The self-duality concept for the Higgs field is handled in the presence of contact geometry in 5 dimensions. A non-trivial SO（3） Higgs field lives only on the fifth dimension of the contact manifold because of the c...The self-duality concept for the Higgs field is handled in the presence of contact geometry in 5 dimensions. A non-trivial SO（3） Higgs field lives only on the fifth dimension of the contact manifold because of the contact structure, while the SD Yang-Mills field lives in the 4-dimensional hyperplane of the contact manifold. The Higgs and SD Yang-Mills fields do not interact with one another.展开更多
目的:本研究依托2013—2014年在北京市城市地区开展的食管癌、胃癌、结直肠癌、肝癌、肺癌和乳腺癌的人群筛查和早诊早治现场,采用欧洲五维健康量表EQ-5D-3L和癌症治疗功能评价量表(Functional Assessment of Cancer Therapy,FACT)对癌...目的:本研究依托2013—2014年在北京市城市地区开展的食管癌、胃癌、结直肠癌、肝癌、肺癌和乳腺癌的人群筛查和早诊早治现场,采用欧洲五维健康量表EQ-5D-3L和癌症治疗功能评价量表(Functional Assessment of Cancer Therapy,FACT)对癌症及癌前病变患者的健康相关生活质量进行测量,并分析EQ-5D-3L和FACT针对北京市癌症人群的信度及效度。方法:采用EQ-5D-3L和FACT同时对1 001例癌症及癌前病变患者进行测量,对EQ-5D-3L及FACT的结果进行Cronbachα系数的内部一致性信度检验,对FACT采用公因子进行结构效度分析,对EQ-5D-3L和FACT进行对比以实现聚合效度的分析。结果 :对于肺癌、乳腺癌、结直肠癌、食管癌、肝癌和胃癌这6种癌症,EQ-5D-3L的Cronbachα系数分别为0.846、0.805、0.877、0.862、0.793和0.844,FACT的Cronbachα系数分别为0.935、0.916、0.950、0.952、0.915和0.953。在结构效度分析中,FACT累积解释方差分别为64.28%、65.15%、71.43%、67.21%、64.76%和70.56%。对比FACT,EQ-5D-3L的聚合效度分别为0.592、0.503、0.715、0.672、0.561和0.444,EQ-视觉模拟量表的聚合效度分别为0.553、0.606、0.576、0.579、0.361和0.364。结论 :EQ-5D-3L和FACT应用于北京市癌症及癌前病变患者的生活质量评估,具有较好的信度。FACT 6种癌症量表的结构效度较好,肺癌、乳腺癌、结直肠癌、肝癌和食管癌的EQ-5D-3L量表效度也较好,而胃癌及癌前病变的EQ-5D-3L量表效度一般。展开更多
目的分析2型糖尿病患者的EQ-5D结构效度,以进一步认识和应用。方法资料来自于2010年全国23个省(市)的103个临床试验中心调查资料,对象为9872例15岁及以上的口服降糖药物的2型糖尿病患者。采用验证性因子分析进行结构效度分析,并用PA-OV...目的分析2型糖尿病患者的EQ-5D结构效度,以进一步认识和应用。方法资料来自于2010年全国23个省(市)的103个临床试验中心调查资料,对象为9872例15岁及以上的口服降糖药物的2型糖尿病患者。采用验证性因子分析进行结构效度分析,并用PA-OV递归模型(Path analysis with observed variables)来探索生活质量影响因素。结果量表5个维度可以提取出2个公因子,分别命名为"主动生活质量"和"感知生活质量"。行动、平常活动和自我照顾三维度在"主动生活质量"上因子载荷分别为0.82、0.84和0.88,而疼痛、不舒服在"感知生活质量"上因子载荷分别为0.71和0.56,自我照顾存在跨因子现象。主动和感知生活质量2个初阶因子在"整体生活质量"上的因子载荷分别为0.66和0.88。一阶和二阶验证性因子分析模型适配度均较好,模型稳定。结论验证性因子分析能较好地评价EQ-5D结构效度,并能应用于2型糖尿病患者生活质量影响因素的探索。展开更多
目的了解常驻高原部队官兵健康相关生命质量情况,探讨其与慢性高原病之间的关系。方法分层随机抽取某军区驻高原部队956个样本及该军区驻平原587个对照样本,实施欧洲五维健康量表(Europe health-related quality of life questionnaire ...目的了解常驻高原部队官兵健康相关生命质量情况,探讨其与慢性高原病之间的关系。方法分层随机抽取某军区驻高原部队956个样本及该军区驻平原587个对照样本,实施欧洲五维健康量表(Europe health-related quality of life questionnaire 5 dimensions,EQ-5D)和慢性高原病(Chronic mountain sickness,CMS)检查。采用t检验、卡方检验、线性相关、非参数检验、方差分析等统计方法进行分析。结果高原组行动能力、疼痛或不舒服、焦虑或沮丧各维度评分均显著高于对照组(P<0.05),EQ直观模拟标度尺(EQ visual analogue scale,EQ-VAS)评分显著低于对照组(P<0.05)。行动能力、自我照顾、疼痛或不舒服、焦虑或沮丧各维度与CMS呈显著正相关(P<0.05),EQ-VAS评分与CMS呈显著负相关(P<0.05);疼痛或不舒服与心率和血红蛋白浓度呈显著正相关(P<0.05),EQVAS评分与心率呈显著负相关(P<0.05)。高原组中健康组、轻度CMS组、中重度CMS组各维度和EQ-VAS评分差异显著(P<0.05)。结论常驻高原官兵的健康相关生命质量与CMS的发生有显著相关性。EQ-5D可以对高原官兵,尤其是CMS官兵的健康状况进行全面的评估,为高原卫勤保障措施的制定提供科学依据。展开更多
Background： Although coronary heart disease （CHD） is one of the major cardiovascular diseases, risk factors associated with the health-related quality of life （HRQoL） of CHD patients remain unclear. The present s...Background： Although coronary heart disease （CHD） is one of the major cardiovascular diseases, risk factors associated with the health-related quality of life （HRQoL） of CHD patients remain unclear. The present study was designed to determine the profile and significant factors of the HRQoL in CHD patients.Methods： A cross-sectional study was conducted in rural communities of Fangshan District, Beijing. China. Socio-demographic, lifestyle, and comorbidity information of CHD patients were collected by a structured questionnaire and medical records. HRQoL was measured using European Quality of Life 5-dimensions （EQ-5D） scale and EQ Visual Analog Scale （EQ-VAS）. Multiple linear and logistic regressions were performed to explore the association of potential risk factors with HRQoL scores and each EQ-SD, respectively.Results： Totally, 1928 CHD patients （mean age 61.64 ± 9.24 years; female：male = 2.4：1） were enrolled in the study. The mean score of EQ-5D index and EQ-VAS were 0.889 ±0.172 and 71.56 ±17.65, respectively. Multiple linear regression revealed that marital status, physical activity, moderate alcohol drinking, and family＇s population were positive independent correlates of EQ-VAS, whereas diabetes mellitus and stroke were negative independent correlates （all P 〈 0.05）. Age and stroke were negatively while physical activity, moderate alcohol drinking, family＇s population and household income were positively correlated with EQ-5D index （all P 〈 0.05） independently. In addition, each of the five HRQoL dimensions had various specific determinants, including obesity, underweight. smoking or education. Conclusions： Findings of the study highlight certain socio-demographic, lifestyle factors, and comorbid stroke or diabetes mellitus as correlates of HRQoL in Chinese CHD patients. Large-scale cohort studies should be carried out to confirm our results in the future.展开更多
BACKGROUND Health utility assessments have been developed for various conditions,including chronic liver disease.Health utility scores are required for socio-economic evaluations,which can aid the distribution of nati...BACKGROUND Health utility assessments have been developed for various conditions,including chronic liver disease.Health utility scores are required for socio-economic evaluations,which can aid the distribution of national budgets.However,the standard health utility assessment scores for specific health conditions are largely unknown.AIM To summarize the health utility scores,including the EuroQOL 5-dimensions 5-levels(EQ-5D-5L),EuroQol-visual analogue scale,short from-36(SF-36),RAND-36,and Health Utilities Index(HUI)-Mark2/Mark3 scores,for the normal population and chronic liver disease patients.METHODS A systematic literature search of PubMed and MEDLINE,including the Cochrane Library,was performed.Meta-analysis was performed using the RevMan software.Multiple means and standard deviations were combined using the StatsToDo online web program.RESULTS The EQ-5D-5L and SF-36 can be used for health utility evaluations during antiviral therapy for hepatitis C.HUI-Mark2/Mark3 indicated that the health utility scores of hepatitis B patients are roughly 30% better than those of hepatitis C patients.CONCLUSION The EQ-5D-5L is the most popular questionnaire for health utility assessments.Health assessments that allow free registration would be useful for evaluating health utility in patients with liver disease.展开更多
文摘The self-duality concept for the Higgs field is handled in the presence of contact geometry in 5 dimensions. A non-trivial SO（3） Higgs field lives only on the fifth dimension of the contact manifold because of the contact structure, while the SD Yang-Mills field lives in the 4-dimensional hyperplane of the contact manifold. The Higgs and SD Yang-Mills fields do not interact with one another.
文摘目的:本研究依托2013—2014年在北京市城市地区开展的食管癌、胃癌、结直肠癌、肝癌、肺癌和乳腺癌的人群筛查和早诊早治现场,采用欧洲五维健康量表EQ-5D-3L和癌症治疗功能评价量表(Functional Assessment of Cancer Therapy,FACT)对癌症及癌前病变患者的健康相关生活质量进行测量,并分析EQ-5D-3L和FACT针对北京市癌症人群的信度及效度。方法:采用EQ-5D-3L和FACT同时对1 001例癌症及癌前病变患者进行测量,对EQ-5D-3L及FACT的结果进行Cronbachα系数的内部一致性信度检验,对FACT采用公因子进行结构效度分析,对EQ-5D-3L和FACT进行对比以实现聚合效度的分析。结果 :对于肺癌、乳腺癌、结直肠癌、食管癌、肝癌和胃癌这6种癌症,EQ-5D-3L的Cronbachα系数分别为0.846、0.805、0.877、0.862、0.793和0.844,FACT的Cronbachα系数分别为0.935、0.916、0.950、0.952、0.915和0.953。在结构效度分析中,FACT累积解释方差分别为64.28%、65.15%、71.43%、67.21%、64.76%和70.56%。对比FACT,EQ-5D-3L的聚合效度分别为0.592、0.503、0.715、0.672、0.561和0.444,EQ-视觉模拟量表的聚合效度分别为0.553、0.606、0.576、0.579、0.361和0.364。结论 :EQ-5D-3L和FACT应用于北京市癌症及癌前病变患者的生活质量评估,具有较好的信度。FACT 6种癌症量表的结构效度较好,肺癌、乳腺癌、结直肠癌、肝癌和食管癌的EQ-5D-3L量表效度也较好,而胃癌及癌前病变的EQ-5D-3L量表效度一般。
文摘目的分析2型糖尿病患者的EQ-5D结构效度,以进一步认识和应用。方法资料来自于2010年全国23个省(市)的103个临床试验中心调查资料,对象为9872例15岁及以上的口服降糖药物的2型糖尿病患者。采用验证性因子分析进行结构效度分析,并用PA-OV递归模型(Path analysis with observed variables)来探索生活质量影响因素。结果量表5个维度可以提取出2个公因子,分别命名为"主动生活质量"和"感知生活质量"。行动、平常活动和自我照顾三维度在"主动生活质量"上因子载荷分别为0.82、0.84和0.88,而疼痛、不舒服在"感知生活质量"上因子载荷分别为0.71和0.56,自我照顾存在跨因子现象。主动和感知生活质量2个初阶因子在"整体生活质量"上的因子载荷分别为0.66和0.88。一阶和二阶验证性因子分析模型适配度均较好,模型稳定。结论验证性因子分析能较好地评价EQ-5D结构效度,并能应用于2型糖尿病患者生活质量影响因素的探索。
基金Source of Support： This work was supported by grants from the National Natural Science Foundation of China （No. 81230066, No. 30872173, No. 81172744）. Conflict of Interest： None declared.
文摘Background： Although coronary heart disease （CHD） is one of the major cardiovascular diseases, risk factors associated with the health-related quality of life （HRQoL） of CHD patients remain unclear. The present study was designed to determine the profile and significant factors of the HRQoL in CHD patients.Methods： A cross-sectional study was conducted in rural communities of Fangshan District, Beijing. China. Socio-demographic, lifestyle, and comorbidity information of CHD patients were collected by a structured questionnaire and medical records. HRQoL was measured using European Quality of Life 5-dimensions （EQ-5D） scale and EQ Visual Analog Scale （EQ-VAS）. Multiple linear and logistic regressions were performed to explore the association of potential risk factors with HRQoL scores and each EQ-SD, respectively.Results： Totally, 1928 CHD patients （mean age 61.64 ± 9.24 years; female：male = 2.4：1） were enrolled in the study. The mean score of EQ-5D index and EQ-VAS were 0.889 ±0.172 and 71.56 ±17.65, respectively. Multiple linear regression revealed that marital status, physical activity, moderate alcohol drinking, and family＇s population were positive independent correlates of EQ-VAS, whereas diabetes mellitus and stroke were negative independent correlates （all P 〈 0.05）. Age and stroke were negatively while physical activity, moderate alcohol drinking, family＇s population and household income were positively correlated with EQ-5D index （all P 〈 0.05） independently. In addition, each of the five HRQoL dimensions had various specific determinants, including obesity, underweight. smoking or education. Conclusions： Findings of the study highlight certain socio-demographic, lifestyle factors, and comorbid stroke or diabetes mellitus as correlates of HRQoL in Chinese CHD patients. Large-scale cohort studies should be carried out to confirm our results in the future.
基金Supported by Grants-in-Aid from JSPS KAKENHI,No.JP 20K10404(to Mizuguchi T)and No.JP 21K10715(to Ishinuki T)the Hokkaido Hepatitis B Litigation Orange Fund,No.2059198(to Mizuguchi T)and No.2136589(to Harada K)+14 种基金Terumo Life Science Foundation,No.2000666Pfizer Health Research Foundation,No.2000777the Viral Hepatitis Research Foundation of Japan,No.3039838Project Mirai Cancer Research Grants,No.202110251Takahashi Industrial and Economic Research Foundation,No.12-003-106Daiichi Sankyo Company,No.2109540Shionogi and Co.,No.2109493MSD,No.2099412Takeda Pharmaceutical Company,No.2000555Sapporo Doto Hospital,No.2039118Noguchi Hospital,No.2029083Doki-kai Tomakomai Hospital,No.2059203Tsuchida Hospital,No.2000092Shinyu-kai Noguchi Hospital,No.2029083(to Mizuguchi T)the Yasuda Medical Foundation,No.28-1(to Ishinuki T).
文摘BACKGROUND Health utility assessments have been developed for various conditions,including chronic liver disease.Health utility scores are required for socio-economic evaluations,which can aid the distribution of national budgets.However,the standard health utility assessment scores for specific health conditions are largely unknown.AIM To summarize the health utility scores,including the EuroQOL 5-dimensions 5-levels(EQ-5D-5L),EuroQol-visual analogue scale,short from-36(SF-36),RAND-36,and Health Utilities Index(HUI)-Mark2/Mark3 scores,for the normal population and chronic liver disease patients.METHODS A systematic literature search of PubMed and MEDLINE,including the Cochrane Library,was performed.Meta-analysis was performed using the RevMan software.Multiple means and standard deviations were combined using the StatsToDo online web program.RESULTS The EQ-5D-5L and SF-36 can be used for health utility evaluations during antiviral therapy for hepatitis C.HUI-Mark2/Mark3 indicated that the health utility scores of hepatitis B patients are roughly 30% better than those of hepatitis C patients.CONCLUSION The EQ-5D-5L is the most popular questionnaire for health utility assessments.Health assessments that allow free registration would be useful for evaluating health utility in patients with liver disease.
