An efficient and novel methodology to access phenolic glycosides has been established by using coppermediated coupling reaction of aryl boronic acids with hemiacetals.The reaction takes place normally in the presence ...An efficient and novel methodology to access phenolic glycosides has been established by using coppermediated coupling reaction of aryl boronic acids with hemiacetals.The reaction takes place normally in the presence of Cu(OAc)_2(1.0 equiv.)and pyridine(2.0 equiv.)at 40℃.This protocol distinguishes itself by wide substrate scope,operational simplicity and giving rise to a myriad of phenolic glycosides in good to excellent yields.展开更多
A facile,one-pot synthesis of N-aryl propargylamine from aromatic boronic acid,aqueous ammonia,and propargyl bromide has been achieved under microwave-assisted conditions.The reactions can be smoothly completed within...A facile,one-pot synthesis of N-aryl propargylamine from aromatic boronic acid,aqueous ammonia,and propargyl bromide has been achieved under microwave-assisted conditions.The reactions can be smoothly completed within a total 10 min through a two-step procedure,including copper-catalyzed coupling of aromatic boronic acids with aqueous ammonia and following propargylation by propargyl bromide.展开更多
基金financially supported by the National Key R&D Program of China (No. 2018YFA0507602)the National Natural Science Foundation of China (Nos. 21572012, 21772006)the State Key Laboratory of Drug Research (No. SIMM1803KF-02)
文摘An efficient and novel methodology to access phenolic glycosides has been established by using coppermediated coupling reaction of aryl boronic acids with hemiacetals.The reaction takes place normally in the presence of Cu(OAc)_2(1.0 equiv.)and pyridine(2.0 equiv.)at 40℃.This protocol distinguishes itself by wide substrate scope,operational simplicity and giving rise to a myriad of phenolic glycosides in good to excellent yields.
基金the National Natural Science Foundation of China (No. 21262020)the Science and Technology Planning Project of Yunnan Province (No. KKSY201207140)+1 种基金the Natural Science Foundation of Yunnan Education Department (No. 09Y0081)the Analysis and Measurement Foundation of Kunming University of Science and Technology (No. 20130560) for their financial supports
文摘A facile,one-pot synthesis of N-aryl propargylamine from aromatic boronic acid,aqueous ammonia,and propargyl bromide has been achieved under microwave-assisted conditions.The reactions can be smoothly completed within a total 10 min through a two-step procedure,including copper-catalyzed coupling of aromatic boronic acids with aqueous ammonia and following propargylation by propargyl bromide.
