Many environmental contaminants could be transmitted fromparents and generate impairments to their progeny.The 2,4,6-tribromophenol(TBP),a novel brominated flame retardant which has been frequently detected in various...Many environmental contaminants could be transmitted fromparents and generate impairments to their progeny.The 2,4,6-tribromophenol(TBP),a novel brominated flame retardant which has been frequently detected in various organisms,was supposed to be bioaccumulated and intergenerational transmitted in human beings.Previous studies revealed that TBP could disrupt thyroid endocrine system in zebrafish larvae.However,there is no available data regarding the parental and transgenerational toxicity of this contaminant.Thus,in this study adult zebrafish were exposed to environmental contaminated levels of TBP for 60 days to investigate the parental and transgenerational impairments on thyroid endocrine system.Chemical analysis verified the bioaccumulation of TBP in tested organs of parents(concentration:liver>gonads>brain)and its transmission into eggs.For adults,increased thyroid hormones,disturbed transcriptions of related genes and histopathological changes in thyroid follicles indicate obvious thyroid endocrine disruptions.Transgenerational effects are indicated by the increased thyroid hormones both in eggs(maternal source)and in developed larvae(newly synthesized),aswell as disrupted transcriptional profiles of key genes in HPT axis.The overall results suggest that the accumulated TBP could be transmitted from parent to offspring and generate thyroid endocrine disruptions in both generations.展开更多
In this work,the removal of 2,4,6-tribromophenol(TBP)by ferric ion-activated sulfite[Fe(Ⅲ)/S(Ⅳ)]process was systematically investigated with determining the intermediate products and evaluating the influences of som...In this work,the removal of 2,4,6-tribromophenol(TBP)by ferric ion-activated sulfite[Fe(Ⅲ)/S(Ⅳ)]process was systematically investigated with determining the intermediate products and evaluating the influences of some operational conditions and water matrices.Our results show that batching addition of S(Ⅳ)benefits the S(Ⅳ)utilization efficiency and TBP removal,with SO_(4)^(-)being the primary reactive radical accounting for TBA degradation.The maximum TBP removal in the Fe(Ⅲ)/S(Ⅳ)process was observed at pH 4.0 and oxygen is essential in this process.With increasing Fe(Ⅲ)and S(Ⅳ)dosages from 0.05 and 0.1 mmol/L to 0.2 and 2.0 mmol/L,respectively,TBP removal followed trends of first increase then decrease.As the acute toxicity of the TBP solution was significantly reduced,the Fe(Ⅲ)/S(Ⅳ)process was believed to be a good choice in the treatment of TBP.展开更多
基金supported by the National Natural Science Foundation of China(21077104)Knowledge Innovation Program of Guangzhou Institute of Geochemistry,CAS(GIGCX-10-01)the Science and Technology Project of Guangdong Province,China(2009A030902003,2009B030400001,and2009B091300023)~~
基金supported by the National Natural Science Foundation of China(Nos. 21737005, 21976207)
文摘Many environmental contaminants could be transmitted fromparents and generate impairments to their progeny.The 2,4,6-tribromophenol(TBP),a novel brominated flame retardant which has been frequently detected in various organisms,was supposed to be bioaccumulated and intergenerational transmitted in human beings.Previous studies revealed that TBP could disrupt thyroid endocrine system in zebrafish larvae.However,there is no available data regarding the parental and transgenerational toxicity of this contaminant.Thus,in this study adult zebrafish were exposed to environmental contaminated levels of TBP for 60 days to investigate the parental and transgenerational impairments on thyroid endocrine system.Chemical analysis verified the bioaccumulation of TBP in tested organs of parents(concentration:liver>gonads>brain)and its transmission into eggs.For adults,increased thyroid hormones,disturbed transcriptions of related genes and histopathological changes in thyroid follicles indicate obvious thyroid endocrine disruptions.Transgenerational effects are indicated by the increased thyroid hormones both in eggs(maternal source)and in developed larvae(newly synthesized),aswell as disrupted transcriptional profiles of key genes in HPT axis.The overall results suggest that the accumulated TBP could be transmitted from parent to offspring and generate thyroid endocrine disruptions in both generations.
基金The support by the National Natural Science Foundation of China(No.51878308)the Young Top-notch Talent Cultivation Program of Hubei Province。
文摘In this work,the removal of 2,4,6-tribromophenol(TBP)by ferric ion-activated sulfite[Fe(Ⅲ)/S(Ⅳ)]process was systematically investigated with determining the intermediate products and evaluating the influences of some operational conditions and water matrices.Our results show that batching addition of S(Ⅳ)benefits the S(Ⅳ)utilization efficiency and TBP removal,with SO_(4)^(-)being the primary reactive radical accounting for TBA degradation.The maximum TBP removal in the Fe(Ⅲ)/S(Ⅳ)process was observed at pH 4.0 and oxygen is essential in this process.With increasing Fe(Ⅲ)and S(Ⅳ)dosages from 0.05 and 0.1 mmol/L to 0.2 and 2.0 mmol/L,respectively,TBP removal followed trends of first increase then decrease.As the acute toxicity of the TBP solution was significantly reduced,the Fe(Ⅲ)/S(Ⅳ)process was believed to be a good choice in the treatment of TBP.
