本研究选择5种多溴联苯醚同系物（BDE-28、BDE-47、BDE-99、BDE-153和BDE-209）对2种海洋饵料藻（亚心型扁藻和盐生杜氏藻）进行急性毒性试验。96 h半抑制浓度（96 h EC50）计算结果表明,BDE-28和BDE-47的毒性较高,随溴原子取代数的增加...本研究选择5种多溴联苯醚同系物（BDE-28、BDE-47、BDE-99、BDE-153和BDE-209）对2种海洋饵料藻（亚心型扁藻和盐生杜氏藻）进行急性毒性试验。96 h半抑制浓度（96 h EC50）计算结果表明,BDE-28和BDE-47的毒性较高,随溴原子取代数的增加,PBDE同系物对海洋饵料藻的毒性呈下降趋势,5种PBDE同系物对亚心形扁藻、盐生杜氏藻的96 h EC50由小及大依次为：BDE-28（128,75μg/L）、BDE-47（114,120μg/L）、BDE-99（383,572μg/L）、BDE-153（996,1249μg/L）和BDE-209（2056,1868μg/L）。目前全球近岸海水中PBDEs浓度尚不会对海洋饵料藻产生急性毒性。海洋微藻对同种PBDE同系物的敏感性差异较大（96 h EC50相差1~2个数量级）,为客观评价PBDEs的海洋生态风险性,应研究PBDEs对更多种类微藻的毒性效应。展开更多
Fungal diversity notes is one of the important journal series of fungal taxonomy that provide detailed descriptions and illustrations of new fungal taxa,as well as providing new information of fungal taxa worldwide.Th...Fungal diversity notes is one of the important journal series of fungal taxonomy that provide detailed descriptions and illustrations of new fungal taxa,as well as providing new information of fungal taxa worldwide.This article is the 11th contribution to the fungal diversity notes series,in which 126 taxa distributed in two phyla,six classes,24 orders and 55 families are described and illustrated.Taxa in this study were mainly collected from Italy by Erio Camporesi and also collected from China,India and Thailand,as well as in some other European,North American and South American countries.Taxa described in the present study include two new families,12 new genera,82 new species,five new combinations and 25 new records on new hosts and new geographical distributions as well as sexual-asexual reports.The two new families are Eriomycetaceae(Dothideomycetes,family incertae sedis)and Fasciatisporaceae(Xylariales,Sordariomycetes).The twelve new genera comprise Bhagirathimyces(Phaeosphaeriaceae),Camporesiomyces(Tubeufiaceae),Eriocamporesia(Cryphonectriaceae),Eriomyces(Eriomycetaceae),Neomonodictys(Pleurotheciaceae),Paraloratospora(Phaeosphaeriaceae),Paramonodictys(Parabambusicolaceae),Pseudoconlarium(Diaporthomycetidae,genus incertae sedis),Pseudomurilentithecium(Lentitheciaceae),Setoapiospora(Muyocopronaceae),Srinivasanomyces(Vibrisseaceae)and Xenoanthostomella(Xylariales,genera incertae sedis).The 82 new species comprise Acremonium chiangraiense,Adustochaete nivea,Angustimassarina camporesii,Bhagirathimyces himalayensis,Brunneoclavispora camporesii,Camarosporidiella camporesii,Camporesiomyces mali,Camposporium appendiculatum,Camposporium multiseptatum,Camposporium septatum,Canalisporium aquaticium,Clonostachys eriocamporesiana,Clonostachys eriocamporesii,Colletotrichum hederiicola,Coniochaeta vineae,Conioscypha verrucosa,Cortinarius ainsworthii,Cortinarius aurae,Cortinarius britannicus,Cortinarius heatherae,Cortinarius scoticus,Cortinarius subsaniosus,Cytospora fusispora,Cytospora rosigena,Diaporthe camporesii,Diapor展开更多
目的系统评价Rg3联合化疗治疗中晚期非小细胞肺癌的临床疗效及安全性。方法在CNKI、CBM、VIP、万方数据库、the Cochrane Central Register of Controlled Trials(CENTRAL)、Pub Med、EMbase、the ISI Web of Knowledge Databases数据...目的系统评价Rg3联合化疗治疗中晚期非小细胞肺癌的临床疗效及安全性。方法在CNKI、CBM、VIP、万方数据库、the Cochrane Central Register of Controlled Trials(CENTRAL)、Pub Med、EMbase、the ISI Web of Knowledge Databases数据库中检索相关研究,日期截至2015年3月。纳入Rg3联合化疗治疗非小细胞肺癌(Rg3联合化疗组)及单纯化疗(单纯化疗组)的随机对照试验,并用Rev Man 5.2统计软件进行Meta分析。结果纳入14项研究,包括833例晚期非小细胞肺癌患者。Meta分析结果显示:Rg3联合化疗组的疗效与单纯化疗组比较,差异有高度统计学意义(OR=1.72,95%CI=1.27~2.33,P=0.0005),且与单纯化疗组比较,Rg3联合化疗组中1年生存率(OR=2.12,95%CI=1.29~3.50,P=0.003)、KPS评分(OR=4.99,95%CI=2.87~8.65,P<0.0001)提高。两组血清VEGF水平(MD=-39.61,95%CI=-61.11^-18.11,P=0.0003)、白细胞减少(OR=0.36,95%CI=0.22~0.59,P<0.0001)、血小板减少(OR=0.27,95%CI=0.11~0.68,P=0.005)及胃肠道不良反应(OR=0.41,95%CI=0.21~0.81,P=0.01)差异均有高度统计学意义,但两组肝肾功能不良反应发生率(OR=0.62,95%CI=0.18~2.12,P=0.44)差异无统计学意义。结论在治疗晚期非小细胞肺癌疗效方面,Rg3与化疗方案联合优于单纯化疗方案;在毒副作用方面,Rg3联合化疗治疗的骨髓抑制率、胃肠道不良反应发生率均明显低于单纯化疗者,但肝肾功能损害方面两者相当。展开更多
Based on the dynamic framework of Lorenz 96 model,the ensemble prediction system(EPS)containing stochastic forcing has been developed.In this system,effects of stochastic forcing on the model climate state and ensembl...Based on the dynamic framework of Lorenz 96 model,the ensemble prediction system(EPS)containing stochastic forcing has been developed.In this system,effects of stochastic forcing on the model climate state and ensemble mean prediction have been studied.The results show that the climate mean and standard deviation provided by a new computing paradigm by means of introduction of the proper stochastic forcing into numerical model integration process are closer to that of the true value than that made by the non-stochastic forcing.In other words,numerical model integration process with stochastic forcing has positive effect on the model climate state,and the effect is found to be positive mainly in the long lead time.Meanwhile,with respect to ensemble forecast effect yielded by white noise stochastic forcing,most results are better than those provided by no-stochastic forcing,and improvements pertaining to white noise stochastic forcing vary non-monotonically with the increase of the size of white noise.Moreover,the effects made by the identical white noise stochastic forcing also are different in various non-linear systems.With respect to EPS effect yielded by red noise stochastic forcing,most results are better than those provided by no-stochastic forcing,but only a part of ensemble forecast effect influenced by red noise is superior to that influenced by white noise.Finally,improvements pertaining to red noise stochastic forcing vary non-symmetrically and non-monotonically with the distribution of coefficientΦ.Besides,the selection of correlation coefficientΦis also dependent on non-linear models.展开更多
文摘本研究选择5种多溴联苯醚同系物（BDE-28、BDE-47、BDE-99、BDE-153和BDE-209）对2种海洋饵料藻（亚心型扁藻和盐生杜氏藻）进行急性毒性试验。96 h半抑制浓度（96 h EC50）计算结果表明,BDE-28和BDE-47的毒性较高,随溴原子取代数的增加,PBDE同系物对海洋饵料藻的毒性呈下降趋势,5种PBDE同系物对亚心形扁藻、盐生杜氏藻的96 h EC50由小及大依次为：BDE-28（128,75μg/L）、BDE-47（114,120μg/L）、BDE-99（383,572μg/L）、BDE-153（996,1249μg/L）和BDE-209（2056,1868μg/L）。目前全球近岸海水中PBDEs浓度尚不会对海洋饵料藻产生急性毒性。海洋微藻对同种PBDE同系物的敏感性差异较大（96 h EC50相差1~2个数量级）,为客观评价PBDEs的海洋生态风险性,应研究PBDEs对更多种类微藻的毒性效应。
基金The authors would like to thank Yunnan Provincial Key Programs of Yunnan Eco-friendly Food International Cooperation Research Center Project under Grant 2019ZG00908 and Key Research Program of Frontier Sciences“Response of Asian mountain ecosystems to global change”,CAS,Grant No.QYZDY-SSWSMC014We also thank to the director Jun-Bo Yang and Plant Germplasm and Genomics Center in Germplasm Bank of Wild Species,Kunming Institute of Botany for the molecular laboratory support.Kevin D.Hyde thanks the 2019 high-end foreign expert introduction plan to Kunming Institute of Botany(Granted by the Ministry of Science and Technology of the People’s Republic of China,Grant Number G20190139006)+6 种基金Thailand Research Grants entitled Biodiversity,phylogeny and role of fungal endophytes on above parts of Rhizophora apiculata and Nypa fruticans(Grant No.RSA5980068)the future of specialist fungi in a changing climate:baseline data for generalist and specialist fungi associated with ants,Rhododendron species and Dracaena species(Grant No.DBG6080013)Impact of climate change on fungal diversity and biogeography in the Greater Mekong Subregion(Grant No.RDG6130001)Kevin D.Hyde also thanks Chiang Mai University for the award of visiting Professor.The authors extend their appreciation to the International Scientific Partnership Program ISPP at King Saud University for funding this research work through ISPP#0089.Rungtiwa Phookamsak thanks CAS President’s International Fellowship Initiative(PIFI)for young staff(Grant No.Y9215811Q1)the Yunnan Provincial Department of Human Resources and Social Security(Grant No.Y836181261)National Science Foundation of China(NSFC)Project Code 31850410489(Grant No.Y81I982211)for financial support.Dr.Shaun Pennycook and Prof Eric H.C.McKenzie are thanked for his essential nomenclatural reviewRajesh Jeewon thanks Mae Fah Luang University for the award of a Visiting Scholar and University of Mauritius for research support.Jian-Kui Liu thanks the National Natural Science Foundation of China(NSFC 316000
文摘Fungal diversity notes is one of the important journal series of fungal taxonomy that provide detailed descriptions and illustrations of new fungal taxa,as well as providing new information of fungal taxa worldwide.This article is the 11th contribution to the fungal diversity notes series,in which 126 taxa distributed in two phyla,six classes,24 orders and 55 families are described and illustrated.Taxa in this study were mainly collected from Italy by Erio Camporesi and also collected from China,India and Thailand,as well as in some other European,North American and South American countries.Taxa described in the present study include two new families,12 new genera,82 new species,five new combinations and 25 new records on new hosts and new geographical distributions as well as sexual-asexual reports.The two new families are Eriomycetaceae(Dothideomycetes,family incertae sedis)and Fasciatisporaceae(Xylariales,Sordariomycetes).The twelve new genera comprise Bhagirathimyces(Phaeosphaeriaceae),Camporesiomyces(Tubeufiaceae),Eriocamporesia(Cryphonectriaceae),Eriomyces(Eriomycetaceae),Neomonodictys(Pleurotheciaceae),Paraloratospora(Phaeosphaeriaceae),Paramonodictys(Parabambusicolaceae),Pseudoconlarium(Diaporthomycetidae,genus incertae sedis),Pseudomurilentithecium(Lentitheciaceae),Setoapiospora(Muyocopronaceae),Srinivasanomyces(Vibrisseaceae)and Xenoanthostomella(Xylariales,genera incertae sedis).The 82 new species comprise Acremonium chiangraiense,Adustochaete nivea,Angustimassarina camporesii,Bhagirathimyces himalayensis,Brunneoclavispora camporesii,Camarosporidiella camporesii,Camporesiomyces mali,Camposporium appendiculatum,Camposporium multiseptatum,Camposporium septatum,Canalisporium aquaticium,Clonostachys eriocamporesiana,Clonostachys eriocamporesii,Colletotrichum hederiicola,Coniochaeta vineae,Conioscypha verrucosa,Cortinarius ainsworthii,Cortinarius aurae,Cortinarius britannicus,Cortinarius heatherae,Cortinarius scoticus,Cortinarius subsaniosus,Cytospora fusispora,Cytospora rosigena,Diaporthe camporesii,Diapor
文摘目的系统评价Rg3联合化疗治疗中晚期非小细胞肺癌的临床疗效及安全性。方法在CNKI、CBM、VIP、万方数据库、the Cochrane Central Register of Controlled Trials(CENTRAL)、Pub Med、EMbase、the ISI Web of Knowledge Databases数据库中检索相关研究,日期截至2015年3月。纳入Rg3联合化疗治疗非小细胞肺癌(Rg3联合化疗组)及单纯化疗(单纯化疗组)的随机对照试验,并用Rev Man 5.2统计软件进行Meta分析。结果纳入14项研究,包括833例晚期非小细胞肺癌患者。Meta分析结果显示:Rg3联合化疗组的疗效与单纯化疗组比较,差异有高度统计学意义(OR=1.72,95%CI=1.27~2.33,P=0.0005),且与单纯化疗组比较,Rg3联合化疗组中1年生存率(OR=2.12,95%CI=1.29~3.50,P=0.003)、KPS评分(OR=4.99,95%CI=2.87~8.65,P<0.0001)提高。两组血清VEGF水平(MD=-39.61,95%CI=-61.11^-18.11,P=0.0003)、白细胞减少(OR=0.36,95%CI=0.22~0.59,P<0.0001)、血小板减少(OR=0.27,95%CI=0.11~0.68,P=0.005)及胃肠道不良反应(OR=0.41,95%CI=0.21~0.81,P=0.01)差异均有高度统计学意义,但两组肝肾功能不良反应发生率(OR=0.62,95%CI=0.18~2.12,P=0.44)差异无统计学意义。结论在治疗晚期非小细胞肺癌疗效方面,Rg3与化疗方案联合优于单纯化疗方案;在毒副作用方面,Rg3联合化疗治疗的骨髓抑制率、胃肠道不良反应发生率均明显低于单纯化疗者,但肝肾功能损害方面两者相当。
基金Supported by National Natural Science Foundation of China(41205073,41275099)General Program of Nanjing Joint Center of Atmospheric Research(NJCAR2016MS02)
文摘Based on the dynamic framework of Lorenz 96 model,the ensemble prediction system(EPS)containing stochastic forcing has been developed.In this system,effects of stochastic forcing on the model climate state and ensemble mean prediction have been studied.The results show that the climate mean and standard deviation provided by a new computing paradigm by means of introduction of the proper stochastic forcing into numerical model integration process are closer to that of the true value than that made by the non-stochastic forcing.In other words,numerical model integration process with stochastic forcing has positive effect on the model climate state,and the effect is found to be positive mainly in the long lead time.Meanwhile,with respect to ensemble forecast effect yielded by white noise stochastic forcing,most results are better than those provided by no-stochastic forcing,and improvements pertaining to white noise stochastic forcing vary non-monotonically with the increase of the size of white noise.Moreover,the effects made by the identical white noise stochastic forcing also are different in various non-linear systems.With respect to EPS effect yielded by red noise stochastic forcing,most results are better than those provided by no-stochastic forcing,but only a part of ensemble forecast effect influenced by red noise is superior to that influenced by white noise.Finally,improvements pertaining to red noise stochastic forcing vary non-symmetrically and non-monotonically with the distribution of coefficientΦ.Besides,the selection of correlation coefficientΦis also dependent on non-linear models.
