We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group ...We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group （n=397, BMI〈24 kg/m2） and the overweight group （n=400, BMI〉24 kg/m2）. Our results showed that the overweight group had higher blood pressure [（130.15±19.01） mmHg vs （123.66±18.70） mmHg] and higher levels of blood sugar [（7.09±2.89） mmol/L vs （6.21±2.59） mmol/L], triglyceride [（1.93±1.19） mmol/L vs （1.44 ±0.85） mmol/L], total cholesterol [（4.26±1.06） mmol/L vs （4.09±0.99） mmol/L], low-density lipoprotein cholesterol （LDL-C） [（2.56±0.75） mmol/L vs （2.39±0.72） mmol/L], and apoB [（0.83±0.27） mg/L vs （0.78±0.23） mg/L], and a higher apoB/apoA1 ratio （0.83 ±0.27 vs 0.75±0.25） and lower levels high-density lipoprotein cholesterol [（1.10±0.26） mmol/L vs （1.21±0.31） mmol/L] and apoA1 [（1.04±0.20） mg/L vs （1.08±0.22） mg/L] than those of the normal weight group （all P 〈 0.05）. The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the lowest apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve （AUC） was the highest for apoB/apoA1 （0.655）. The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.展开更多
Background: Metabolic syndrome is the major cause for life threatening disorders such as cardiovascular diseases and type 2 diabetes. These disorders are associated with hyperuricemia and the number is growing among t...Background: Metabolic syndrome is the major cause for life threatening disorders such as cardiovascular diseases and type 2 diabetes. These disorders are associated with hyperuricemia and the number is growing among the urban population. Methods: A cross sectional study was done among Kodava population by conducting health camps in Mysore district. Metabolic syndrome was defined according to Joint Interim Statement criteria. Anthropometry was done and blood pressure readings were noted. Clinical markers like fasting glucose, triglyceride, high density lipoprotein, CVD markers and uric acid levels were analyzed. Results: The prevalence of metabolic syndrome was 60.77% and the utmost occurrence was in 41 - 60 age groups. Women were more affected than men (31.58%) and MetS became pronounced with advance of age. Biochemical levels of C-reactive protein, ApolipoproteinB/ApolipoproteinA1 ratio and uric acid wereraised (P < 0.05) and the severity correlated with the number of components of metabolic syndrome. Conclusions: This study helped in identifying new subjects with metabolic syndrome wherein, abdominal obesity was the most common abnormality followed by elevated fasting glucose. Female subjects and subjects with increased waist circumference along with mid aged people are more susceptible to MetS which amplified their CVD risk factors and hyperuricemic conditions. Life style modifications and therapeutic approach are critical prerequisite. However, there is an urgent need for further health camps for the awareness, and prevention of MetS and its associated risk factors among Kodavas.展开更多
基金supported by National High-Tech Research and Development Program of China (No.2006AA02A406)Natural Science Foundation of China (No.30871042)
文摘We investigated the relationship of apoB/apoA1 ratio and coronary heart disease （CHD） in persons who were overweight or obese. The subjects were divided by the body mass indexes （BMI） into the normal weight group （n=397, BMI〈24 kg/m2） and the overweight group （n=400, BMI〉24 kg/m2）. Our results showed that the overweight group had higher blood pressure [（130.15±19.01） mmHg vs （123.66±18.70） mmHg] and higher levels of blood sugar [（7.09±2.89） mmol/L vs （6.21±2.59） mmol/L], triglyceride [（1.93±1.19） mmol/L vs （1.44 ±0.85） mmol/L], total cholesterol [（4.26±1.06） mmol/L vs （4.09±0.99） mmol/L], low-density lipoprotein cholesterol （LDL-C） [（2.56±0.75） mmol/L vs （2.39±0.72） mmol/L], and apoB [（0.83±0.27） mg/L vs （0.78±0.23） mg/L], and a higher apoB/apoA1 ratio （0.83 ±0.27 vs 0.75±0.25） and lower levels high-density lipoprotein cholesterol [（1.10±0.26） mmol/L vs （1.21±0.31） mmol/L] and apoA1 [（1.04±0.20） mg/L vs （1.08±0.22） mg/L] than those of the normal weight group （all P 〈 0.05）. The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoA1 quartile, compared with the subjects in the lowest apoB/apoA1 quartile. The higher apoB/apoA1 quartile was in agreement with the higher prevalence of CHD. In the overweight and obesity group, the area under ROC curve （AUC） was the highest for apoB/apoA1 （0.655）. The cut-off point of apoB/apoA1 for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19% and a specificity of 71.72%. In conclusion, apoB and apoA1 were simple clinical indicators, and the apoB/apoA1 ratio was closely related with CHD in overweight and obese patients. The apoB/apoA1 ratio may provide some useful information in the differential diagnosis.
文摘Background: Metabolic syndrome is the major cause for life threatening disorders such as cardiovascular diseases and type 2 diabetes. These disorders are associated with hyperuricemia and the number is growing among the urban population. Methods: A cross sectional study was done among Kodava population by conducting health camps in Mysore district. Metabolic syndrome was defined according to Joint Interim Statement criteria. Anthropometry was done and blood pressure readings were noted. Clinical markers like fasting glucose, triglyceride, high density lipoprotein, CVD markers and uric acid levels were analyzed. Results: The prevalence of metabolic syndrome was 60.77% and the utmost occurrence was in 41 - 60 age groups. Women were more affected than men (31.58%) and MetS became pronounced with advance of age. Biochemical levels of C-reactive protein, ApolipoproteinB/ApolipoproteinA1 ratio and uric acid wereraised (P < 0.05) and the severity correlated with the number of components of metabolic syndrome. Conclusions: This study helped in identifying new subjects with metabolic syndrome wherein, abdominal obesity was the most common abnormality followed by elevated fasting glucose. Female subjects and subjects with increased waist circumference along with mid aged people are more susceptible to MetS which amplified their CVD risk factors and hyperuricemic conditions. Life style modifications and therapeutic approach are critical prerequisite. However, there is an urgent need for further health camps for the awareness, and prevention of MetS and its associated risk factors among Kodavas.
