On the premise of maintaining the reducibility of sinter unchanged, it is of great significance to reduce the RDI （reduction degradation index） of sinter, which will improve the permeability of blast furnace burden ...On the premise of maintaining the reducibility of sinter unchanged, it is of great significance to reduce the RDI （reduction degradation index） of sinter, which will improve the permeability of blast furnace burden column, so as to realize stable and smooth performance, and keep high yield and low consumption. Under laboratory conditions, a study on the RDI and RI （reduction index） of sinter was proposed, in which the sinter was immersed in solutions with different types and concentrations. In order to study the mechanism of CaCl2 effect on the RDI and RI of sinter, analysis based on the methods of IR spectra, SEM and chaleography was adopted. The results show that Cl^- is the main factor reducing the RDI of sinter, and the RDI and RI of sinter decrease with the increase of Cl^- concentration. With comprehensive consideration of the RDI and RI of sinter, when the concentration of Cl^ is 2%, the RDI of sinter will be significantly reduced and RI will not be affected.展开更多
目的探讨RAD51抑制剂RI-1对MSH2缺陷结直肠癌细胞系的杀伤作用及可能的作用机制。方法 Western blot法筛选MSH2差异表达的结直肠癌细胞系,MTT法检测不同结直肠癌细胞系对RI-1(10、20、30、40或50μmol/L)的敏感性;构建针对MSH2基因的重...目的探讨RAD51抑制剂RI-1对MSH2缺陷结直肠癌细胞系的杀伤作用及可能的作用机制。方法 Western blot法筛选MSH2差异表达的结直肠癌细胞系,MTT法检测不同结直肠癌细胞系对RI-1(10、20、30、40或50μmol/L)的敏感性;构建针对MSH2基因的重组shRNA慢病毒表达载体并感染HT29细胞。RI-1(40μmol/L)处理细胞,流式细胞术检测细胞凋亡的变化;单细胞凝胶电泳实验分析细胞内DNA损伤情况;细胞免疫荧光法检测γ-H2AX foci的形成。结果与对照组相比MSH2缺陷的HCT8细胞有明显细胞凋亡现象(P<0.01);HCT8细胞和HT29 Shmsh2细胞尾部DNA含量、尾长和尾距均较对照组明显增加(P<0.05);HCT8细胞和HT29 Shmsh2细胞内γ-H2AX foci的形成数量较对照组明显增加(P<0.01)。结论 RAD51抑制剂RI-1可能通过增加细胞内DNA损伤参与RI-1对MSH2缺陷肿瘤的杀伤作用。展开更多
Since the inaugural international collaboration under the framework of the Collaboratory for the Study of Earthquake Predictability(CSEP)in 2007,numerous forecast models have been developed and operated for earthquake...Since the inaugural international collaboration under the framework of the Collaboratory for the Study of Earthquake Predictability(CSEP)in 2007,numerous forecast models have been developed and operated for earthquake forecasting experiments across CSEP testing centers(Schorlemmer et al.,2018).Over more than a decade,efforts to compare forecasts with observed earthquakes using numerous statistical test methods and insights into earthquake predictability,which have become a highlight of the CSEP platform.展开更多
基金Item Sponsored by National Key Fundamental Research and Development Project of China (2006BAE03A01)
文摘On the premise of maintaining the reducibility of sinter unchanged, it is of great significance to reduce the RDI （reduction degradation index） of sinter, which will improve the permeability of blast furnace burden column, so as to realize stable and smooth performance, and keep high yield and low consumption. Under laboratory conditions, a study on the RDI and RI （reduction index） of sinter was proposed, in which the sinter was immersed in solutions with different types and concentrations. In order to study the mechanism of CaCl2 effect on the RDI and RI of sinter, analysis based on the methods of IR spectra, SEM and chaleography was adopted. The results show that Cl^- is the main factor reducing the RDI of sinter, and the RDI and RI of sinter decrease with the increase of Cl^- concentration. With comprehensive consideration of the RDI and RI of sinter, when the concentration of Cl^ is 2%, the RDI of sinter will be significantly reduced and RI will not be affected.
基金granted by the National Natural Science Foundation of China(Grant No.42004038)Earthquake Tracking Orientation Tasks of CEA(Grant No.2024020104)+1 种基金the Special Fund of IEFCEA(Grant No.CEAIEF2022030206)the China Scholarship Council(CSC)exchange program(Grant No.202204190019)。
文摘Since the inaugural international collaboration under the framework of the Collaboratory for the Study of Earthquake Predictability(CSEP)in 2007,numerous forecast models have been developed and operated for earthquake forecasting experiments across CSEP testing centers(Schorlemmer et al.,2018).Over more than a decade,efforts to compare forecasts with observed earthquakes using numerous statistical test methods and insights into earthquake predictability,which have become a highlight of the CSEP platform.
