流行状况过敏性鼻炎,也称变应性鼻炎,是特应性个体接触过敏原后由Ig E介导的鼻黏膜炎症反应性疾病,其主要症状是反复喷嚏、清涕、鼻塞和鼻痒,患者常伴眼痒、结膜充血和/或流泪。根据2008年版'过敏性鼻炎及其对哮喘的影响'(aller...流行状况过敏性鼻炎,也称变应性鼻炎,是特应性个体接触过敏原后由Ig E介导的鼻黏膜炎症反应性疾病,其主要症状是反复喷嚏、清涕、鼻塞和鼻痒,患者常伴眼痒、结膜充血和/或流泪。根据2008年版'过敏性鼻炎及其对哮喘的影响'(allergic rhinitis and its impact on asthma,ARIA)数据显示,全球约有6亿人患有过敏性鼻炎且呈流行增加的趋势,它不仅影响患者的日常生活、睡眠、工作和学习,展开更多
Background Recent recognition is that Th2 response is insufficient to fully explain the aetiology of asthma. Other CD4^＋ T cells subsets might play a role in asthma. We investigated the relative abundance and activit...Background Recent recognition is that Th2 response is insufficient to fully explain the aetiology of asthma. Other CD4^＋ T cells subsets might play a role in asthma. We investigated the relative abundance and activities of Thl, Th2, Th17 and CD4^＋CD25^＋ Treg cells in patients with allergic asthma. Methods Twenty-two patients with mild asthma, 17 patients with moderate to severe asthma and 20 healthy donors were enrolled. All patients were allergic to house dust mites. Plasma total IgE, pulmonary function and Asthma Control Questionnaire were assessed. The proportions of peripheral blood Thl, Th2, Th17 and CD4^＋CD25^＋ Treg cells were determined by flow cytometry. The expression of cytokines in plasma and Jn the culture supernatant of peripheral blood mononuclear cells was determined by enzyme linked, immunosorbent assay. Results The frequency of blood Th2 cells and IL-4 levels in plasma and culture supernatant of peripheral blood mononuclear cells were increased in all patients with allergic asthma. The frequency of Th17 cells and the plasma and culture supernatant levels of IL-17 were increased, whereas the frequency of CD4^＋CD25^＋ Treg cells and plasma IL-10 levels were decreased in patients with moderate to severe asthma. Dermatophagoides pteronyssinus specific IgE levels were positively correlated with the percentage of blood Th2 cells and plasma IL-4 levels. Forced expiratory volume in the first second was negatively correlated with the frequency of Th17 cells and plasma IL-17 levels, and positively correlated with the frequency of Treg cells. However, mean Asthma Control Questionnaire scores were positively correlated with the frequency of Th17 cells and plasma IL-17 levels, and negatively correlated with the frequency of Treg cells. Conclusions Imbalances in Thl/Th2 and Th17/Treg were found in patients with allergic asthma. Furthermore, elevated Th17 cell responses, the absence of Tregs and an imbalance in Th17/Treg levels were associated with moderate to severe asthma.展开更多
目的:通过Meta分析,了解中国变应性鼻炎(AR)的患病率及探讨国内人群AR的主要危险因素,为AR的防治提供科学依据。方法:系统检索Pubmed、Embase、Web of science、Cochrane图书馆、中国期刊全文数据库、中文科技期刊全文数据库、万方数字...目的:通过Meta分析,了解中国变应性鼻炎(AR)的患病率及探讨国内人群AR的主要危险因素,为AR的防治提供科学依据。方法:系统检索Pubmed、Embase、Web of science、Cochrane图书馆、中国期刊全文数据库、中文科技期刊全文数据库、万方数字化期刊全文数据库、中国生物医学文献数据库等数据库查找关于中国AR患病率及危险因素相关文献,同时追索纳入文献的参考文献。采用R3.2.3软件对各研究结果进行Meta分析。结果:共纳入31篇文献,国内儿童AR患病率为15.79%(95%CI 15.13~16.45),华中地区患病率最高(17.20%),华东最低(13.94%)。成人AR患病率为13.26%(95%CI 12.05~14.47),华南地区患病率最高(15.45%),西南最低(10.93%)。各危险因素合并比值比(OR)分别为家族史(5.40)、粉尘接触史(2.04)、药物过敏史(2.83)、哮喘病史(4.45)、环境烟草烟雾(2.00)、水泛滥(1.50)、装修(1.41)、花粉过敏(17.18)、真菌(1.31)、饲养宠物(1.29)、蟑螂(1.69)。结论:中国AR的流行趋势研究发现,国内儿童AR患病率高于成人,不同地区患病率有差异,上述11种危险因素在AR的发病中起重要作用,在AR的防治过程中应针对这些危险因素进行早期干预。展开更多
Helicobacter pylori(H. pylori) infection is very common and affects approximately half of the world population. It causes gastric diseases, but some authors have reported an association of H. pylori infection with oth...Helicobacter pylori(H. pylori) infection is very common and affects approximately half of the world population. It causes gastric diseases, but some authors have reported an association of H. pylori infection with other systemic manifestations beginning in 1994. The list of potential effects of H. pylori outside the stomach includes a number of extragastric manifestations and we focused on neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic, and hepatobiliary diseases. This review discusses these important reported manifestations that are not related to the gastrointestinal tract.展开更多
文摘流行状况过敏性鼻炎,也称变应性鼻炎,是特应性个体接触过敏原后由Ig E介导的鼻黏膜炎症反应性疾病,其主要症状是反复喷嚏、清涕、鼻塞和鼻痒,患者常伴眼痒、结膜充血和/或流泪。根据2008年版'过敏性鼻炎及其对哮喘的影响'(allergic rhinitis and its impact on asthma,ARIA)数据显示,全球约有6亿人患有过敏性鼻炎且呈流行增加的趋势,它不仅影响患者的日常生活、睡眠、工作和学习,
文摘Background Recent recognition is that Th2 response is insufficient to fully explain the aetiology of asthma. Other CD4^＋ T cells subsets might play a role in asthma. We investigated the relative abundance and activities of Thl, Th2, Th17 and CD4^＋CD25^＋ Treg cells in patients with allergic asthma. Methods Twenty-two patients with mild asthma, 17 patients with moderate to severe asthma and 20 healthy donors were enrolled. All patients were allergic to house dust mites. Plasma total IgE, pulmonary function and Asthma Control Questionnaire were assessed. The proportions of peripheral blood Thl, Th2, Th17 and CD4^＋CD25^＋ Treg cells were determined by flow cytometry. The expression of cytokines in plasma and Jn the culture supernatant of peripheral blood mononuclear cells was determined by enzyme linked, immunosorbent assay. Results The frequency of blood Th2 cells and IL-4 levels in plasma and culture supernatant of peripheral blood mononuclear cells were increased in all patients with allergic asthma. The frequency of Th17 cells and the plasma and culture supernatant levels of IL-17 were increased, whereas the frequency of CD4^＋CD25^＋ Treg cells and plasma IL-10 levels were decreased in patients with moderate to severe asthma. Dermatophagoides pteronyssinus specific IgE levels were positively correlated with the percentage of blood Th2 cells and plasma IL-4 levels. Forced expiratory volume in the first second was negatively correlated with the frequency of Th17 cells and plasma IL-17 levels, and positively correlated with the frequency of Treg cells. However, mean Asthma Control Questionnaire scores were positively correlated with the frequency of Th17 cells and plasma IL-17 levels, and negatively correlated with the frequency of Treg cells. Conclusions Imbalances in Thl/Th2 and Th17/Treg were found in patients with allergic asthma. Furthermore, elevated Th17 cell responses, the absence of Tregs and an imbalance in Th17/Treg levels were associated with moderate to severe asthma.
文摘目的:通过Meta分析,了解中国变应性鼻炎(AR)的患病率及探讨国内人群AR的主要危险因素,为AR的防治提供科学依据。方法:系统检索Pubmed、Embase、Web of science、Cochrane图书馆、中国期刊全文数据库、中文科技期刊全文数据库、万方数字化期刊全文数据库、中国生物医学文献数据库等数据库查找关于中国AR患病率及危险因素相关文献,同时追索纳入文献的参考文献。采用R3.2.3软件对各研究结果进行Meta分析。结果:共纳入31篇文献,国内儿童AR患病率为15.79%(95%CI 15.13~16.45),华中地区患病率最高(17.20%),华东最低(13.94%)。成人AR患病率为13.26%(95%CI 12.05~14.47),华南地区患病率最高(15.45%),西南最低(10.93%)。各危险因素合并比值比(OR)分别为家族史(5.40)、粉尘接触史(2.04)、药物过敏史(2.83)、哮喘病史(4.45)、环境烟草烟雾(2.00)、水泛滥(1.50)、装修(1.41)、花粉过敏(17.18)、真菌(1.31)、饲养宠物(1.29)、蟑螂(1.69)。结论:中国AR的流行趋势研究发现,国内儿童AR患病率高于成人,不同地区患病率有差异,上述11种危险因素在AR的发病中起重要作用,在AR的防治过程中应针对这些危险因素进行早期干预。
文摘Helicobacter pylori(H. pylori) infection is very common and affects approximately half of the world population. It causes gastric diseases, but some authors have reported an association of H. pylori infection with other systemic manifestations beginning in 1994. The list of potential effects of H. pylori outside the stomach includes a number of extragastric manifestations and we focused on neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic, and hepatobiliary diseases. This review discusses these important reported manifestations that are not related to the gastrointestinal tract.
