Atherosclerosis is the most important contributor to increasing burden of coronary artery disease (CAD). Growing evidence suggests that the ratios of Apo B/Apo A-I and Lp(a) are better indexes for risk assessment of C...Atherosclerosis is the most important contributor to increasing burden of coronary artery disease (CAD). Growing evidence suggests that the ratios of Apo B/Apo A-I and Lp(a) are better indexes for risk assessment of CAD. Elevated plasma levels of lipoprotein(a) in humans represent a major in-herited risk factor for atherosclerosis. Thus, a study was performed to determine the association betwwen serum Apo B, Apo A-I, and lipoprotein(a) levels, and severity of CAD in patients with CAD confirmed on coronary angiography findings. An analytical case control study was carried out with 85 patients (58 males and 27 females) 40 - 60 years of age confirmed as having CAD on coronary angiography and 85 age and sex matched healthy volunteers as controls. Serum samples were an-alyzed for Apo A-1 LDL, Apo B, Apo A-I, and lipoprotein(a) concentration and the severity of CAD was assessed using coronary angiography scoring method. Patients with CAD had significantly high serum LDL-C, Apo B and Lp(a) levels compared to control subjects. However, serum Apo A-I level did not show a significant difference between two groups. Subjects with a positive family history of CAD with increased serum Lp(a) ≥ 17.3 mg/dL have high risk for development of CAD. Present study suggests that serum Lp(a) cut-off value of 17.3 mg/dL may be an important predictor in ruling out major vessel disease and luminal narrowing by atheroma.展开更多
The differences of serum lipid and lipoprotein (LP,profiles of animals susceptible (rabbit)and nonsusceptible (Beijing duck) to atherosclerosis as well as the distribution of apolipo-protein (apo) A-I and its cataboli...The differences of serum lipid and lipoprotein (LP,profiles of animals susceptible (rabbit)and nonsusceptible (Beijing duck) to atherosclerosis as well as the distribution of apolipo-protein (apo) A-I and its catabolism in vivo were studied.Eight items,i.e.total cholesterol(TC),high density lipoprotein (HDL) cholesterol,triglyceride,percentage of a-LP and β-LP,β-LP concentration,lecithin cholesterol acyl transferase (LCAT),and agarose and polyacryla-mide gel electrophoresis of both species were assayed before and after feeding a high fat,high cholesterol diet.Results indicate that the exogenous cholesterol consumed by Beijingducks was carried and transported by HDL,while that in rabbits was transported by lowdensity lipoprotein (LDL).The biological half lives of apo A-I in serum and in HDL were41.11±2.4 and 42.8±1.7 h respectively.and its distribution in different organs was in theorder of liver】kidney】spleen】lung】heart】intestine】muscles】aorta.These resultsshow that the liver is the major organ for metabolizing HDL apo A-I.and the kidneyis also important.The results also imply that in Beijing ducks the cholesterol carried byHDL may be catabolized through apo A-I receptors in the liver and kidney.The differencesin cholesterol binding and in lipoprotein and apolipoprotein metabolism of the two speciesprovide important clues for the elucidation of the pathogenesis of atherosclerosis.展开更多
文摘Atherosclerosis is the most important contributor to increasing burden of coronary artery disease (CAD). Growing evidence suggests that the ratios of Apo B/Apo A-I and Lp(a) are better indexes for risk assessment of CAD. Elevated plasma levels of lipoprotein(a) in humans represent a major in-herited risk factor for atherosclerosis. Thus, a study was performed to determine the association betwwen serum Apo B, Apo A-I, and lipoprotein(a) levels, and severity of CAD in patients with CAD confirmed on coronary angiography findings. An analytical case control study was carried out with 85 patients (58 males and 27 females) 40 - 60 years of age confirmed as having CAD on coronary angiography and 85 age and sex matched healthy volunteers as controls. Serum samples were an-alyzed for Apo A-1 LDL, Apo B, Apo A-I, and lipoprotein(a) concentration and the severity of CAD was assessed using coronary angiography scoring method. Patients with CAD had significantly high serum LDL-C, Apo B and Lp(a) levels compared to control subjects. However, serum Apo A-I level did not show a significant difference between two groups. Subjects with a positive family history of CAD with increased serum Lp(a) ≥ 17.3 mg/dL have high risk for development of CAD. Present study suggests that serum Lp(a) cut-off value of 17.3 mg/dL may be an important predictor in ruling out major vessel disease and luminal narrowing by atheroma.
基金This investigation was supported by grants from the National Committee of Science and Technology and from the Chinese Ministry of Public Healthand was reported in the International Symposium on Cardiovascular Medicine and Surgery.1987,Beijing.
文摘The differences of serum lipid and lipoprotein (LP,profiles of animals susceptible (rabbit)and nonsusceptible (Beijing duck) to atherosclerosis as well as the distribution of apolipo-protein (apo) A-I and its catabolism in vivo were studied.Eight items,i.e.total cholesterol(TC),high density lipoprotein (HDL) cholesterol,triglyceride,percentage of a-LP and β-LP,β-LP concentration,lecithin cholesterol acyl transferase (LCAT),and agarose and polyacryla-mide gel electrophoresis of both species were assayed before and after feeding a high fat,high cholesterol diet.Results indicate that the exogenous cholesterol consumed by Beijingducks was carried and transported by HDL,while that in rabbits was transported by lowdensity lipoprotein (LDL).The biological half lives of apo A-I in serum and in HDL were41.11±2.4 and 42.8±1.7 h respectively.and its distribution in different organs was in theorder of liver】kidney】spleen】lung】heart】intestine】muscles】aorta.These resultsshow that the liver is the major organ for metabolizing HDL apo A-I.and the kidneyis also important.The results also imply that in Beijing ducks the cholesterol carried byHDL may be catabolized through apo A-I receptors in the liver and kidney.The differencesin cholesterol binding and in lipoprotein and apolipoprotein metabolism of the two speciesprovide important clues for the elucidation of the pathogenesis of atherosclerosis.
