Lespedezavirgatol,a novel 2-phenylbenzofuran compound which was isolated from Lespedeza virgata,was firstly synthesized from pyrogallic acid and 3,4-dimethoxyphenol as starting materials with 8 steps.The key steps for...Lespedezavirgatol,a novel 2-phenylbenzofuran compound which was isolated from Lespedeza virgata,was firstly synthesized from pyrogallic acid and 3,4-dimethoxyphenol as starting materials with 8 steps.The key steps for the total synthesis were the selective iodination at 3-position of 1,2-dimethoxy-4-methoxymethoxybenzene and the Sonogashira cross-coupling reaction between 4-iodo-2-methoxybenzene-1,3-diol and 2-ethynyl-3,4-dimethoxy-1-(methoxy-methoxy)-benzene.展开更多
基金supported by the National Natural Science Foundation of China(20872038)Research Fund for the Doctoral Program of Higher Education of China(20060561024)
文摘Lespedezavirgatol,a novel 2-phenylbenzofuran compound which was isolated from Lespedeza virgata,was firstly synthesized from pyrogallic acid and 3,4-dimethoxyphenol as starting materials with 8 steps.The key steps for the total synthesis were the selective iodination at 3-position of 1,2-dimethoxy-4-methoxymethoxybenzene and the Sonogashira cross-coupling reaction between 4-iodo-2-methoxybenzene-1,3-diol and 2-ethynyl-3,4-dimethoxy-1-(methoxy-methoxy)-benzene.
