IM To compare the therapeutic effect of three types of interventional management for pimary liver cancer.METHODS 468 patients with primary liver cancer were randomly allocated to three groups: 138 cases with chemoth...IM To compare the therapeutic effect of three types of interventional management for pimary liver cancer.METHODS 468 patients with primary liver cancer were randomly allocated to three groups: 138 cases with chemotherapy alone using mitomycin C, adriamycin and 5FU (group A); 158 with chemoembolization using lipiodol (group B); and 172 with chemoembolization using lipiodol and gelfoam (group C). All patients were angiographically and sonographically followed up.RESULTS ① 675% patients in group C had the AFP value decreased by more than 50%, which was much higher than 433% ingroup B and 322% in group A; ② The tumor size reduced by ≥50% in 203% of group A, 412% of group B and 448% of group C. There was obvious difference between groups A and group B or C (P<001); ③ The oneyear and threeyear survival rates were 205%±36% and 19%±24% for group A, 513%±44% and 101%±49% for group B, and 630%±24% and 139%±50% for group C respectively. There was obvious difference among the three groups (P<005); ④ The mean survival time for patients in groups A, B and C were 96 months, 161 months and 179 months, respectively.CONCLUSION Chemoembolization with lipiodol and gelfoam is the most effective therapy for primary liver cancer in this study. The position of the embolization should be the far and middle sections of the hepatic artery, and the proximal section should be reserved as the route of the next intraarterial chemoembolization.展开更多
IM To compare the efficacy between a combined chemotherapy of ACNU (nimustine hydrochloride, brand name Nidran), a new nitrosourea agent, and a combined chemotherapy of methylCCNU for advanced gastric cancer.METHOD ...IM To compare the efficacy between a combined chemotherapy of ACNU (nimustine hydrochloride, brand name Nidran), a new nitrosourea agent, and a combined chemotherapy of methylCCNU for advanced gastric cancer.METHOD One hundred and three cases of advanced gastric cancer were randomly allocated into Group A (MeCCNU, 5FU and ADM) and Group B (ACNU, 5FU and ADM). The quality of life (QOL) questionnaire composed of 11 ordinal categorical items was studied in these patients.RESULTS In Group A there was no complete remission (CR) or partial remission (PR), while in Group B, although there was no CR, there were 8 PR (8/46 cases), denoting the response rate of 0% in Group A and 174% in Group B. The median survival time in Group A was 108 days and in Group B 112 days. Both groups tolerated well during the treatment and there were no serious adverse effects. QOL evaluations showed better psychological and physical feelings of tiredness in Group B than in Group A, and scores of face scale had more pleasant inclination.CONCLUSION ACNU combination is superior to MeCCNU combination for advanced gastric cancer.展开更多
文摘IM To compare the therapeutic effect of three types of interventional management for pimary liver cancer.METHODS 468 patients with primary liver cancer were randomly allocated to three groups: 138 cases with chemotherapy alone using mitomycin C, adriamycin and 5FU (group A); 158 with chemoembolization using lipiodol (group B); and 172 with chemoembolization using lipiodol and gelfoam (group C). All patients were angiographically and sonographically followed up.RESULTS ① 675% patients in group C had the AFP value decreased by more than 50%, which was much higher than 433% ingroup B and 322% in group A; ② The tumor size reduced by ≥50% in 203% of group A, 412% of group B and 448% of group C. There was obvious difference between groups A and group B or C (P<001); ③ The oneyear and threeyear survival rates were 205%±36% and 19%±24% for group A, 513%±44% and 101%±49% for group B, and 630%±24% and 139%±50% for group C respectively. There was obvious difference among the three groups (P<005); ④ The mean survival time for patients in groups A, B and C were 96 months, 161 months and 179 months, respectively.CONCLUSION Chemoembolization with lipiodol and gelfoam is the most effective therapy for primary liver cancer in this study. The position of the embolization should be the far and middle sections of the hepatic artery, and the proximal section should be reserved as the route of the next intraarterial chemoembolization.
文摘IM To compare the efficacy between a combined chemotherapy of ACNU (nimustine hydrochloride, brand name Nidran), a new nitrosourea agent, and a combined chemotherapy of methylCCNU for advanced gastric cancer.METHOD One hundred and three cases of advanced gastric cancer were randomly allocated into Group A (MeCCNU, 5FU and ADM) and Group B (ACNU, 5FU and ADM). The quality of life (QOL) questionnaire composed of 11 ordinal categorical items was studied in these patients.RESULTS In Group A there was no complete remission (CR) or partial remission (PR), while in Group B, although there was no CR, there were 8 PR (8/46 cases), denoting the response rate of 0% in Group A and 174% in Group B. The median survival time in Group A was 108 days and in Group B 112 days. Both groups tolerated well during the treatment and there were no serious adverse effects. QOL evaluations showed better psychological and physical feelings of tiredness in Group B than in Group A, and scores of face scale had more pleasant inclination.CONCLUSION ACNU combination is superior to MeCCNU combination for advanced gastric cancer.
