We report the case of a male patient with Miller-Dieker syndrome(MDS)and gallbladder cancer.Chromosome analysis by fluorescence in situ hybridization revealed a deletion in the 17p13.3 region,an area thought to contai...We report the case of a male patient with Miller-Dieker syndrome(MDS)and gallbladder cancer.Chromosome analysis by fluorescence in situ hybridization revealed a deletion in the 17p13.3 region,an area thought to contain tumour suppressor genes,including the hypermethylated in cancer 1 gene.Considering the rarity of gallbladder cancer in children,we propose that MDS as the genetic background of this patient may have played a role in the occurrence of gallbladder cancer.Conclusion:Our present report indicates that the emergence of cancers should be taken into consideration during the long-term follow-up of patients with MDS.展开更多
文摘We report the case of a male patient with Miller-Dieker syndrome(MDS)and gallbladder cancer.Chromosome analysis by fluorescence in situ hybridization revealed a deletion in the 17p13.3 region,an area thought to contain tumour suppressor genes,including the hypermethylated in cancer 1 gene.Considering the rarity of gallbladder cancer in children,we propose that MDS as the genetic background of this patient may have played a role in the occurrence of gallbladder cancer.Conclusion:Our present report indicates that the emergence of cancers should be taken into consideration during the long-term follow-up of patients with MDS.
