Increased posterior tibial slope (PTS), medial tibial plateau slope (MTPS) and lateral tibial plateau slope (LTPS) have been proposed as potential risk factors for anterior cruciate ligament (ACL) tear. However, prior...Increased posterior tibial slope (PTS), medial tibial plateau slope (MTPS) and lateral tibial plateau slope (LTPS) have been proposed as potential risk factors for anterior cruciate ligament (ACL) tear. However, prior literature is inconclusive. The primary goal of the study was to investigate the relationship of MTPS, LTPS and PTS with ACL tears. The secondary goal was to determine whether injury mechanisms, age, gender, tobacco, obesity, extreme PTS (>12<span style="font-family:;" "=""><span style="font-family:Verdana;"><span style="color:#111111;font-family:Roboto, sans-serif;font-size:16px;white-space:normal;background-color:#FFFFFF;">°</span></span><span style="font-family:Verdana;">) or previous injuries are risk factors in ACL tears. Three groups were identified: a study group of patients with ACL injury;a second group diagnosed with meniscal injury;and a third group of non-injured patients. Demographic data was collected</span></span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> MTPS and LTPS were measured in MRI and PTS in lateral radiographs by two blinded observers. Data was analyzed using SPSS. 416 patients were included in the study. MTPS ranged from 0</span><span style="font-family:;" "=""><span style="font-family:Verdana;"><span style="color:#111111;font-family:Roboto, sans-serif;font-size:16px;white-space:normal;background-color:#FFFFFF;">°</span></span><span style="font-family:Verdana;"> to 14</span><span style="font-family:Verdana;"><span style="color:#111111;font-family:Roboto, sans-serif;font-size:16px;white-space:normal;background-color:#FFFFFF;">°</span></span><span style="font-family:Verdana;"> (average value 5.66 ± 2.98), LTSA 0</span><span style="font-family:Verdana;"><span style="color:#111111;font-family:Roboto, sans-serif;font-size:16px;white-space:normal;background-color:#FFFFFF;">°</span></span><span style="font-family:Verdana;"> to 16</span><span style="font-family:Verdana;"><span style="color:#111111;font-family:Roboto, sans-serif;font-size:16p展开更多
目的 利用Meta分析方法对COL12A1?rs970547位点基因多态性与前交叉韧带(anterior cruciate ligament,ACL)损伤相关性进行系统评价.方法 对2018年3月之前发表的关于COL12A1?rs970547位点基因与ACL损伤的文献进行检索、收集和整理,用Meta...目的 利用Meta分析方法对COL12A1?rs970547位点基因多态性与前交叉韧带(anterior cruciate ligament,ACL)损伤相关性进行系统评价.方法 对2018年3月之前发表的关于COL12A1?rs970547位点基因与ACL损伤的文献进行检索、收集和整理,用Meta分析的方法分析等位基因G vs A、显性模型(AG+GG)vs AA、隐性模型GG vs(AA+AG)、共显性模型AA vs GG和AA vs GA在ACL损伤组与对照组中是否有差异,以期深入揭示COL12A1?rs970547位点基因多态性与ACL损伤的联系.结果 本研究在5个团队的5份独立样本(包括患者686例和健康对照890例)的Meta分析发现,总体人群中,COL12A1?rs970547位点基因多态性与ACL损伤在等位基因G vs A[OR=1.29,95% CI (1.05,1.60),P=0. 02]、显性模型(AG+GG)vs AA[OR=1.49,95% CI(1.17,1.89),P=0. 001]、共显性模型AA vs GA[OR=1.57,95% CI(1.23,2.01),P=0. 0003]方面差异有统计学意义,可认为COL12A1?rs970547位点基因多态性与ACL损伤存在一定的关联性.单独对欧洲?高加索人种、亚洲人种进行亚组Meta分析,结果显示欧洲?高加索人种中,等位基因G vs A、各基因模型在ACL损伤组与对照组中的差别无统计学意义(P>0. 05),尚不能认为欧洲?高加索人种中COL12A1?rs970547位点基因多态性与ACL损伤存在关联性.在亚洲人种中等位基因G vs A[OR=1.76,95% CI(1.20,2.57),P=0.004]、显性模型(AG+GG)vs AA[OR=2.93,95% CI(1.58,5.44),P=0. 0007]、共显性模型AA vs GG[OR=3.92, 95% CI(1.46,10.47),P=0.000 7]和AA vs GA[OR=2.83,95% CI(1.50,5.34),P=0. 001]在ACL损伤组与对照组中的差异有统计学意义,可认为亚洲人种中COL12A1?rs970547位点基因多态性与ACL损伤存在关联性.结论 本次Meta分析显示至少在亚洲人种中,COL12A1?rs970547位点基因多态性与ACL损伤存在关联性,利用这种基因有助于发现ACL损伤新的预防及治疗策略.展开更多
文摘Increased posterior tibial slope (PTS), medial tibial plateau slope (MTPS) and lateral tibial plateau slope (LTPS) have been proposed as potential risk factors for anterior cruciate ligament (ACL) tear. However, prior literature is inconclusive. The primary goal of the study was to investigate the relationship of MTPS, LTPS and PTS with ACL tears. The secondary goal was to determine whether injury mechanisms, age, gender, tobacco, obesity, extreme PTS (>12<span style="font-family:;" "=""><span style="font-family:Verdana;"><span style="color:#111111;font-family:Roboto, sans-serif;font-size:16px;white-space:normal;background-color:#FFFFFF;">°</span></span><span style="font-family:Verdana;">) or previous injuries are risk factors in ACL tears. Three groups were identified: a study group of patients with ACL injury;a second group diagnosed with meniscal injury;and a third group of non-injured patients. Demographic data was collected</span></span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> MTPS and LTPS were measured in MRI and PTS in lateral radiographs by two blinded observers. Data was analyzed using SPSS. 416 patients were included in the study. MTPS ranged from 0</span><span style="font-family:;" "=""><span style="font-family:Verdana;"><span style="color:#111111;font-family:Roboto, sans-serif;font-size:16px;white-space:normal;background-color:#FFFFFF;">°</span></span><span style="font-family:Verdana;"> to 14</span><span style="font-family:Verdana;"><span style="color:#111111;font-family:Roboto, sans-serif;font-size:16px;white-space:normal;background-color:#FFFFFF;">°</span></span><span style="font-family:Verdana;"> (average value 5.66 ± 2.98), LTSA 0</span><span style="font-family:Verdana;"><span style="color:#111111;font-family:Roboto, sans-serif;font-size:16px;white-space:normal;background-color:#FFFFFF;">°</span></span><span style="font-family:Verdana;"> to 16</span><span style="font-family:Verdana;"><span style="color:#111111;font-family:Roboto, sans-serif;font-size:16p
基金2016年长治医学院科技启动基金项目(普及项目)(QDZ201656)山西省晋城市科技计划(201702019)Fund Program:Science and technology startup fund project of Changzhi Medical College(popularization project)(201661)Science and technology fund project of Jincheng in Shanxi Province(201702019).
文摘目的 利用Meta分析方法对COL12A1?rs970547位点基因多态性与前交叉韧带(anterior cruciate ligament,ACL)损伤相关性进行系统评价.方法 对2018年3月之前发表的关于COL12A1?rs970547位点基因与ACL损伤的文献进行检索、收集和整理,用Meta分析的方法分析等位基因G vs A、显性模型(AG+GG)vs AA、隐性模型GG vs(AA+AG)、共显性模型AA vs GG和AA vs GA在ACL损伤组与对照组中是否有差异,以期深入揭示COL12A1?rs970547位点基因多态性与ACL损伤的联系.结果 本研究在5个团队的5份独立样本(包括患者686例和健康对照890例)的Meta分析发现,总体人群中,COL12A1?rs970547位点基因多态性与ACL损伤在等位基因G vs A[OR=1.29,95% CI (1.05,1.60),P=0. 02]、显性模型(AG+GG)vs AA[OR=1.49,95% CI(1.17,1.89),P=0. 001]、共显性模型AA vs GA[OR=1.57,95% CI(1.23,2.01),P=0. 0003]方面差异有统计学意义,可认为COL12A1?rs970547位点基因多态性与ACL损伤存在一定的关联性.单独对欧洲?高加索人种、亚洲人种进行亚组Meta分析,结果显示欧洲?高加索人种中,等位基因G vs A、各基因模型在ACL损伤组与对照组中的差别无统计学意义(P>0. 05),尚不能认为欧洲?高加索人种中COL12A1?rs970547位点基因多态性与ACL损伤存在关联性.在亚洲人种中等位基因G vs A[OR=1.76,95% CI(1.20,2.57),P=0.004]、显性模型(AG+GG)vs AA[OR=2.93,95% CI(1.58,5.44),P=0. 0007]、共显性模型AA vs GG[OR=3.92, 95% CI(1.46,10.47),P=0.000 7]和AA vs GA[OR=2.83,95% CI(1.50,5.34),P=0. 001]在ACL损伤组与对照组中的差异有统计学意义,可认为亚洲人种中COL12A1?rs970547位点基因多态性与ACL损伤存在关联性.结论 本次Meta分析显示至少在亚洲人种中,COL12A1?rs970547位点基因多态性与ACL损伤存在关联性,利用这种基因有助于发现ACL损伤新的预防及治疗策略.
