3,7-Dinitrodibenzobromonium bisulfate 3 was prepared directly by the reaction of4,4’ -dinitrobiphenyl with sodium bromide and potassium persulfate in the concentrated sulphuric acid. Metathetical reactions of 3 gave ...3,7-Dinitrodibenzobromonium bisulfate 3 was prepared directly by the reaction of4,4’ -dinitrobiphenyl with sodium bromide and potassium persulfate in the concentrated sulphuric acid. Metathetical reactions of 3 gave 3, T-dinitrodibenzobromonium chloride 4, bromide 5 and iodide 6, respectively. Crystal structure of 3a obtained by crystallization of 3 in formic acid showed that each molecule of 3a consists of two dibenzobromonium ions, two bisulfate anions and a formic acid. The dibenzobromonium ion is nearly coplanar. Compound 3 can dramatically increase mice’s immunofunction.展开更多
We evaluated the inhibitory effect of 3,7-dini-trodibenzobromonium salts(cBr)on the proliferation of human chronic myelogenous leukemia K_(562)cell by trypan blue exclusion test and MTT colorimetric assay.The degree o...We evaluated the inhibitory effect of 3,7-dini-trodibenzobromonium salts(cBr)on the proliferation of human chronic myelogenous leukemia K_(562)cell by trypan blue exclusion test and MTT colorimetric assay.The degree of DNA damage in K_(562)cells treated with cBr,was detected by isotopic tracer method(^(3)H-TdR).The morphological changes of these K_(562)cells were examined by fluorescence and electron microscopy.Biochemical characteristics of K_(562)cells were detected by flow cytometry and ^(3)H-thymidine incorporation assay.Findings indicated that cBr could significantly inhibit cell proliferation and result in DNA damage of K_(562)cells.cBr is a new type of immunostimulant and can induce cell apoptosis.展开更多
基金Project supported by the National Natural Science Foundation of China
文摘3,7-Dinitrodibenzobromonium bisulfate 3 was prepared directly by the reaction of4,4’ -dinitrobiphenyl with sodium bromide and potassium persulfate in the concentrated sulphuric acid. Metathetical reactions of 3 gave 3, T-dinitrodibenzobromonium chloride 4, bromide 5 and iodide 6, respectively. Crystal structure of 3a obtained by crystallization of 3 in formic acid showed that each molecule of 3a consists of two dibenzobromonium ions, two bisulfate anions and a formic acid. The dibenzobromonium ion is nearly coplanar. Compound 3 can dramatically increase mice’s immunofunction.
文摘We evaluated the inhibitory effect of 3,7-dini-trodibenzobromonium salts(cBr)on the proliferation of human chronic myelogenous leukemia K_(562)cell by trypan blue exclusion test and MTT colorimetric assay.The degree of DNA damage in K_(562)cells treated with cBr,was detected by isotopic tracer method(^(3)H-TdR).The morphological changes of these K_(562)cells were examined by fluorescence and electron microscopy.Biochemical characteristics of K_(562)cells were detected by flow cytometry and ^(3)H-thymidine incorporation assay.Findings indicated that cBr could significantly inhibit cell proliferation and result in DNA damage of K_(562)cells.cBr is a new type of immunostimulant and can induce cell apoptosis.
