The provision of open space is seen as a feasible solution in mitigating the challenges of urbanization,which accomm odates the daily leisure activities of residents and contributes to sustainable developm ent.This st...The provision of open space is seen as a feasible solution in mitigating the challenges of urbanization,which accomm odates the daily leisure activities of residents and contributes to sustainable developm ent.This study aims at understanding how users perceive open space in 29-3 Park in Da Nang,Vietnam.This understanding may help to adopt a better approach to development and improvements.More specifically,it focuses on identifying roles and attributes of the space and determ ining those elements which affect how users of the space gather,based on their perspective.Residents,behaviour param eters were identified and classified based on activities that occurred in this space,and were collected using a behavioural mapping survey method.The analysis of 20 in-depth interviews,and 287 question naires,show existing problems that need to be improved and detail 11 physical factors that have potential to impact on users'satisfaction.These results may have the potential to play an im portant role in assisting designers and administrators to create successful open space in urban areas of Vietnam or other developing countries in the future.展开更多
The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regula...The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells.展开更多
文摘The provision of open space is seen as a feasible solution in mitigating the challenges of urbanization,which accomm odates the daily leisure activities of residents and contributes to sustainable developm ent.This study aims at understanding how users perceive open space in 29-3 Park in Da Nang,Vietnam.This understanding may help to adopt a better approach to development and improvements.More specifically,it focuses on identifying roles and attributes of the space and determ ining those elements which affect how users of the space gather,based on their perspective.Residents,behaviour param eters were identified and classified based on activities that occurred in this space,and were collected using a behavioural mapping survey method.The analysis of 20 in-depth interviews,and 287 question naires,show existing problems that need to be improved and detail 11 physical factors that have potential to impact on users'satisfaction.These results may have the potential to play an im portant role in assisting designers and administrators to create successful open space in urban areas of Vietnam or other developing countries in the future.
基金supported by the National Natural Science Foundation of China(Grant Nos.81630068,31670881,and 81901466)China Postdoctoral Science Foundation(Grant No.2020TQ0282)。
文摘The lung is one of the most common sites for cancer metastasis.Collagens in the lung provide a permissive microenvironment that supports the colonization and outgrowth of disseminated tumor cells.Therefore,down-regulating the production of collagens may contribute to the inhibition of lung metastasis.It has been suggested that mi R-29 exhibits effective anti-fibrotic activity by negatively regulating the expression of collagens.Indeed,our clinical lung tumor data shows that mi R-29 a-3 p expression negatively correlates with collagen I expression in lung tumors and positively correlates with patients’outcomes.However,suitable carriers need to be selected to deliver this therapeutic mi RNA to the lungs.In this study,we found that the chemotherapy drug cisplatin facilitated mi R-29 a-3 p accumulation in the exosomes of lung tumor cells,and this type of exosomes exhibited a specific lung-targeting effect and promising collagen down-regulation.To scale up the preparation and simplify the delivery system,we designed a lung-targeting liposomal nanovesicle(by adjusting the molar ratio of DOTAP/cholesterol-mi RNAs to 4:1)to carry mi R-29 a-3 p and mimic the exosomes.This liposomal nanovesicle delivery system significantly down-regulated collagen I secretion by lung fibroblasts in vivo,thus alleviating the establishment of a pro-metastatic environment for circulating lung tumor cells.
