A new diterpenoid was isolated from the ethanolic extract of the dried root bark of Tripterygium wilfordii Hook.f. It is the first example of abietane diterpenoid glycoside isolated from Tripterygium wilfordii Hook.f...A new diterpenoid was isolated from the ethanolic extract of the dried root bark of Tripterygium wilfordii Hook.f. It is the first example of abietane diterpenoid glycoside isolated from Tripterygium wilfordii Hook.f. Its structure was identified to be 11-O-b-D-glucopyranosyl- neotriptophenolide based on spectral methods.展开更多
The structure of a new abietane diterpenoid, taxayunnin (1), from the barks of Taxus yunnanensis, was determined by spectroscopic analysis. A known abietane diterpenoid, taxamairin C (2), was also isolated.
A new ent-abietane diterpenoid, named dayecrystal C, was isolated from the EtOAc extract of the dried leaves of Isodon macrophyllus. Its structure was determined on the basis of spectroscopic methods.
A new abietane diterpenoid, orthosiphonol (11-methoxy-12, 14-dihydroxy-8, 11, 13-abieta trien-7-one) (1) together with known 11-hydroxysugiol (2) were isolated from Orthosiphon wulfenioides. Their structures were det...A new abietane diterpenoid, orthosiphonol (11-methoxy-12, 14-dihydroxy-8, 11, 13-abieta trien-7-one) (1) together with known 11-hydroxysugiol (2) were isolated from Orthosiphon wulfenioides. Their structures were determined on the basis of spectroscopic evidence.展开更多
Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distich...Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distichum cones and their biological properties evaluated in vitro against six different biological screening targets. Taxodione showed potent activity against a number of different targets, and salvinolone and 14-deoxycoleon U showed remarkable inhibitory activities against prolyl oligopeptidase (POP) and 17α-hydroxylase/C17,20-lyase (CYP17), respectively. These three compounds also showed strong cytotoxic activities against HL60 and K562 human leukemia cells. The structure-activity relationships of these compounds have also been considered. The findings in this study could lead to enhanced pharmacological prospects for the natural abietane-type diterpenoids consisting in conifer cones.展开更多
Objective:To explore the traditional use of Juniperus phoenicea L.(J.phoenicea)growing in Egypt as antidiabetic herb.Methods:The antihyperglycemic activities of the crude 80%ethanol and successive extracts of leaves a...Objective:To explore the traditional use of Juniperus phoenicea L.(J.phoenicea)growing in Egypt as antidiabetic herb.Methods:The antihyperglycemic activities of the crude 80%ethanol and successive extracts of leaves and fruits of the plant were investigated in alloxan-induced diabetic rats after collecting blood samples through retro-orbital puncture technique.As a consequence of the biological results,phytochemical investigation of the chloroform fraction of fruits was carried out by column chromatography and thin layer chromatography.Results:Results revealed the reduction in blood glucose levels in rats,which were significantly different from control at 4 and 8 weeks(P<0.01).The highest antihyperglycemic activity was exhibited by the crude extracts of fruits and leaves of which the potency was 83.6%and 81.9%,respectively,after 8 weeks,comparing to metformin drug(100%potency).Chloroform fractions of leaves and fruits were the most potent fractions(potencies were 70.3%,71.4%),respectively,along with ethyl acetate fraction of fruits(71.4%).Phytochemical investigating of the chloroform fraction of fruits resulted in the isolation and identification of 5 abietane diterpenoids.Ferruginol,7-dehydroabietanone,sugiol,6-α-hydroxy-7-oxoferruginol,totarolone and a labdane diterpenoid,varodiol were isolated for the first time from the fruits of J.phoenicea growing in Egypt.The identification of these compounds was based on spectroscopic analysis:1hydrogen-nuclear magnetic resonance and electron impact mass spectrometry,comparing the results with the literature.Conclusions:It has become clear that leaves and fruits of the Egyptian J.phoenicea provide effective antihyperglycemic action in diabetic rats as was reported in folk medicine.The high contents of terpenoids in the non-polar fractions may attribute to the antidiabetic effect of the plant.展开更多
从黄鞘蕊花(Coleus xanthanthus C. Y. Wuet Y. C. Huang)中分得8种成分。其中1个是新的醌式二萜,命名为黄鞘蕊花甲素,其结构为17-methyl(15→16)abieo-16-methoxy-2α-acetoxy-coleon U.7个已知化合物。coleon U(2),sugiol(3),β—谷甾...从黄鞘蕊花(Coleus xanthanthus C. Y. Wuet Y. C. Huang)中分得8种成分。其中1个是新的醌式二萜,命名为黄鞘蕊花甲素,其结构为17-methyl(15→16)abieo-16-methoxy-2α-acetoxy-coleon U.7个已知化合物。coleon U(2),sugiol(3),β—谷甾醇,胡萝卜甙,三十三烷醇,三十三烷和二十八烷酸。展开更多
Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diket...Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diketone（3） were isolated from the whole herbs of Selaginella involven Spring.The structures were elucidated by spectroscopic analyses including UV,IR,1D,2D NMR and MS methods.Additionally,these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.展开更多
文摘A new diterpenoid was isolated from the ethanolic extract of the dried root bark of Tripterygium wilfordii Hook.f. It is the first example of abietane diterpenoid glycoside isolated from Tripterygium wilfordii Hook.f. Its structure was identified to be 11-O-b-D-glucopyranosyl- neotriptophenolide based on spectral methods.
基金This project was supported by the National Natural Science Foundation of China (3950081)theYoung Academic and Technical Leader Raising Foundation of Yunnan Province (awarded to H.-J.Zhang.) the Special Supported Bioscience and Biotechnique Foundation of Academic Sinica(STZ-11).
文摘The structure of a new abietane diterpenoid, taxayunnin (1), from the barks of Taxus yunnanensis, was determined by spectroscopic analysis. A known abietane diterpenoid, taxamairin C (2), was also isolated.
文摘A new ent-abietane diterpenoid, named dayecrystal C, was isolated from the EtOAc extract of the dried leaves of Isodon macrophyllus. Its structure was determined on the basis of spectroscopic methods.
文摘A new abietane diterpenoid, orthosiphonol (11-methoxy-12, 14-dihydroxy-8, 11, 13-abieta trien-7-one) (1) together with known 11-hydroxysugiol (2) were isolated from Orthosiphon wulfenioides. Their structures were determined on the basis of spectroscopic evidence.
文摘Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distichum cones and their biological properties evaluated in vitro against six different biological screening targets. Taxodione showed potent activity against a number of different targets, and salvinolone and 14-deoxycoleon U showed remarkable inhibitory activities against prolyl oligopeptidase (POP) and 17α-hydroxylase/C17,20-lyase (CYP17), respectively. These three compounds also showed strong cytotoxic activities against HL60 and K562 human leukemia cells. The structure-activity relationships of these compounds have also been considered. The findings in this study could lead to enhanced pharmacological prospects for the natural abietane-type diterpenoids consisting in conifer cones.
文摘Objective:To explore the traditional use of Juniperus phoenicea L.(J.phoenicea)growing in Egypt as antidiabetic herb.Methods:The antihyperglycemic activities of the crude 80%ethanol and successive extracts of leaves and fruits of the plant were investigated in alloxan-induced diabetic rats after collecting blood samples through retro-orbital puncture technique.As a consequence of the biological results,phytochemical investigation of the chloroform fraction of fruits was carried out by column chromatography and thin layer chromatography.Results:Results revealed the reduction in blood glucose levels in rats,which were significantly different from control at 4 and 8 weeks(P<0.01).The highest antihyperglycemic activity was exhibited by the crude extracts of fruits and leaves of which the potency was 83.6%and 81.9%,respectively,after 8 weeks,comparing to metformin drug(100%potency).Chloroform fractions of leaves and fruits were the most potent fractions(potencies were 70.3%,71.4%),respectively,along with ethyl acetate fraction of fruits(71.4%).Phytochemical investigating of the chloroform fraction of fruits resulted in the isolation and identification of 5 abietane diterpenoids.Ferruginol,7-dehydroabietanone,sugiol,6-α-hydroxy-7-oxoferruginol,totarolone and a labdane diterpenoid,varodiol were isolated for the first time from the fruits of J.phoenicea growing in Egypt.The identification of these compounds was based on spectroscopic analysis:1hydrogen-nuclear magnetic resonance and electron impact mass spectrometry,comparing the results with the literature.Conclusions:It has become clear that leaves and fruits of the Egyptian J.phoenicea provide effective antihyperglycemic action in diabetic rats as was reported in folk medicine.The high contents of terpenoids in the non-polar fractions may attribute to the antidiabetic effect of the plant.
文摘从黄鞘蕊花(Coleus xanthanthus C. Y. Wuet Y. C. Huang)中分得8种成分。其中1个是新的醌式二萜,命名为黄鞘蕊花甲素,其结构为17-methyl(15→16)abieo-16-methoxy-2α-acetoxy-coleon U.7个已知化合物。coleon U(2),sugiol(3),β—谷甾醇,胡萝卜甙,三十三烷醇,三十三烷和二十八烷酸。
基金supported by National Natural Science Foundation (No. 31370370)the Doctoral Program Foundation of Institutions of Higher Education of China (No. 20100162110057)Chinese Medicine Research Program of Hunan Province (Nos. 2009059 and 2010004)
文摘Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diketone（3） were isolated from the whole herbs of Selaginella involven Spring.The structures were elucidated by spectroscopic analyses including UV,IR,1D,2D NMR and MS methods.Additionally,these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.
