Arthropod-borne viruses cause serious threats to human health and global agriculture by rapidly spreading via insect vectors. Southern rice black-streaked dwarf virus (SRBSDV) is the most damaging rice-infecting virus...Arthropod-borne viruses cause serious threats to human health and global agriculture by rapidly spreading via insect vectors. Southern rice black-streaked dwarf virus (SRBSDV) is the most damaging rice-infecting virus that is frequently transmitted by planthoppers. However, the molecular mechanisms underlying its propagation in the host plants and epidemics in the field are largely unknown. Here, we showed that the SRBSDV-encoded P6 protein is a key effector that regulates rice ethylene signaling to coordinate viral infection and transmission. In early SRBSDV infection, P6 interacts with OsRTH2 in the cytoplasm to activate ethylene signaling and enhance SRBSDV proliferation;this also repels the insect vector to reduce infestation. In late infection, P6 enters the nucleus, where it interacts with OsEIL2, a key transcription factor of ethylene signaling. The P6-OsEIL2 interaction suppresses ethylene signaling by preventing the dimerization of OsEIL2, thereby facilitating viral transmission by attracting the insect vector. Collectively, these findings reveal a novel molecular mechanism by which an arbovirus modulates the host defense system to promote viral infection and transmission.展开更多
The COVID-19 pandemic has changed the focus of authorities and health organizations with respect to other infectious diseases. This review aims to examine the changes in global epidemiological parameters related to Zi...The COVID-19 pandemic has changed the focus of authorities and health organizations with respect to other infectious diseases. This review aims to examine the changes in global epidemiological parameters related to Zika virus during the COVID-19 pandemic and the progress made since 2020 in various aspects of infection. A narrative review was conducted, focusing on articles published between January 2020 and June 2023, covering epidemiology, pathogenicity, transmission, diagnosis, and treatment of Zika virus. The findings of this survey reveal that there has been a significant decrease in reported cases of Zika virus infection during the COVID-19 pandemic, however, advancements have been made in understanding the pathogenicity of the virus and the development of new diagnostic methods, vaccines, and treatments. The lessons learned from the response to COVID-19 have played a pivotal role in guiding efforts that have resulted in progress regarding various aspects related to Zika virus infection.展开更多
基金funded by the National Natural Science Foundation of China(31871928,31671993)the Guangdong Special Branch Plan for Young Talent with Scientific and Technological Innovation(2019TQ05N158)+2 种基金the Pearl River S&T Nova Program of Guangzhou(201906010093)the Research and Development Project in Major Fields of Guangdong(2019B020238001)the Guangdong Provincial Innovation Team for General Key Technologies in Modern Agricultural Industry(2019KJ133).
文摘Arthropod-borne viruses cause serious threats to human health and global agriculture by rapidly spreading via insect vectors. Southern rice black-streaked dwarf virus (SRBSDV) is the most damaging rice-infecting virus that is frequently transmitted by planthoppers. However, the molecular mechanisms underlying its propagation in the host plants and epidemics in the field are largely unknown. Here, we showed that the SRBSDV-encoded P6 protein is a key effector that regulates rice ethylene signaling to coordinate viral infection and transmission. In early SRBSDV infection, P6 interacts with OsRTH2 in the cytoplasm to activate ethylene signaling and enhance SRBSDV proliferation;this also repels the insect vector to reduce infestation. In late infection, P6 enters the nucleus, where it interacts with OsEIL2, a key transcription factor of ethylene signaling. The P6-OsEIL2 interaction suppresses ethylene signaling by preventing the dimerization of OsEIL2, thereby facilitating viral transmission by attracting the insect vector. Collectively, these findings reveal a novel molecular mechanism by which an arbovirus modulates the host defense system to promote viral infection and transmission.
文摘The COVID-19 pandemic has changed the focus of authorities and health organizations with respect to other infectious diseases. This review aims to examine the changes in global epidemiological parameters related to Zika virus during the COVID-19 pandemic and the progress made since 2020 in various aspects of infection. A narrative review was conducted, focusing on articles published between January 2020 and June 2023, covering epidemiology, pathogenicity, transmission, diagnosis, and treatment of Zika virus. The findings of this survey reveal that there has been a significant decrease in reported cases of Zika virus infection during the COVID-19 pandemic, however, advancements have been made in understanding the pathogenicity of the virus and the development of new diagnostic methods, vaccines, and treatments. The lessons learned from the response to COVID-19 have played a pivotal role in guiding efforts that have resulted in progress regarding various aspects related to Zika virus infection.
