Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diket...Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diketone（3） were isolated from the whole herbs of Selaginella involven Spring.The structures were elucidated by spectroscopic analyses including UV,IR,1D,2D NMR and MS methods.Additionally,these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.展开更多
A new diterpenoid was isolated from the ethanolic extract of the dried root bark of Tripterygium wilfordii Hook.f. It is the first example of abietane diterpenoid glycoside isolated from Tripterygium wilfordii Hook.f...A new diterpenoid was isolated from the ethanolic extract of the dried root bark of Tripterygium wilfordii Hook.f. It is the first example of abietane diterpenoid glycoside isolated from Tripterygium wilfordii Hook.f. Its structure was identified to be 11-O-b-D-glucopyranosyl- neotriptophenolide based on spectral methods.展开更多
A new diterpene with an abietane skeleton, 3β-hydroxy-8α,14α-epoxyabieta-11,13(15)- dien-16,12-olide, was isolated from the root of Suregada glomerulate(Blume) Baill. Its structure was elucidated on the basis of sp...A new diterpene with an abietane skeleton, 3β-hydroxy-8α,14α-epoxyabieta-11,13(15)- dien-16,12-olide, was isolated from the root of Suregada glomerulate(Blume) Baill. Its structure was elucidated on the basis of spectroscopic and X-ray crystallographic analysis.展开更多
Two dimeric abietane diterpenoids,salviwardins A and B(1 and 2),and a seco-abietane diterpenoid salviwardin C(3),along with five known analogues(4–8),were isolated from the roots of Salvia wardii.The structures of t...Two dimeric abietane diterpenoids,salviwardins A and B(1 and 2),and a seco-abietane diterpenoid salviwardin C(3),along with five known analogues(4–8),were isolated from the roots of Salvia wardii.The structures of these isolates were elucidated by extensive spectroscopic methods.The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.展开更多
Six new abietane diterpenoids(1−6)and five undescribed iridoids(7−11)have been isolated from the aerial parts of Caryopteris mongolica.The intricate structural characterization of these compounds was meticulously unde...Six new abietane diterpenoids(1−6)and five undescribed iridoids(7−11)have been isolated from the aerial parts of Caryopteris mongolica.The intricate structural characterization of these compounds was meticulously undertaken using an array of advanced spectroscopic techniques.This process was further enhanced by the application of DP4+probability analyses and electronic circular dichroism(ECD)calculations.Following isolation and structural elucidation,the cytotoxicity of these compounds was evaluated.Among them,compound 3 stood out,displaying significant cytotoxic activity against HeLa cells with an IC50 value of 7.83±1.28μmol·L^(−1).Additionally,compounds 1,2,4,9,and 10 manifested moderate cytotoxic effects on specific cell lines,with IC50 values ranging from 11.7 to 20.9μmol·L^(−1).展开更多
The structures of two new abietane quinones, named micranthins A and B, were determined to be 7a-methoxy-14, 16-epoxy-8, 13-abietadiene-11, 12-dione (1) and 16-acetoxy-6, 7-dehydroroyleanone (2) respectively, which we...The structures of two new abietane quinones, named micranthins A and B, were determined to be 7a-methoxy-14, 16-epoxy-8, 13-abietadiene-11, 12-dione (1) and 16-acetoxy-6, 7-dehydroroyleanone (2) respectively, which were isolated from Isodon lophanthoides var. micranthus.展开更多
The structure of a new abietane diterpenoid, taxayunnin (1), from the barks of Taxus yunnanensis, was determined by spectroscopic analysis. A known abietane diterpenoid, taxamairin C (2), was also isolated.
A new abietane quinone diterpenoid was isolated, together with horminone, 16-acetoxy-7-O-acetylhorminone, beta-sitosterol, stigmasterol. ursolic acid and palmitic acid from the leaves of Rabdosin Serra (MAXIM) Hara. T...A new abietane quinone diterpenoid was isolated, together with horminone, 16-acetoxy-7-O-acetylhorminone, beta-sitosterol, stigmasterol. ursolic acid and palmitic acid from the leaves of Rabdosin Serra (MAXIM) Hara. The new compound was elucidated as 16-acetoxy-7 alpha-ethoxyroyleanone.展开更多
Three new abietane diterpene lactones, 3-hydroxyjolkinolide A (1), ent-8,14-dihydroxy-13(15)-ene-16(12)- abietanolide (2) and ent-8,14-dihydroxy-13(15)-ene-16(12)-abietanolide (3) as well as a known abietane diter-pen...Three new abietane diterpene lactones, 3-hydroxyjolkinolide A (1), ent-8,14-dihydroxy-13(15)-ene-16(12)- abietanolide (2) and ent-8,14-dihydroxy-13(15)-ene-16(12)-abietanolide (3) as well as a known abietane diter-pene jolkinolide A (4) were isolated from the roots of Euphorbia wallichii. Their structures were elucidated on the basis of spectroscopic analysis.展开更多
A new abietane diterpenoid, orthosiphonol (11-methoxy-12, 14-dihydroxy-8, 11, 13-abieta trien-7-one) (1) together with known 11-hydroxysugiol (2) were isolated from Orthosiphon wulfenioides. Their structures were det...A new abietane diterpenoid, orthosiphonol (11-methoxy-12, 14-dihydroxy-8, 11, 13-abieta trien-7-one) (1) together with known 11-hydroxysugiol (2) were isolated from Orthosiphon wulfenioides. Their structures were determined on the basis of spectroscopic evidence.展开更多
Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distich...Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distichum cones and their biological properties evaluated in vitro against six different biological screening targets. Taxodione showed potent activity against a number of different targets, and salvinolone and 14-deoxycoleon U showed remarkable inhibitory activities against prolyl oligopeptidase (POP) and 17α-hydroxylase/C17,20-lyase (CYP17), respectively. These three compounds also showed strong cytotoxic activities against HL60 and K562 human leukemia cells. The structure-activity relationships of these compounds have also been considered. The findings in this study could lead to enhanced pharmacological prospects for the natural abietane-type diterpenoids consisting in conifer cones.展开更多
A new ent-abietane diterpernoid,named ebracteolata D(1),along with 11 known analogues,was isolated from the roots of Euphorbia ebracteolata Hayata.The structure of 1 was elucidated on the basis of spectroscopic analys...A new ent-abietane diterpernoid,named ebracteolata D(1),along with 11 known analogues,was isolated from the roots of Euphorbia ebracteolata Hayata.The structure of 1 was elucidated on the basis of spectroscopic analysis and molecular modeling.Cytotoxicity of compounds 1-12 was evaluated as well as the effect on the NF-κB pathway.Among them,compound 12,jolkinolide B,displayed broad inhibitory effects against proliferation of tumor cell lines.Mechanistic studies indicated that the compound 12 can inhibit TNF-αinduced NF-κB activation,thereby inducing tumor cell apoptosis.展开更多
Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4,a versatile intermediate 6 was found.The com...Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4,a versatile intermediate 6 was found.The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees in selected abietane diterpenes when synthesized through high yield Suzuki reaction and subsequent cyclization,and total synthesis of 1-oxomiltirone(1)has been achieved.展开更多
基金supported by National Natural Science Foundation (No. 31370370)the Doctoral Program Foundation of Institutions of Higher Education of China (No. 20100162110057)Chinese Medicine Research Program of Hunan Province (Nos. 2009059 and 2010004)
文摘Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diketone（3） were isolated from the whole herbs of Selaginella involven Spring.The structures were elucidated by spectroscopic analyses including UV,IR,1D,2D NMR and MS methods.Additionally,these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.
文摘A new diterpenoid was isolated from the ethanolic extract of the dried root bark of Tripterygium wilfordii Hook.f. It is the first example of abietane diterpenoid glycoside isolated from Tripterygium wilfordii Hook.f. Its structure was identified to be 11-O-b-D-glucopyranosyl- neotriptophenolide based on spectral methods.
基金the Natural Science Foundation of Beijing(No.2042020)for support of this research
文摘A new diterpene with an abietane skeleton, 3β-hydroxy-8α,14α-epoxyabieta-11,13(15)- dien-16,12-olide, was isolated from the root of Suregada glomerulate(Blume) Baill. Its structure was elucidated on the basis of spectroscopic and X-ray crystallographic analysis.
基金the foundations from NSFC(81373291)the National Science and Technology Support Program of China(2013BAI11B02)the Young Academic Leader Raising Foundation of Yunnan Province(No.2009CI073)。
文摘Two dimeric abietane diterpenoids,salviwardins A and B(1 and 2),and a seco-abietane diterpenoid salviwardin C(3),along with five known analogues(4–8),were isolated from the roots of Salvia wardii.The structures of these isolates were elucidated by extensive spectroscopic methods.The inhibitory activities of these isolates against five human cancer cell lines in vitro were also tested.
基金This work was supported by the National Nature Science Foundation of China(No.21672152).
文摘Six new abietane diterpenoids(1−6)and five undescribed iridoids(7−11)have been isolated from the aerial parts of Caryopteris mongolica.The intricate structural characterization of these compounds was meticulously undertaken using an array of advanced spectroscopic techniques.This process was further enhanced by the application of DP4+probability analyses and electronic circular dichroism(ECD)calculations.Following isolation and structural elucidation,the cytotoxicity of these compounds was evaluated.Among them,compound 3 stood out,displaying significant cytotoxic activity against HeLa cells with an IC50 value of 7.83±1.28μmol·L^(−1).Additionally,compounds 1,2,4,9,and 10 manifested moderate cytotoxic effects on specific cell lines,with IC50 values ranging from 11.7 to 20.9μmol·L^(−1).
文摘The structures of two new abietane quinones, named micranthins A and B, were determined to be 7a-methoxy-14, 16-epoxy-8, 13-abietadiene-11, 12-dione (1) and 16-acetoxy-6, 7-dehydroroyleanone (2) respectively, which were isolated from Isodon lophanthoides var. micranthus.
基金This project was supported by the National Natural Science Foundation of China (3950081)theYoung Academic and Technical Leader Raising Foundation of Yunnan Province (awarded to H.-J.Zhang.) the Special Supported Bioscience and Biotechnique Foundation of Academic Sinica(STZ-11).
文摘The structure of a new abietane diterpenoid, taxayunnin (1), from the barks of Taxus yunnanensis, was determined by spectroscopic analysis. A known abietane diterpenoid, taxamairin C (2), was also isolated.
文摘A new abietane quinone diterpenoid was isolated, together with horminone, 16-acetoxy-7-O-acetylhorminone, beta-sitosterol, stigmasterol. ursolic acid and palmitic acid from the leaves of Rabdosin Serra (MAXIM) Hara. The new compound was elucidated as 16-acetoxy-7 alpha-ethoxyroyleanone.
基金Project supported by the Foundation of the State Key Laboratory of Phytochemistry and Plant Resources in west China Kunming Institute of Botany Chinese Academy of Sciences and Knowledge Innovation Project from the Northwest Institute of Plateau Biology
文摘Three new abietane diterpene lactones, 3-hydroxyjolkinolide A (1), ent-8,14-dihydroxy-13(15)-ene-16(12)- abietanolide (2) and ent-8,14-dihydroxy-13(15)-ene-16(12)-abietanolide (3) as well as a known abietane diter-pene jolkinolide A (4) were isolated from the roots of Euphorbia wallichii. Their structures were elucidated on the basis of spectroscopic analysis.
文摘A new abietane diterpenoid, orthosiphonol (11-methoxy-12, 14-dihydroxy-8, 11, 13-abieta trien-7-one) (1) together with known 11-hydroxysugiol (2) were isolated from Orthosiphon wulfenioides. Their structures were determined on the basis of spectroscopic evidence.
文摘Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distichum cones and their biological properties evaluated in vitro against six different biological screening targets. Taxodione showed potent activity against a number of different targets, and salvinolone and 14-deoxycoleon U showed remarkable inhibitory activities against prolyl oligopeptidase (POP) and 17α-hydroxylase/C17,20-lyase (CYP17), respectively. These three compounds also showed strong cytotoxic activities against HL60 and K562 human leukemia cells. The structure-activity relationships of these compounds have also been considered. The findings in this study could lead to enhanced pharmacological prospects for the natural abietane-type diterpenoids consisting in conifer cones.
基金supported financially by grants from the National Science Foundation of China(21432010,81573323,and 31770392)Technological Leading Talent Project of Yunnan Province(2015HA020)Central Asian Drug Discovery and Development Center of Chinese Academy of Sciences(CAM201402,CAM201302).
文摘A new ent-abietane diterpernoid,named ebracteolata D(1),along with 11 known analogues,was isolated from the roots of Euphorbia ebracteolata Hayata.The structure of 1 was elucidated on the basis of spectroscopic analysis and molecular modeling.Cytotoxicity of compounds 1-12 was evaluated as well as the effect on the NF-κB pathway.Among them,compound 12,jolkinolide B,displayed broad inhibitory effects against proliferation of tumor cell lines.Mechanistic studies indicated that the compound 12 can inhibit TNF-αinduced NF-κB activation,thereby inducing tumor cell apoptosis.
基金We would like to thank the Programs of“One Hundred Talented People”for its financial support.
文摘Abietane diterpenes and miltirone series have shown important activities and for medical purposes in order to achieve the total synthesis of 1-oxomiltrone 1 and miltirone 4,a versatile intermediate 6 was found.The compound 6 could be used as a precursor A-B-C rings with different oxidative degrees in selected abietane diterpenes when synthesized through high yield Suzuki reaction and subsequent cyclization,and total synthesis of 1-oxomiltirone(1)has been achieved.
