AIM To establish a method of labeling anti hepatoma McAb (HAb18) Fab fragment modifier with 99m Tc. METHODS HAb18 Fab was modified with 2 iminotholane and labeled with 99m Tc by transchelation f...AIM To establish a method of labeling anti hepatoma McAb (HAb18) Fab fragment modifier with 99m Tc. METHODS HAb18 Fab was modified with 2 iminotholane and labeled with 99m Tc by transchelation from 99m Tc GH. Labeling yield, radiochemical purity and immunoreactivity were determined by thin layer chromatography (TLC SG), paper chromatography (PC), gel chromatography (GC) and cell binding assay, respectively. The nude mice bearing human hepatoma were used for radioimmunoimaging (RII). RESULTS A radiolabeling yield of 50%-80% was obtained, and immunoreactivity (IR) was 30%-40%. Radioimaging results showed that 99m Tc HAb18 McAb Fab fragment was concentrated in the tumor 4-8 hours after injection, and the maximum concentration was seen in 12-24 hours, and the T/NT value was 5 18 and 7 48 at 6h and 8h after the injection. CONCLUSION 99m Tc HAb18 McAb Fab fragment could be specifically localized in the tumor of nude mice bearing human hepatocellular carcinoma within 24 hours and this method might be effectively used for labeling McAb Fab fragment with展开更多
本文设计了一种新的深度神经网络(New Deep Neural Network,NDNN)模型,并将其应用到入侵检测系统中.NDNN以其突出的特征学习能力充分学习训练数据的特征,在输出层,NDNN通过Softmax分类器对网络攻击报文与正常报文数据进行识别和分类,检...本文设计了一种新的深度神经网络(New Deep Neural Network,NDNN)模型,并将其应用到入侵检测系统中.NDNN以其突出的特征学习能力充分学习训练数据的特征,在输出层,NDNN通过Softmax分类器对网络攻击报文与正常报文数据进行识别和分类,检测异常报文与入侵攻击.实验通过对KDD Cup 99数据集进行仿真,实验结果表明本文设计的基于NDNN的入侵检测系统模型,进一步提高了入侵检测系统的精度,增强了网络的安全性.展开更多
Taking the affinity between events and media as a conceptualization base, a total of 1032 related news re-ports of Expo '99 Kunming, gathered from the internet data bank of China INFOBANK from 1992 to 2003, are us...Taking the affinity between events and media as a conceptualization base, a total of 1032 related news re-ports of Expo '99 Kunming, gathered from the internet data bank of China INFOBANK from 1992 to 2003, are used as data sources. After classifying them with a communication research method-the content analysis, a data bank for SPSS is set up, and a mathematic model called the Integrated Impact Index of Expo '99 Kunming is constituted. With the model, the spatial distribution of the total integrated impacts of Expo '99 Kunming on the regions or cities with different regional scales is analysed quantitatively. The conclusions are: 1) the Expo '99 Kunming made obvious integrated impacts on the regions or cities of every scale, especially in the venue city and the region-Kunming City and Yunnan Province; 2) it had corresponding impacts on other provinces; 3) the spatial distribution of Integrated Impact Index had a disaggregation with both plane extension and spotted decentralization; and 4) there was a distance decay law in all three scales of regions (Kunming City, Yunnan Province and the whole China), which incarnated the spatial extension law of the integrated impact of a special mega-event.展开更多
文摘目的核磁共振成像(magnetic reaonance imaging,MRI)能够早期检测鼻咽癌的颅底骨侵犯灶,是治疗前标准检查。而SPECT/CT和CT检测颅底骨侵犯的价值尚不明确。本研究对比分析SPECT/CT和CT对鼻咽癌(nasopharyngeal carcinoma,NPC)颅底骨侵犯(skull base bone involvemen,SBBI)检测能力及临床价值。方法对2014-01-01-2015-12-31玉林市第一人民医院165例NPC初治患者于放疗前同期进行SPECT/CT颅底断层骨显像,鼻咽颅底CT、MRI检查。以MRI结果为标准,采用双盲法对两者检测结果进行比较。根据肿瘤的不同侵犯途径,进一步把颅底骨分斜坡、岩尖,蝶骨体、蝶窦底和翼突、翼板等区域进行统计分析。结果 SPECT/CT和CT检测颅底骨破坏灵敏度分别为96.7%(89/92)和60.9%(56/92),特异度分别为72.6%(53/73)和95.9%(70/73),准确度分别为86.1%(142/165)和76.4%(126/165),Kappa值分别为0.711和0.542。SPECT/CT和CT的AUC值(ROC曲线下面积)分别为0.847和0.784,分别与曲线下面积0.5行Z检验比较,差异有统计学意义,Z=12.43,P<0.001;Z=10.09,P<0.001。在斜坡和岩尖区域,SPECT/CT和CT检测SBBI灵敏度分别为96.7%(88/91)和57.1%(52/91),特异性分别为89.2%(66/74)和100.0%(74/74),准确度值分别为93.3%(154/165)和76.4%(126/165),SPECT/CT和CT检测AUC值分别为0.929和0.786,两者差异有统计学意义,Z=4.425,P<0.001。结论 SPECT/CT和CT能有效地检测鼻咽癌SBBI,在斜坡、岩尖区域,SPECT/CT检测效能优于CT。
文摘AIM To establish a method of labeling anti hepatoma McAb (HAb18) Fab fragment modifier with 99m Tc. METHODS HAb18 Fab was modified with 2 iminotholane and labeled with 99m Tc by transchelation from 99m Tc GH. Labeling yield, radiochemical purity and immunoreactivity were determined by thin layer chromatography (TLC SG), paper chromatography (PC), gel chromatography (GC) and cell binding assay, respectively. The nude mice bearing human hepatoma were used for radioimmunoimaging (RII). RESULTS A radiolabeling yield of 50%-80% was obtained, and immunoreactivity (IR) was 30%-40%. Radioimaging results showed that 99m Tc HAb18 McAb Fab fragment was concentrated in the tumor 4-8 hours after injection, and the maximum concentration was seen in 12-24 hours, and the T/NT value was 5 18 and 7 48 at 6h and 8h after the injection. CONCLUSION 99m Tc HAb18 McAb Fab fragment could be specifically localized in the tumor of nude mice bearing human hepatocellular carcinoma within 24 hours and this method might be effectively used for labeling McAb Fab fragment with
文摘本文设计了一种新的深度神经网络(New Deep Neural Network,NDNN)模型,并将其应用到入侵检测系统中.NDNN以其突出的特征学习能力充分学习训练数据的特征,在输出层,NDNN通过Softmax分类器对网络攻击报文与正常报文数据进行识别和分类,检测异常报文与入侵攻击.实验通过对KDD Cup 99数据集进行仿真,实验结果表明本文设计的基于NDNN的入侵检测系统模型,进一步提高了入侵检测系统的精度,增强了网络的安全性.
基金Under the auspices of National Natural Science Foundation of China (No 40171027)Natural Science Foundation of Guangdong Province (No 5301104)Soft Science Foundation of Guangdong Province (No 2005B70101058)
文摘Taking the affinity between events and media as a conceptualization base, a total of 1032 related news re-ports of Expo '99 Kunming, gathered from the internet data bank of China INFOBANK from 1992 to 2003, are used as data sources. After classifying them with a communication research method-the content analysis, a data bank for SPSS is set up, and a mathematic model called the Integrated Impact Index of Expo '99 Kunming is constituted. With the model, the spatial distribution of the total integrated impacts of Expo '99 Kunming on the regions or cities with different regional scales is analysed quantitatively. The conclusions are: 1) the Expo '99 Kunming made obvious integrated impacts on the regions or cities of every scale, especially in the venue city and the region-Kunming City and Yunnan Province; 2) it had corresponding impacts on other provinces; 3) the spatial distribution of Integrated Impact Index had a disaggregation with both plane extension and spotted decentralization; and 4) there was a distance decay law in all three scales of regions (Kunming City, Yunnan Province and the whole China), which incarnated the spatial extension law of the integrated impact of a special mega-event.
