The most common index for representing structural condition of the pavement is the structural number.The current procedure for determining structural numbers involves utilizing falling weight deflectometer and ground-...The most common index for representing structural condition of the pavement is the structural number.The current procedure for determining structural numbers involves utilizing falling weight deflectometer and ground-penetrating radar tests,recording pavement surface deflections,and analyzing recorded deflections by back-calculation manners.This procedure has two drawbacks:falling weight deflectometer and ground-penetrating radar are expensive tests;back-calculation ways has some inherent shortcomings compared to exact methods as they adopt a trial and error approach.In this study,three machine learning methods entitled Gaussian process regression,M5P model tree,and random forest used for the prediction of structural numbers in flexible pavements.Dataset of this paper is related to 759 flexible pavement sections at Semnan and Khuzestan provinces in Iran and includes“structural number”as output and“surface deflections and surface temperature”as inputs.The accuracy of results was examined based on three criteria of R,MAE,and RMSE.Among the methods employed in this paper,random forest is the most accurate as it yields the best values for above criteria(R=0.841,MAE=0.592,and RMSE=0.760).The proposed method does not require to use ground penetrating radar test,which in turn reduce costs and work difficulty.Using machine learning methods instead of back-calculation improves the calculation process quality and accuracy.展开更多
Wide hybridization is a strategy for broadening the genetic basis of wheat. Because an efficient method for inducing wheat–alien chromosome translocations will allow producing useful germplasm, it is desirable to dis...Wide hybridization is a strategy for broadening the genetic basis of wheat. Because an efficient method for inducing wheat–alien chromosome translocations will allow producing useful germplasm, it is desirable to discover new genes that induce chromosomal variation. In this study, chromosome 5P from A.cristatum was shown to induce many types of chromosomal structural variation in a common wheat background, including nonhomoeologous chromosome translocations, as revealed by genomic in situ hybridization, fluorescence in situ hybridization, and DNA marker analysis. Aberrant meiosis was associated with chromosomal structural variation, and aberrant meiotic behavior was observed in wheat–A.cristatum 5P monosomic and disomic addition lines, suggesting that the effect of chromosome 5P was independent of the number of chromosome 5P copies. Chromosome 5P disturbed homologous chromosome pairing at pachytene stage in a common wheat background, resulting in a high frequency of univalent formation and reduced crossing over. Thirteen genes involved in DNA repair or chromatin remodeling, including RAD52-like and MSH6 genes, were differentially expressed(upregulated) in wheat–A. cristatum 5P addition lines according to transcriptome analysis, implicating chromosome 5P in the process of meiotic double-strand break repair. These findings provide a new, efficient tool for inducing wheat–alien chromosome translocations and producing new germplasm.展开更多
目的观察正常人肝细胞系LO_2和肝癌细胞系SMMC-7721中miR-1247-5p的表达,研究去甲基化药物5-杂氮-2'脱氧胞苷(5-Aza-CdR)对肝癌细胞系SMMC-7721中miR-1247-5p表达及其基因启动子区Cp G岛甲基化水平的影响。方法用不同浓度(0、5和10...目的观察正常人肝细胞系LO_2和肝癌细胞系SMMC-7721中miR-1247-5p的表达,研究去甲基化药物5-杂氮-2'脱氧胞苷(5-Aza-CdR)对肝癌细胞系SMMC-7721中miR-1247-5p表达及其基因启动子区Cp G岛甲基化水平的影响。方法用不同浓度(0、5和10μmol/L)去甲基化药物5-杂氮-2'脱氧胞苷处理SMMC-7721细胞,用甲基化特异性PCR法检测miR-1247-5p基因启动子区甲基化水平;用SYBR Green qReal Time PCR法检测miR-1247-5p的表达。结果与正常人肝细胞系LO_2相比,肝癌细胞系SMMC-7721中miR-1247-5p表达降低(P<0.05)且其基因启动子区Cp G岛甲基化水平高;经去甲基化药物干预后miR-1247-5p的表达较对照组有明显上调(P<0.01),且其基因启动子区Cp G岛甲基化水平降低。结论 miR-1247-5p基因甲基化调控可能参与了肝癌的发生。展开更多
环境法律和政策的核心是作出艰难的决策,它需要全盘考虑科学、经济、法律和政治问题,更不用说不可避免的权衡问题。虽然环境法可能具有让人畏惧的复杂性,但实践证明理解机制选择可以简明易懂。或许让人有点惊讶的是,只有5个基本的政策...环境法律和政策的核心是作出艰难的决策,它需要全盘考虑科学、经济、法律和政治问题,更不用说不可避免的权衡问题。虽然环境法可能具有让人畏惧的复杂性,但实践证明理解机制选择可以简明易懂。或许让人有点惊讶的是,只有5个基本的政策机制扮演角色,这些政策机制通过一个简单的"5P’s(The Five P’s)"框架可以被有效的讲授。5P’s包括指令性规范、财产权、经济惩罚、财政支付和说服。几乎没有哪种机制是解决某一问题的最佳工具,机制选择面临诸多挑战在于识别每种机制内在的优势和劣势。展开更多
Dye effluents with low BOD/COD ratio and varied chemical structures are usually very recalcitrant to microbial degradation. Therefore, different process was used for the treatment of dye effluent. Heterogeneous photoc...Dye effluents with low BOD/COD ratio and varied chemical structures are usually very recalcitrant to microbial degradation. Therefore, different process was used for the treatment of dye effluent. Heterogeneous photocatalyst process has been widely used as leading green technology for dye removal. The process utilizes a semiconductor photocatalyst (such as TiO2 or ZnO) and UV light to oxidize the recalcitrant organic compounds to inorganic ions, carbon dioxide and water. Photocatalytic process needs to photorectors and hydraulic parameters play an important role in mass transfer phenomenon in photocatalytic reactors. These fundamental parameters are flow rate, relative roughness and Reynolds number. This research experimentally evaluates flow rate and artificial relative roughness in order to determine the factors influencing the removal efficiency and reaction rate. For this purpose, a cascade photocatalytic reactor is constructed which consists of similar Plexiglas plates coated by various roughness. Numerical simulation usually overcomes complex reactor models which takes reasonable cost respect to experimental study. Here, OpenFOAM software is also utilized to perform a numerical study. Regime and velocity of sewage are simulated in photocatalytic flow with/without considering relative roughness.展开更多
文摘The most common index for representing structural condition of the pavement is the structural number.The current procedure for determining structural numbers involves utilizing falling weight deflectometer and ground-penetrating radar tests,recording pavement surface deflections,and analyzing recorded deflections by back-calculation manners.This procedure has two drawbacks:falling weight deflectometer and ground-penetrating radar are expensive tests;back-calculation ways has some inherent shortcomings compared to exact methods as they adopt a trial and error approach.In this study,three machine learning methods entitled Gaussian process regression,M5P model tree,and random forest used for the prediction of structural numbers in flexible pavements.Dataset of this paper is related to 759 flexible pavement sections at Semnan and Khuzestan provinces in Iran and includes“structural number”as output and“surface deflections and surface temperature”as inputs.The accuracy of results was examined based on three criteria of R,MAE,and RMSE.Among the methods employed in this paper,random forest is the most accurate as it yields the best values for above criteria(R=0.841,MAE=0.592,and RMSE=0.760).The proposed method does not require to use ground penetrating radar test,which in turn reduce costs and work difficulty.Using machine learning methods instead of back-calculation improves the calculation process quality and accuracy.
基金financially supported by the National Key Research and Development Program of China (2021YFD1200605)the National Natural Science Foundation of China (32171961)。
文摘Wide hybridization is a strategy for broadening the genetic basis of wheat. Because an efficient method for inducing wheat–alien chromosome translocations will allow producing useful germplasm, it is desirable to discover new genes that induce chromosomal variation. In this study, chromosome 5P from A.cristatum was shown to induce many types of chromosomal structural variation in a common wheat background, including nonhomoeologous chromosome translocations, as revealed by genomic in situ hybridization, fluorescence in situ hybridization, and DNA marker analysis. Aberrant meiosis was associated with chromosomal structural variation, and aberrant meiotic behavior was observed in wheat–A.cristatum 5P monosomic and disomic addition lines, suggesting that the effect of chromosome 5P was independent of the number of chromosome 5P copies. Chromosome 5P disturbed homologous chromosome pairing at pachytene stage in a common wheat background, resulting in a high frequency of univalent formation and reduced crossing over. Thirteen genes involved in DNA repair or chromatin remodeling, including RAD52-like and MSH6 genes, were differentially expressed(upregulated) in wheat–A. cristatum 5P addition lines according to transcriptome analysis, implicating chromosome 5P in the process of meiotic double-strand break repair. These findings provide a new, efficient tool for inducing wheat–alien chromosome translocations and producing new germplasm.
文摘目的观察正常人肝细胞系LO_2和肝癌细胞系SMMC-7721中miR-1247-5p的表达,研究去甲基化药物5-杂氮-2'脱氧胞苷(5-Aza-CdR)对肝癌细胞系SMMC-7721中miR-1247-5p表达及其基因启动子区Cp G岛甲基化水平的影响。方法用不同浓度(0、5和10μmol/L)去甲基化药物5-杂氮-2'脱氧胞苷处理SMMC-7721细胞,用甲基化特异性PCR法检测miR-1247-5p基因启动子区甲基化水平;用SYBR Green qReal Time PCR法检测miR-1247-5p的表达。结果与正常人肝细胞系LO_2相比,肝癌细胞系SMMC-7721中miR-1247-5p表达降低(P<0.05)且其基因启动子区Cp G岛甲基化水平高;经去甲基化药物干预后miR-1247-5p的表达较对照组有明显上调(P<0.01),且其基因启动子区Cp G岛甲基化水平降低。结论 miR-1247-5p基因甲基化调控可能参与了肝癌的发生。
文摘环境法律和政策的核心是作出艰难的决策,它需要全盘考虑科学、经济、法律和政治问题,更不用说不可避免的权衡问题。虽然环境法可能具有让人畏惧的复杂性,但实践证明理解机制选择可以简明易懂。或许让人有点惊讶的是,只有5个基本的政策机制扮演角色,这些政策机制通过一个简单的"5P’s(The Five P’s)"框架可以被有效的讲授。5P’s包括指令性规范、财产权、经济惩罚、财政支付和说服。几乎没有哪种机制是解决某一问题的最佳工具,机制选择面临诸多挑战在于识别每种机制内在的优势和劣势。
文摘Dye effluents with low BOD/COD ratio and varied chemical structures are usually very recalcitrant to microbial degradation. Therefore, different process was used for the treatment of dye effluent. Heterogeneous photocatalyst process has been widely used as leading green technology for dye removal. The process utilizes a semiconductor photocatalyst (such as TiO2 or ZnO) and UV light to oxidize the recalcitrant organic compounds to inorganic ions, carbon dioxide and water. Photocatalytic process needs to photorectors and hydraulic parameters play an important role in mass transfer phenomenon in photocatalytic reactors. These fundamental parameters are flow rate, relative roughness and Reynolds number. This research experimentally evaluates flow rate and artificial relative roughness in order to determine the factors influencing the removal efficiency and reaction rate. For this purpose, a cascade photocatalytic reactor is constructed which consists of similar Plexiglas plates coated by various roughness. Numerical simulation usually overcomes complex reactor models which takes reasonable cost respect to experimental study. Here, OpenFOAM software is also utilized to perform a numerical study. Regime and velocity of sewage are simulated in photocatalytic flow with/without considering relative roughness.
