which are rarely observed for conventional D-A conjugated polymers.The polymers exhibit smaller bandgap than that of the building block BNDPB and display near-infrared(NIR)light absorption(λabs=ca.700 nm).This study thus provides not only a new strategy to design D-A conjugated polymers but also a new kind of building block with narrow bandgap.
