Active exoskeletons have been widely investigated to supplement and restore human hand movements,but a significant limitation is that they have a complicated design requiring multi actuators.Single Degree-Of-Freedom(D...Active exoskeletons have been widely investigated to supplement and restore human hand movements,but a significant limitation is that they have a complicated design requiring multi actuators.Single Degree-Of-Freedom(DOF)planar linkage mechanisms could be used with simple control.This research represents the design and optimization of a mechanism proposed for a finger exoskeleton bionic device.One DOF six-bar linkage Stephenson-II is selected,and a motion-generation mechanism synthesis problem is defined.The design is based on the data obtained from the flexion/extension motion of the index finger through 16 precision points and 16 angles for each phalange associated with the fingertip position.After explaining the kinematic analysis of the Stephenson-II,an evaluation of swarm intelligence techniques,including PSO,GWO,and ARO algorithms for solving optimization problems,is presented.ARO algorithm demonstrates the best performance among them.Moreover,the optimized mechanism in this study has a 50% error reduction compared to the one previously designed(Bataller et al.in Mech Mach Theory 105:31-43,2016).展开更多
石骨症也称阿耳伯斯·尚堡氏病(Albers Schonberg disease)、大理石骨病(Marble bone disease)等,是一种以骨吸收障碍导致的广泛骨密度增加为标志的罕见疾病,主要与破骨细胞(OCL)功能障碍有关。最近的研究证实了石骨症具有高度的遗...石骨症也称阿耳伯斯·尚堡氏病(Albers Schonberg disease)、大理石骨病(Marble bone disease)等,是一种以骨吸收障碍导致的广泛骨密度增加为标志的罕见疾病,主要与破骨细胞(OCL)功能障碍有关。最近的研究证实了石骨症具有高度的遗传异质性,涉及多种基因突变(TCIRG1、CLCN7、SNX10、OSTM1、PLEKHM1、CAII、RANKL、RANK)。然而,仍有超过25%的患者发病于未知类型的基因突变。分选连接蛋白10型(SNX10)是一种新发现的石骨症相关因子。为含PX结构域的分选连接蛋白亚型,参与破骨重吸收过程中质子泵(V-ATPase)的囊泡运输,从而导致重吸收过程的H+分泌障碍,即严重的OCL丰富型常染色体隐性石骨症(ARO)。本文主要从SNX10的功能、SNX10已知的突变类型、临床病例及治疗等方面,针对SNX10与石骨症关系进行系统的阐述。展开更多
本文以电弧参数测量和光学流动显示相结合的方法,对六氟化硫(SF_6)电弧的热边界区进行了研究。在实验中拍摄了电弧拉出喷口时的形象与气流场光学图象。运用 Abel 转换方法计算了热边界区内气体密度与温度分布。研究发现,在燃弧绝大部分...本文以电弧参数测量和光学流动显示相结合的方法,对六氟化硫(SF_6)电弧的热边界区进行了研究。在实验中拍摄了电弧拉出喷口时的形象与气流场光学图象。运用 Abel 转换方法计算了热边界区内气体密度与温度分布。研究发现,在燃弧绝大部分时间,热边界区阻塞喷口,造成流量严重下降。同时,热区气体吸收了大量电弧能量。干涉图片还显示,热区直径在随电流变化中有明显滞止现象。热滞止效应使热区在电流零后可维持较长时间,从而造成了对介质恢复过程的影响。展开更多
文摘Active exoskeletons have been widely investigated to supplement and restore human hand movements,but a significant limitation is that they have a complicated design requiring multi actuators.Single Degree-Of-Freedom(DOF)planar linkage mechanisms could be used with simple control.This research represents the design and optimization of a mechanism proposed for a finger exoskeleton bionic device.One DOF six-bar linkage Stephenson-II is selected,and a motion-generation mechanism synthesis problem is defined.The design is based on the data obtained from the flexion/extension motion of the index finger through 16 precision points and 16 angles for each phalange associated with the fingertip position.After explaining the kinematic analysis of the Stephenson-II,an evaluation of swarm intelligence techniques,including PSO,GWO,and ARO algorithms for solving optimization problems,is presented.ARO algorithm demonstrates the best performance among them.Moreover,the optimized mechanism in this study has a 50% error reduction compared to the one previously designed(Bataller et al.in Mech Mach Theory 105:31-43,2016).
文摘石骨症也称阿耳伯斯·尚堡氏病(Albers Schonberg disease)、大理石骨病(Marble bone disease)等,是一种以骨吸收障碍导致的广泛骨密度增加为标志的罕见疾病,主要与破骨细胞(OCL)功能障碍有关。最近的研究证实了石骨症具有高度的遗传异质性,涉及多种基因突变(TCIRG1、CLCN7、SNX10、OSTM1、PLEKHM1、CAII、RANKL、RANK)。然而,仍有超过25%的患者发病于未知类型的基因突变。分选连接蛋白10型(SNX10)是一种新发现的石骨症相关因子。为含PX结构域的分选连接蛋白亚型,参与破骨重吸收过程中质子泵(V-ATPase)的囊泡运输,从而导致重吸收过程的H+分泌障碍,即严重的OCL丰富型常染色体隐性石骨症(ARO)。本文主要从SNX10的功能、SNX10已知的突变类型、临床病例及治疗等方面,针对SNX10与石骨症关系进行系统的阐述。
文摘本文以电弧参数测量和光学流动显示相结合的方法,对六氟化硫(SF_6)电弧的热边界区进行了研究。在实验中拍摄了电弧拉出喷口时的形象与气流场光学图象。运用 Abel 转换方法计算了热边界区内气体密度与温度分布。研究发现,在燃弧绝大部分时间,热边界区阻塞喷口,造成流量严重下降。同时,热区气体吸收了大量电弧能量。干涉图片还显示,热区直径在随电流变化中有明显滞止现象。热滞止效应使热区在电流零后可维持较长时间,从而造成了对介质恢复过程的影响。
