扁桃体手术在公元1世纪就有记录,从最初粗暴切除到20世纪的精细剥离,并发症和出血大为减少。而最早的腺样体手术则为19世纪60年代由丹麦医生Hans Wilhelm Meyer实施的。20世纪90年代开启了直视下腺样体手术新时期。进入21世纪,基于剥离...扁桃体手术在公元1世纪就有记录,从最初粗暴切除到20世纪的精细剥离,并发症和出血大为减少。而最早的腺样体手术则为19世纪60年代由丹麦医生Hans Wilhelm Meyer实施的。20世纪90年代开启了直视下腺样体手术新时期。进入21世纪,基于剥离原理的电刀、激光、等离子射频消融等扁桃体和腺样体切除方式得到了推广和普及。低温等离子射频消融技术利用超低频率100kHz射频交变电流激发氯化钠递质形成等离子体,直接作用于靶组织,打断组织细胞间的分子键,使之裂解和气化,其工作温度维持在40~70℃,有效降低了正常组织的高温损伤,符合微创的理念。因其切除的精准性和低出血量等优势,正为越来越多的业界同道所推崇。展开更多
Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most b...Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features.展开更多
Aim To detect the expression of nerve growth factor （NGF） and vascular endothelial growth factor （VEGF） in salivary adenoid cystic carcinoma （SACC） tissues, as well as to determine the correlation between growth...Aim To detect the expression of nerve growth factor （NGF） and vascular endothelial growth factor （VEGF） in salivary adenoid cystic carcinoma （SACC） tissues, as well as to determine the correlation between growth factor expression and prognosis in SACC. Methodology Medical records of 63 patients surgically treated for SACC between January 1988 and October 2005 were reviewed. Immunohistochemistry was performed to examine the expression of NGF and VEGF in tumor tissues. Kaplan-Meier analysis and Cox＇s proportional hazard regression model were applied to assess predictors of survival. Results NGF and VEGF were overexpressed in SACC tissues, compared with those in normal salivary tissues （P〈0.05）, and the staining intensity of these two factors was stronger in groups of solid subtype, advanced TNM stage, perineural invasion and recurrence. Patients with high- expression of NGF and VEGF, solid subtype, advanced stage, perineural invasion, recurrence and extended resection alone had worse survival rates （P〈0.05）. Conclusion NGF and VEGF are expressed increasingly in the tissues of SACC cases with invasion and metastasis. NGF expression and VEGF expression are independent prognosis factors for survival.展开更多
文摘扁桃体手术在公元1世纪就有记录,从最初粗暴切除到20世纪的精细剥离,并发症和出血大为减少。而最早的腺样体手术则为19世纪60年代由丹麦医生Hans Wilhelm Meyer实施的。20世纪90年代开启了直视下腺样体手术新时期。进入21世纪,基于剥离原理的电刀、激光、等离子射频消融等扁桃体和腺样体切除方式得到了推广和普及。低温等离子射频消融技术利用超低频率100kHz射频交变电流激发氯化钠递质形成等离子体,直接作用于靶组织,打断组织细胞间的分子键,使之裂解和气化,其工作温度维持在40~70℃,有效降低了正常组织的高温损伤,符合微创的理念。因其切除的精准性和低出血量等优势,正为越来越多的业界同道所推崇。
文摘Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features.
基金supported by National Natural Science Foundation of China (30060082)Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ([2003] 593)+3 种基金Key Research Project Foundation of Guangxi Health Bureau (200006)Guangxi Science Foundation for Returned Overseas Scholars (0836013)Educational Scientific Research Foundation of Chinese Society of Higher Education (06AIL077 0110)Innovation Project of Guangxi Graduate Education (2009105981003M174)
文摘Aim To detect the expression of nerve growth factor （NGF） and vascular endothelial growth factor （VEGF） in salivary adenoid cystic carcinoma （SACC） tissues, as well as to determine the correlation between growth factor expression and prognosis in SACC. Methodology Medical records of 63 patients surgically treated for SACC between January 1988 and October 2005 were reviewed. Immunohistochemistry was performed to examine the expression of NGF and VEGF in tumor tissues. Kaplan-Meier analysis and Cox＇s proportional hazard regression model were applied to assess predictors of survival. Results NGF and VEGF were overexpressed in SACC tissues, compared with those in normal salivary tissues （P〈0.05）, and the staining intensity of these two factors was stronger in groups of solid subtype, advanced TNM stage, perineural invasion and recurrence. Patients with high- expression of NGF and VEGF, solid subtype, advanced stage, perineural invasion, recurrence and extended resection alone had worse survival rates （P〈0.05）. Conclusion NGF and VEGF are expressed increasingly in the tissues of SACC cases with invasion and metastasis. NGF expression and VEGF expression are independent prognosis factors for survival.
