Objective To observe the effects of anti fecundity and anti embryonation immuntiy of anti idiotypic monoclonal antibody NP30 of Schistosoma japonicum on female adult worm Methods The active immunization ...Objective To observe the effects of anti fecundity and anti embryonation immuntiy of anti idiotypic monoclonal antibody NP30 of Schistosoma japonicum on female adult worm Methods The active immunization of C57BL/6 mice was conducted by means of three intraperitoneal injections of NP30 The control group was injected with SP2/0 ascites intraperitoneally Results On the twenty seventh day after challenge infection, the number of eggs in the liver tissue and in uterus of the group immunized with NP30 decreased by 30 91% and by 38 55%, respectively On the thirty ninth day after the challenge infection, the number of mature eggs in the liver tissue of the group immunized with NP30 decreased by 66 63% and the number of dead eggs increased by 60 66% Conclusions NP30, with which mice were actively immunized, possesses double effects of anti fecundity and anti embryonation immunity on female adult worm of Schistosoma japonicum , therefore it can be used as a promising candidate of anti pathologic vaccine molecule against Schistosomiasis japonica展开更多
文摘Objective To observe the effects of anti fecundity and anti embryonation immuntiy of anti idiotypic monoclonal antibody NP30 of Schistosoma japonicum on female adult worm Methods The active immunization of C57BL/6 mice was conducted by means of three intraperitoneal injections of NP30 The control group was injected with SP2/0 ascites intraperitoneally Results On the twenty seventh day after challenge infection, the number of eggs in the liver tissue and in uterus of the group immunized with NP30 decreased by 30 91% and by 38 55%, respectively On the thirty ninth day after the challenge infection, the number of mature eggs in the liver tissue of the group immunized with NP30 decreased by 66 63% and the number of dead eggs increased by 60 66% Conclusions NP30, with which mice were actively immunized, possesses double effects of anti fecundity and anti embryonation immunity on female adult worm of Schistosoma japonicum , therefore it can be used as a promising candidate of anti pathologic vaccine molecule against Schistosomiasis japonica
