A Glaser coupling reaction of terminal alkynes in the presence of cupric chloride without organic solvents and bases under near-critical water has been developed.
A facile catalytic enantioselective 1,2-addition of diynes to trifluoromethyl ketones was developed. By a com- bination of Me2Zn, Ti（OPr-i）4, BaF2 and quinine, the reaction of a series of terminal diynes with triflu...A facile catalytic enantioselective 1,2-addition of diynes to trifluoromethyl ketones was developed. By a com- bination of Me2Zn, Ti（OPr-i）4, BaF2 and quinine, the reaction of a series of terminal diynes with trifluoromethyl ke- tones proceeded to afford trifluoromethylated chrial tertiary alcohols with the diyne moiety in good to high yields with moderate to high enantioselectivities. Furthermore, this catalytic asymmetric diyne addition to trifluoro- methylketone was applied in the synthesis of the Efavirenz analogue.展开更多
A simple and efficient protocol for Fe/Cu cocatalyzed oxidative homocoupling reaction of terminal alkynes to symmetrical 1,4-disubstituted-l,3-diynes was presented. The results showed that both CuBr and FeC13 played e...A simple and efficient protocol for Fe/Cu cocatalyzed oxidative homocoupling reaction of terminal alkynes to symmetrical 1,4-disubstituted-l,3-diynes was presented. The results showed that both CuBr and FeC13 played erucial roles in the reaction. It is noteworthy that this protocol employs mild, efficient, aerobic and ligand free conditions. The alkynes, including aromatic, heteroaromatic and aliphatic alkynes, were transformed into the corresponding 1,3-diynes in good to excellent yields.展开更多
A facile and direct fluorination process of alkynes and diynes was developed, in the presence of n-butyllithium, the reaction of a series of terminal alkynes and diynes with the electrophilic fluorinating reagent （N...A facile and direct fluorination process of alkynes and diynes was developed, in the presence of n-butyllithium, the reaction of a series of terminal alkynes and diynes with the electrophilic fluorinating reagent （NFSI） proceeded to afford various 1-fluoroalkynes and 1-fluoro-l,3-diynes in moderate to high yields.展开更多
以苯乙炔为原料制备1,4-二苯基-1,3-丁二炔。以钯催化自偶联的方法合成对称性芳基丁二炔,通过优化碱、溶剂、反应时间和温度等条件得出最优反应条件。结果表明,采用最优条件,在2 mmol Ag NO3促进作用下,1,4-二苯基-1,3-丁二炔的产率达84...以苯乙炔为原料制备1,4-二苯基-1,3-丁二炔。以钯催化自偶联的方法合成对称性芳基丁二炔,通过优化碱、溶剂、反应时间和温度等条件得出最优反应条件。结果表明,采用最优条件,在2 mmol Ag NO3促进作用下,1,4-二苯基-1,3-丁二炔的产率达84.3%。展开更多
基金Project supported by the National Natural Science Foundation of China (Nos. 2037202420172018)+1 种基金 the Excellent Scientist Foundation of Anhui Province (No. 2001040) the Natural Science Foundation of the Education Department of Anhui Province (No. 2002kj25
文摘A Glaser coupling reaction of terminal alkynes in the presence of cupric chloride without organic solvents and bases under near-critical water has been developed.
文摘A facile catalytic enantioselective 1,2-addition of diynes to trifluoromethyl ketones was developed. By a com- bination of Me2Zn, Ti（OPr-i）4, BaF2 and quinine, the reaction of a series of terminal diynes with trifluoromethyl ke- tones proceeded to afford trifluoromethylated chrial tertiary alcohols with the diyne moiety in good to high yields with moderate to high enantioselectivities. Furthermore, this catalytic asymmetric diyne addition to trifluoro- methylketone was applied in the synthesis of the Efavirenz analogue.
基金We are grateful for financial support from the National Natural Science Foundation of China，the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘A simple and efficient protocol for Fe/Cu cocatalyzed oxidative homocoupling reaction of terminal alkynes to symmetrical 1,4-disubstituted-l,3-diynes was presented. The results showed that both CuBr and FeC13 played erucial roles in the reaction. It is noteworthy that this protocol employs mild, efficient, aerobic and ligand free conditions. The alkynes, including aromatic, heteroaromatic and aliphatic alkynes, were transformed into the corresponding 1,3-diynes in good to excellent yields.
基金This work was supported financially by the National Natural Science Foundation of China （Nos. 20972110 and 21002068）.
文摘A facile and direct fluorination process of alkynes and diynes was developed, in the presence of n-butyllithium, the reaction of a series of terminal alkynes and diynes with the electrophilic fluorinating reagent （NFSI） proceeded to afford various 1-fluoroalkynes and 1-fluoro-l,3-diynes in moderate to high yields.
