Objective:To determine the prevalence of optic nerve sheath meningiomas(ONSMs)in patients with neurofibromatosis type 2(NF2).Methods:An observational retrospective case series of 30 consecutive patients with NF2 refer...Objective:To determine the prevalence of optic nerve sheath meningiomas(ONSMs)in patients with neurofibromatosis type 2(NF2).Methods:An observational retrospective case series of 30 consecutive patients with NF2 referred to an academic ophthalmology unit from November 1,1991,through August 31,2003.Twenty-six patients were followed up for a mean of 93 months(range,3-150 months).One individual was lost to follow-up,and 3 had been referred recently.Diagnosis of ONSM was made based on typical neuroradiologic and clinical features in 7 patients and on histologic criteria in 1.Results:Eight of 30 patients harbored unilateral(n=6)or bilateral(n=2)-ONSMs.Six ONSMs were diagnosed at initial examination,and 4 during follow-up.Conclusions:There is a strong association between ONSMs and NF2 that parallels the well-known association of optic nerve gliomas with NF1.Physicians should be aware of the possibility that patients with ONSMs may also have NF2.展开更多
神经鞘瘤（schwannoma）是起源于神经髓鞘的良性肿瘤，是神经系统最常见的良性肿瘤之一。神经鞘瘤可发生于脑神经以及外周神经，目前主要的治疗方法包括手术治疗和立体定向放射治疗。由于2型神经纤维瘤病（neurofibromatosis type 2，NF...神经鞘瘤（schwannoma）是起源于神经髓鞘的良性肿瘤，是神经系统最常见的良性肿瘤之一。神经鞘瘤可发生于脑神经以及外周神经，目前主要的治疗方法包括手术治疗和立体定向放射治疗。由于2型神经纤维瘤病（neurofibromatosis type 2，NF2）、神经鞘瘤病等家族遗传性疾病会造成多发性神经鞘瘤，而目前的治疗方法效果不佳，展开更多
文摘Objective:To determine the prevalence of optic nerve sheath meningiomas(ONSMs)in patients with neurofibromatosis type 2(NF2).Methods:An observational retrospective case series of 30 consecutive patients with NF2 referred to an academic ophthalmology unit from November 1,1991,through August 31,2003.Twenty-six patients were followed up for a mean of 93 months(range,3-150 months).One individual was lost to follow-up,and 3 had been referred recently.Diagnosis of ONSM was made based on typical neuroradiologic and clinical features in 7 patients and on histologic criteria in 1.Results:Eight of 30 patients harbored unilateral(n=6)or bilateral(n=2)-ONSMs.Six ONSMs were diagnosed at initial examination,and 4 during follow-up.Conclusions:There is a strong association between ONSMs and NF2 that parallels the well-known association of optic nerve gliomas with NF1.Physicians should be aware of the possibility that patients with ONSMs may also have NF2.
文摘神经鞘瘤（schwannoma）是起源于神经髓鞘的良性肿瘤，是神经系统最常见的良性肿瘤之一。神经鞘瘤可发生于脑神经以及外周神经，目前主要的治疗方法包括手术治疗和立体定向放射治疗。由于2型神经纤维瘤病（neurofibromatosis type 2，NF2）、神经鞘瘤病等家族遗传性疾病会造成多发性神经鞘瘤，而目前的治疗方法效果不佳，
文摘听神经瘤(acoustic neuroma,AN)是起源于内听道前庭神经鞘膜雪旺细胞的良性肿瘤,也称前庭神经鞘瘤(vestibular schwannomas,VS),占桥小脑脚区肿瘤的80%。通常,VS多为单侧孤立性发生,双侧发病患者为2型神经纤维瘤病(neurofibromatosis type 2,NF2),大约5%~10%的VS患者会被确诊为NF2[1]。
