AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences betwee...AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients.展开更多
This study aimed to explore the molecular mechanism in tumor invasion and metastasis. The expression of matrix metalloproteinase 2, 9 (MMP 2, MMP 9), tissue inhibitor 1 of matrix metalloproteinase (TIMP 1), c...This study aimed to explore the molecular mechanism in tumor invasion and metastasis. The expression of matrix metalloproteinase 2, 9 (MMP 2, MMP 9), tissue inhibitor 1 of matrix metalloproteinase (TIMP 1), cell adhesion molecule 44 variant 6 (CD44v6), HER2/neu and p53 was investigated in 154 patients with head and neck squamous cell carcinoma (SCC) by ABC and ImmunoMax immunohistochemical method. Their clinical relevance and correlation were analysed. The expression of MMP 2, MMP 9, TIMP 1, CD44v6, HER2/neu and p53 was found in cancer cells in 87.01%, 85.71%, 68.18%, 98.05%, 55.19% and 50.65% cases respectively. Linear regression and correlation analysis revealed that there was close positive relationship ( P <0.05) between the expression of MMP 2 and MMP 9, TIMP 1 and CD44v6, HER2/neu and MMP 9, MMP 2 and p53. Up regulation of MMP 2 was accompanied by advanced T stage ( P <0.01) . There was also a trend of MMP 2 expression being related with tumor metastasis. Increased expression of HER2/neu was found in patients with tumor recurrence( P <0.05). The expression of TIMP 1 was higher in laryngeal cancer than that in pharyngeal cancer, and higher in keratinizing and non keratinizing SCC than that in basaloid SCC( P <0.05). These findings suggested that MMP 2 and MMP 9, HER2/neu and MMP 9, MMP 2 and p53 had a coordinate function in aggression of tumor; that MMP 2 had a more important function than MMP 9 in tumor invasion and metastasis; and that HER2/neu might serve as a biomarker for poor prognosis in HNSCC.展开更多
Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers...Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers before and after acupuncture atTaichong （LR3） andTaixi （KI3） using resting-state functional magnetic resonance imaging. Fifteen healthy volunteers underwent resting-state functional magnetic resonance imaging of the brain 15 minutes before acupuncture, then received acupuncture atTaichong andTaixi using the nail-pressing needle insertion method, after which the needle was retained in place for 30 minutes. Fifteen minutes after withdrawal of the needle, the volunteers underwent a further session of resting-state functional magnetic res-onance imaging, which revealed that the amplitude of low-frequency lfuctuation, a measure of spontaneous neuronal activity, increased mainly in the cerebral occipital lobe and middle occipital gyrus （Brodmann area 18/19）, inferior occipital gyrus （Brodmann area 18） and cuneus （Brodmann area 18）, but decreased mainly in the gyrus rectus of the frontal lobe （Brodmann area 11）, inferi-or frontal gyrus （Brodmann area 44） and the center of the posterior lobe of the cerebellum. The present ifndings indicate that acupuncture atTaichong andTaixi speciifcally promote blood lfow and activation in the brain areas related to vision, emotion and cognition, and inhibit brain areas related to emotion, attention, phonological and semantic processing, and memory.展开更多
Water and land are the necessary agricultural inputs, and both are scarce these days. This study aims to determine the effect of water application rate on selected planting and crop parameters of Farro 44 rice during ...Water and land are the necessary agricultural inputs, and both are scarce these days. This study aims to determine the effect of water application rate on selected planting and crop parameters of Farro 44 rice during dry season farming and its growth response. The randomised complete block design was employed for the Farro 44 rice variety, with each plot size 4 m<sup>2</sup> (2 m × 2 m) for ease of monitoring. A 0.3 m bound space separated each plot. The crop spacing was 0.2 m × 0.3 m, 0.3 m × 0.3 m, and 0.3 m × 0.4 m, respectively, for the row-to-row and plant-to-plant distance. The data collected were statistically analysed. The height of the faro 44 variety of rice ranged between 35.50 cm to 44.00 cm for plots with 2 tillers per hill, while that of 4 and 6 tillers per hill ranged between 35.50 cm to 41.40 cm and 35.50 cm to 39.30 cm, respectively. Minimum damage of 2.32% was seen for plant hills of 2 tillers, while 9.21% and 11.89% were observed for tillers of 4 and 6, respectively. It was seen that plots with the highest spacing of 30 × 40 cm and tillers of 2 per hill were observed to perform better than those of the other plots within the experimental pots. Such plots had a maximum plant tiller of 37 when counted, with the height of the plants reaching 44 cm after 70 days of planting. In conclusion, farmers within the study area of the Kanko community in Niger State. Nigeria appears not to have any known knowledge of the soil they are cultivating and the water they use as a source of irrigation within the farming areas. It was further concluded that the rice crops would be produced maximally with minimal water application to the rice field.展开更多
Background:Long non-coding RNA(lncRNA)actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1)functions as a competing endogenous RNA to regulate target genes expression by sponging microRNAs(miRs)to play cancer...Background:Long non-coding RNA(lncRNA)actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1)functions as a competing endogenous RNA to regulate target genes expression by sponging microRNAs(miRs)to play cancer-promoting roles in cancer stem cells.However,the regulatory mechanism of AFAP1-AS1 in cervical cancer(CC)stem cells is unknown.The present study aimed to provide a new therapeutic target for the clinical treatment of CC.Methods:Hyaluronic acid receptor cluster of differentiation 44 variant exon 6(CD44v6)(+)CC cells were isolated by flow cytometry(FCM).Small interfering RNAs of AFAP1-AS1(siAFAP1-AS1)were transfected into the(CD44v6)(+)cells.The levels of AFAP1-AS1 were measured by quantitative real-time PCR(qRT-PCR).Sphere formation assay,cell cycle analysis,and Western blotting were used to detect the effect of siAFAP1-AS1.RNA pull-down and luciferase reporter assay were used to verify the relationship between miR-27b-3p and AFAP1-AS1 or vascular endothelial growth factor(VEGF)-C.Results:CD44v6(+)CCcells had remarkable stemness and a high level ofAFAP1-AS1.However,AFAP1-AS1knockdownwithsiAFAP1-AS1suppressed the cell cycle transitionofG(1)/S phase and inhibited self-renewal ofCD44v6(+)CCcells,the levels of the stemnessmarkers octamer-binding transcription factor 4(OCT4),osteopontin(OPN),and cluster of differentiation 133(CD133),and the epithelialmesenchymal transition(EMT)-related proteins Twist1,matrix metalloprotease(MMP)-9,and VEGF-C.In the mechanism study,miR-27b-3p/VEGF-C signaling was demonstrated to be a key downstream of AFAP1-AS1 in the CD44v6(+)CC cells.Conclusions:LncRNA AFAP1-AS1 knockdown inhibits the CC cell stemness by upregulating miR-27b-3p to suppress VEGF-C.展开更多
Objective： To explore the effects and possible mechanisms of Guiqi Oral Liquid （归芪口服液, GQOL） on the recovery of hematopoiesis in acute irradiation injured mice. Methods： The acute irradiation injured mice wer...Objective： To explore the effects and possible mechanisms of Guiqi Oral Liquid （归芪口服液, GQOL） on the recovery of hematopoiesis in acute irradiation injured mice. Methods： The acute irradiation injured mice were randomly divided into 2 groups： the treated group and the control group, and also a normal control group was set up with 6 mice in it receiving no treatment. After the mice in the former two groups were irradiated by 6.0 Gy ^60Coγ-ray, every one of them was given 0.4 ml GQOL or saline in equal volume through a gastric tube twice a day for 14 days. On the 4th, 8th and 14th day after irradiation, the bone marrow mononuclear cells （BMMNC） and megakaryocytes in bone marrow tissues of the mice were counted, the proportion of hematopoietic tissues （by area） was measured, and the expression of adhesion molecules, CD44 and CD54, in bone marrow were estimated by immunochemistry. The colony forming unit of spleen （CFU-S） in the mice were counted on the 8th day after irradiation. Results： On the 4th, 8th, 14th day after irradiation, the count of BMMNC and megakaryocyte, and the proportion of hematopoietic tissues in the treated group were higher than those in the control group （P〈0.01 or P〈0.05）. CD44 and CD54 expression in the treated group were higher than those in the control group on the 4th and 8th day （P〈0.01）, but near normal on the 14th day （P〈0.01）. On the 8th day, CFU-S count in the treated group was higher than that in the control group （P〈0.01）. Conclusion： GQOL can regulate the expression of adhesion molecules, CD44 and CD54, in the bone marrow of the acute irradiation injured mice, which may be one of the mechanisms of GQOL in accelerating the early phase hematopoiesis recovery of mice.展开更多
Among the large energy storage batteries,the sodium ion batteries(SIBs)are attracted huge interest due to the fact of its abundant raw materials and low cost,and has become the most promising secondary battery.Tunnel-...Among the large energy storage batteries,the sodium ion batteries(SIBs)are attracted huge interest due to the fact of its abundant raw materials and low cost,and has become the most promising secondary battery.Tunnel-type sodium manganese oxides(TMOs)are industrialized cathode materials because of their simple synthesis method and proficient electrochemical performance.Na_(0.44)MnO_(2)(NMO)is considered the best candidate material for all tunnel-type structural materials.In this paper,the research progress in charge and discharge of cathode materials for tunnel-type structural SIBs is reviewed,the redox mechanism and all sorts of synthesis methods and different coating methods lead to different morphology and electrochemical properties of materials and the classification of electrolytes and nonaqueous electrolytes.The development and utility of aqueous solutions are discussed,and the mechanism is analyzed.Summarized the cationic potential of the transition metal oxide for tunnel structure,plays a vital role in predicting and designing the cathode material of this structure.In addition,the future opportunities and challenges for such tunnel-type SIBs in this field are described in detail.展开更多
We report on the properties of strong pulses from PSR B0656＋14 by analyzing the data obtained using the Urumqi 25-m radio telescope at 1540 MHz from August 2007 to September 2010.In 44 h of observational data,a total...We report on the properties of strong pulses from PSR B0656＋14 by analyzing the data obtained using the Urumqi 25-m radio telescope at 1540 MHz from August 2007 to September 2010.In 44 h of observational data,a total of 67 pulses with signal-to-noise ratios above a 5σthreshold were detected.The peak flux densities of these pulses are 58 to 194 times that of the average profile,and their pulse energies are 3 to 68 times that of the average pulse.These pulses are clustered around phases about 5-ahead of the peak of the average profile.Compared with the width of the average profile,they are relatively narrow,with the full widths at half-maximum ranging from 0.28 ° to 1.78 °.The distribution of pulse-energies follows a lognormal distribution.These sporadic strong pulses detected from PSR B0656＋14 have different characteristics from both typical giant pulses and its regular pulses.展开更多
To investigate the expression of cluster of differentiation 44 variant 6 (CD 44V6 ) and proliferating cell nuclear antigen (PCNA) in ocular squamous cell carcinomas Methods Streptavidin biotin complex (SABC) i...To investigate the expression of cluster of differentiation 44 variant 6 (CD 44V6 ) and proliferating cell nuclear antigen (PCNA) in ocular squamous cell carcinomas Methods Streptavidin biotin complex (SABC) immunohistochemistry was used to explore the expression of CD 44V6 and PCNA in 35 cases of ocular squamous cell carcinomas, 20 cases of papillomas, and 11 cases of normal eyelid tissue Results The CD 44V6 positive rate was 62 9% (22/35) in ocular squamous cell carcinomas, 15 0% (3/20) in papillomas, but not detectable in the 11 cases of normal eyelid tissue The positive expression rates of CD 44V6 in ocular squamous cell carcinomas were significantly higher than in benign tumors (χ 2=11 57, P 【0 01)or control tissue ( P =0 001), and the positive expression rates of CD 44V6 in metastasis were significantly higher than without metastasis ( P =0 049) PCNA labeling indexes (PI) in tumors with CD 44V6 expression were significantly higher than those without ( t =20 21, P 【0 01) Conclusions Overexpression of CD 44V6 is correlated with the progress and metastasis of ocular squamous cell carcinomas CD 44V6 protein positive staining is associated with high PI CD 44V6 and PCNA are useful for evaluating prognosis展开更多
Ankylosing spondylitis (AS) is a rare inflammatory disorder that affects the axial skeleton. It is characterized by inflammation of the joints of the spine with subsequent bridging of the spinal segments resulting in ...Ankylosing spondylitis (AS) is a rare inflammatory disorder that affects the axial skeleton. It is characterized by inflammation of the joints of the spine with subsequent bridging of the spinal segments resulting in a reduced mobility of the spine and subsequent stiffness of the spine. It can be a severely limiting condition adversely affecting the quality of life of affected individuals. It has been found to be commoner in Caucasians and Asians but rare in blacks in the Americas with few cases reported amongst the African Black population. It is associated with the occurrence of the major histocompatibility complex (MHC) class 1 allele HLA-B27. We present the case of a 44-year-old Nigerian man presenting with a 21-year history of progressively worsening back pain and stiffness associated with hip pain and difficulty in extending his neck. He had no extraspinal manifestations. He was diagnosed with Ankylosing Spondylitis using the modified New York criteria. He was commenced on selective COX2 inhibitors and a physical therapy program aimed at improving the flexibility of the spine and reducing pain. He had a significant improvement in his pain and improved flexibility of his spine in all planes. Ankylosing spondylitis affects the axial skeleton primarily but there may be some extra spinal manifestations such as anterior uveitis, psoriasis and inflammatory bowel disease. Various modalities are employed in its treatment ranging from physical therapy, drugs e.g. Nonsteroidal anti-inflammatory drugs, tumour necrosis factor inbibitors and surgery where complications arise. These have proven effective in improving the symptoms of the disease and quality of life.展开更多
基金Supported by A research grant offered by Mashhad University of Medical Sciences, No. 85017
文摘AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients.
文摘This study aimed to explore the molecular mechanism in tumor invasion and metastasis. The expression of matrix metalloproteinase 2, 9 (MMP 2, MMP 9), tissue inhibitor 1 of matrix metalloproteinase (TIMP 1), cell adhesion molecule 44 variant 6 (CD44v6), HER2/neu and p53 was investigated in 154 patients with head and neck squamous cell carcinoma (SCC) by ABC and ImmunoMax immunohistochemical method. Their clinical relevance and correlation were analysed. The expression of MMP 2, MMP 9, TIMP 1, CD44v6, HER2/neu and p53 was found in cancer cells in 87.01%, 85.71%, 68.18%, 98.05%, 55.19% and 50.65% cases respectively. Linear regression and correlation analysis revealed that there was close positive relationship ( P <0.05) between the expression of MMP 2 and MMP 9, TIMP 1 and CD44v6, HER2/neu and MMP 9, MMP 2 and p53. Up regulation of MMP 2 was accompanied by advanced T stage ( P <0.01) . There was also a trend of MMP 2 expression being related with tumor metastasis. Increased expression of HER2/neu was found in patients with tumor recurrence( P <0.05). The expression of TIMP 1 was higher in laryngeal cancer than that in pharyngeal cancer, and higher in keratinizing and non keratinizing SCC than that in basaloid SCC( P <0.05). These findings suggested that MMP 2 and MMP 9, HER2/neu and MMP 9, MMP 2 and p53 had a coordinate function in aggression of tumor; that MMP 2 had a more important function than MMP 9 in tumor invasion and metastasis; and that HER2/neu might serve as a biomarker for poor prognosis in HNSCC.
基金supported by a grant from the National Key Basic Research and Development Project(973 Program),No.2012CB518504a grant from the National Level Undergraduate Student Innovation Venture Training Project of Local Colleges,No.201212121048a grant from the ThreeStage Key Subject Construction Project of Guangdong Province of China(211 Project),No.(2009)431
文摘Acupuncture can induce changes in the brain. However, the majority of studies to date have focused on a single acupoint at a time. In the present study, we observed activity changes in the brains of healthy volunteers before and after acupuncture atTaichong （LR3） andTaixi （KI3） using resting-state functional magnetic resonance imaging. Fifteen healthy volunteers underwent resting-state functional magnetic resonance imaging of the brain 15 minutes before acupuncture, then received acupuncture atTaichong andTaixi using the nail-pressing needle insertion method, after which the needle was retained in place for 30 minutes. Fifteen minutes after withdrawal of the needle, the volunteers underwent a further session of resting-state functional magnetic res-onance imaging, which revealed that the amplitude of low-frequency lfuctuation, a measure of spontaneous neuronal activity, increased mainly in the cerebral occipital lobe and middle occipital gyrus （Brodmann area 18/19）, inferior occipital gyrus （Brodmann area 18） and cuneus （Brodmann area 18）, but decreased mainly in the gyrus rectus of the frontal lobe （Brodmann area 11）, inferi-or frontal gyrus （Brodmann area 44） and the center of the posterior lobe of the cerebellum. The present ifndings indicate that acupuncture atTaichong andTaixi speciifcally promote blood lfow and activation in the brain areas related to vision, emotion and cognition, and inhibit brain areas related to emotion, attention, phonological and semantic processing, and memory.
文摘Water and land are the necessary agricultural inputs, and both are scarce these days. This study aims to determine the effect of water application rate on selected planting and crop parameters of Farro 44 rice during dry season farming and its growth response. The randomised complete block design was employed for the Farro 44 rice variety, with each plot size 4 m<sup>2</sup> (2 m × 2 m) for ease of monitoring. A 0.3 m bound space separated each plot. The crop spacing was 0.2 m × 0.3 m, 0.3 m × 0.3 m, and 0.3 m × 0.4 m, respectively, for the row-to-row and plant-to-plant distance. The data collected were statistically analysed. The height of the faro 44 variety of rice ranged between 35.50 cm to 44.00 cm for plots with 2 tillers per hill, while that of 4 and 6 tillers per hill ranged between 35.50 cm to 41.40 cm and 35.50 cm to 39.30 cm, respectively. Minimum damage of 2.32% was seen for plant hills of 2 tillers, while 9.21% and 11.89% were observed for tillers of 4 and 6, respectively. It was seen that plots with the highest spacing of 30 × 40 cm and tillers of 2 per hill were observed to perform better than those of the other plots within the experimental pots. Such plots had a maximum plant tiller of 37 when counted, with the height of the plants reaching 44 cm after 70 days of planting. In conclusion, farmers within the study area of the Kanko community in Niger State. Nigeria appears not to have any known knowledge of the soil they are cultivating and the water they use as a source of irrigation within the farming areas. It was further concluded that the rice crops would be produced maximally with minimal water application to the rice field.
文摘Background:Long non-coding RNA(lncRNA)actin filament-associated protein 1 antisense RNA 1(AFAP1-AS1)functions as a competing endogenous RNA to regulate target genes expression by sponging microRNAs(miRs)to play cancer-promoting roles in cancer stem cells.However,the regulatory mechanism of AFAP1-AS1 in cervical cancer(CC)stem cells is unknown.The present study aimed to provide a new therapeutic target for the clinical treatment of CC.Methods:Hyaluronic acid receptor cluster of differentiation 44 variant exon 6(CD44v6)(+)CC cells were isolated by flow cytometry(FCM).Small interfering RNAs of AFAP1-AS1(siAFAP1-AS1)were transfected into the(CD44v6)(+)cells.The levels of AFAP1-AS1 were measured by quantitative real-time PCR(qRT-PCR).Sphere formation assay,cell cycle analysis,and Western blotting were used to detect the effect of siAFAP1-AS1.RNA pull-down and luciferase reporter assay were used to verify the relationship between miR-27b-3p and AFAP1-AS1 or vascular endothelial growth factor(VEGF)-C.Results:CD44v6(+)CCcells had remarkable stemness and a high level ofAFAP1-AS1.However,AFAP1-AS1knockdownwithsiAFAP1-AS1suppressed the cell cycle transitionofG(1)/S phase and inhibited self-renewal ofCD44v6(+)CCcells,the levels of the stemnessmarkers octamer-binding transcription factor 4(OCT4),osteopontin(OPN),and cluster of differentiation 133(CD133),and the epithelialmesenchymal transition(EMT)-related proteins Twist1,matrix metalloprotease(MMP)-9,and VEGF-C.In the mechanism study,miR-27b-3p/VEGF-C signaling was demonstrated to be a key downstream of AFAP1-AS1 in the CD44v6(+)CC cells.Conclusions:LncRNA AFAP1-AS1 knockdown inhibits the CC cell stemness by upregulating miR-27b-3p to suppress VEGF-C.
基金Supported by the National Natural Science Foundation ofChina (No .39870926)
文摘Objective： To explore the effects and possible mechanisms of Guiqi Oral Liquid （归芪口服液, GQOL） on the recovery of hematopoiesis in acute irradiation injured mice. Methods： The acute irradiation injured mice were randomly divided into 2 groups： the treated group and the control group, and also a normal control group was set up with 6 mice in it receiving no treatment. After the mice in the former two groups were irradiated by 6.0 Gy ^60Coγ-ray, every one of them was given 0.4 ml GQOL or saline in equal volume through a gastric tube twice a day for 14 days. On the 4th, 8th and 14th day after irradiation, the bone marrow mononuclear cells （BMMNC） and megakaryocytes in bone marrow tissues of the mice were counted, the proportion of hematopoietic tissues （by area） was measured, and the expression of adhesion molecules, CD44 and CD54, in bone marrow were estimated by immunochemistry. The colony forming unit of spleen （CFU-S） in the mice were counted on the 8th day after irradiation. Results： On the 4th, 8th, 14th day after irradiation, the count of BMMNC and megakaryocyte, and the proportion of hematopoietic tissues in the treated group were higher than those in the control group （P〈0.01 or P〈0.05）. CD44 and CD54 expression in the treated group were higher than those in the control group on the 4th and 8th day （P〈0.01）, but near normal on the 14th day （P〈0.01）. On the 8th day, CFU-S count in the treated group was higher than that in the control group （P〈0.01）. Conclusion： GQOL can regulate the expression of adhesion molecules, CD44 and CD54, in the bone marrow of the acute irradiation injured mice, which may be one of the mechanisms of GQOL in accelerating the early phase hematopoiesis recovery of mice.
基金supported by the National Natural Science Foundation of China (NSFC, Nos. 51804035, 51874079 and 51674068the Hebei Province Key Research and Development Plan Project (No.19211302D)+2 种基金the support from Natural Science Foundation of Hebei Province (No. E2018501091)The Fundamental Research Funds for the Central Universities (Nos. N172302001, N182306001, N182312007, N2023040)the support from Research Project on the Distribution of Heavy Metals in Soil and Comprehensive Utilization Technology of Tailings in Typical Iron Tailing Reservoir Areas of Hebei Province (No. 802060671901)
文摘Among the large energy storage batteries,the sodium ion batteries(SIBs)are attracted huge interest due to the fact of its abundant raw materials and low cost,and has become the most promising secondary battery.Tunnel-type sodium manganese oxides(TMOs)are industrialized cathode materials because of their simple synthesis method and proficient electrochemical performance.Na_(0.44)MnO_(2)(NMO)is considered the best candidate material for all tunnel-type structural materials.In this paper,the research progress in charge and discharge of cathode materials for tunnel-type structural SIBs is reviewed,the redox mechanism and all sorts of synthesis methods and different coating methods lead to different morphology and electrochemical properties of materials and the classification of electrolytes and nonaqueous electrolytes.The development and utility of aqueous solutions are discussed,and the mechanism is analyzed.Summarized the cationic potential of the transition metal oxide for tunnel structure,plays a vital role in predicting and designing the cathode material of this structure.In addition,the future opportunities and challenges for such tunnel-type SIBs in this field are described in detail.
基金funded by the National Natural Science Foundation of China(Grant No.10973026)
文摘We report on the properties of strong pulses from PSR B0656＋14 by analyzing the data obtained using the Urumqi 25-m radio telescope at 1540 MHz from August 2007 to September 2010.In 44 h of observational data,a total of 67 pulses with signal-to-noise ratios above a 5σthreshold were detected.The peak flux densities of these pulses are 58 to 194 times that of the average profile,and their pulse energies are 3 to 68 times that of the average pulse.These pulses are clustered around phases about 5-ahead of the peak of the average profile.Compared with the width of the average profile,they are relatively narrow,with the full widths at half-maximum ranging from 0.28 ° to 1.78 °.The distribution of pulse-energies follows a lognormal distribution.These sporadic strong pulses detected from PSR B0656＋14 have different characteristics from both typical giant pulses and its regular pulses.
文摘To investigate the expression of cluster of differentiation 44 variant 6 (CD 44V6 ) and proliferating cell nuclear antigen (PCNA) in ocular squamous cell carcinomas Methods Streptavidin biotin complex (SABC) immunohistochemistry was used to explore the expression of CD 44V6 and PCNA in 35 cases of ocular squamous cell carcinomas, 20 cases of papillomas, and 11 cases of normal eyelid tissue Results The CD 44V6 positive rate was 62 9% (22/35) in ocular squamous cell carcinomas, 15 0% (3/20) in papillomas, but not detectable in the 11 cases of normal eyelid tissue The positive expression rates of CD 44V6 in ocular squamous cell carcinomas were significantly higher than in benign tumors (χ 2=11 57, P 【0 01)or control tissue ( P =0 001), and the positive expression rates of CD 44V6 in metastasis were significantly higher than without metastasis ( P =0 049) PCNA labeling indexes (PI) in tumors with CD 44V6 expression were significantly higher than those without ( t =20 21, P 【0 01) Conclusions Overexpression of CD 44V6 is correlated with the progress and metastasis of ocular squamous cell carcinomas CD 44V6 protein positive staining is associated with high PI CD 44V6 and PCNA are useful for evaluating prognosis
文摘Ankylosing spondylitis (AS) is a rare inflammatory disorder that affects the axial skeleton. It is characterized by inflammation of the joints of the spine with subsequent bridging of the spinal segments resulting in a reduced mobility of the spine and subsequent stiffness of the spine. It can be a severely limiting condition adversely affecting the quality of life of affected individuals. It has been found to be commoner in Caucasians and Asians but rare in blacks in the Americas with few cases reported amongst the African Black population. It is associated with the occurrence of the major histocompatibility complex (MHC) class 1 allele HLA-B27. We present the case of a 44-year-old Nigerian man presenting with a 21-year history of progressively worsening back pain and stiffness associated with hip pain and difficulty in extending his neck. He had no extraspinal manifestations. He was diagnosed with Ankylosing Spondylitis using the modified New York criteria. He was commenced on selective COX2 inhibitors and a physical therapy program aimed at improving the flexibility of the spine and reducing pain. He had a significant improvement in his pain and improved flexibility of his spine in all planes. Ankylosing spondylitis affects the axial skeleton primarily but there may be some extra spinal manifestations such as anterior uveitis, psoriasis and inflammatory bowel disease. Various modalities are employed in its treatment ranging from physical therapy, drugs e.g. Nonsteroidal anti-inflammatory drugs, tumour necrosis factor inbibitors and surgery where complications arise. These have proven effective in improving the symptoms of the disease and quality of life.
