Probiotical cell fragments (PCFs) are structural components of the probiotic cell lysate(s) and exhibit similar beneficial effects on the host as live probiotic bacteria. With cell fragment technology (CFT?), the stru...Probiotical cell fragments (PCFs) are structural components of the probiotic cell lysate(s) and exhibit similar beneficial effects on the host as live probiotic bacteria. With cell fragment technology (CFT?), the structural fragments are isolated and purified from live probiotic cells. While observed to be strain-dependent as in the case of live probiotics, orally administered PCFs demonstrated a broad spectrum of immune modulation functions;anti-allergy;anti-inflammation;anti-bacterial and anti-viral properties;anti-mutagenic;and radioprotective and detoxification abilities in humans and animals. The PCFs mechanisms of action include events of motifs of cell wall peptidoglycans, DNA motifs, nucleotide containing components, lipoteichoic acids (LPAs), surface layer (S-layer) proteins, and cytoplasmic proteins. Different immunological in vivo-in vitro tests have shown that PCFs, essentially, have the ability to stimulate the macrophages, and induce cytokines such as interleukins, tumor necrosis factors (TNFs), interferons (IFNs), and natural killer (NK) cells. PCFs may be used as ingredients for foods and beverages or as nutritional supplements with long term stability and shelf-life up to 5 years. PCFs may also be used as health restorative ingredients in cosmetic products. The outcome of probiotics CFT? stands as an advantage to the food and pharmaceutical industries, regarding the formulation of novel products with unadulterated sensory characteristics of origin. Hence, PCFs are being characterized here as “novel nutraceutical ingredients” for health maintenance in both humans and animals.展开更多
We propose broad supercontinuum spectrum generating highly nonlinear photonic crystal fiber (HN-PCF) which can be used in ultrahigh- resolution optical coherence tomography and optical transmission systems. Using full...We propose broad supercontinuum spectrum generating highly nonlinear photonic crystal fiber (HN-PCF) which can be used in ultrahigh- resolution optical coherence tomography and optical transmission systems. Using full vector finite difference method, we investigated the different properties of HN-PCF. Broadband su-percontinuum spectrum is numerically calculated by using nonlinear Schr?dinger equation. Investigation showed that it is possible to obtain longitudinal resolution in a biological tissue of 1.3 μm, 1.2 μm and 1.1 μm by using picosecond continuum light at center wavelengths of 1.06 μm, 1.31 μm and 1.55 μm, respectively.展开更多
Objective： To investigate the existence of pericryptal fibroblasts sheath （PCFS） in normal gastric mucosa, intestinal metaplasia （IM）, indefinite for dysplasia （I-Dys）, low grade dysplasia （L-Dys）, high grade...Objective： To investigate the existence of pericryptal fibroblasts sheath （PCFS） in normal gastric mucosa, intestinal metaplasia （IM）, indefinite for dysplasia （I-Dys）, low grade dysplasia （L-Dys）, high grade dysplasia （H-Dys） and gastric cancer （GC）, and its association with gastric carcinogenesis. Methods： In this study, we examined the existence of PCFS in normal gastric mucosa （N=10）, IM （N=26）, I-Dys （N=16）, L-Dys （N=13）, H-Dys （N=21） and GC （N=145） using immunohistochemical staining for two smooth muscle markers, alpha smooth muscle actin（α-SMA） and high molecular weight caldesmon （h-CD）. The significance of PCFS was discussed, especially in association with gastric carcinogenesis. Results： The PCFS was recognized in 65.4%（17/26） of IM, 62.5%（10/16） of I-Dys and 23.1% （3/13） of L-Dys respectively. No PCFS was detected in H-Dys and GC. The PCFS was gradually reduced in IM, Dys and GC in sequence （P〈0.0001）. Conclusion： The PCFS is associated with the differentiation of epithelium and involved in gastric carcinogenesis via epithelial-mesenchymal interaction.展开更多
Liquid crystal photonic bandgap （LCPBG） fibers provide a versatile and robust platform for designing optical fiber devices, which are highly tunable and exhibit novel optical properties for manipulation of guided li...Liquid crystal photonic bandgap （LCPBG） fibers provide a versatile and robust platform for designing optical fiber devices, which are highly tunable and exhibit novel optical properties for manipulation of guided light. We review the research progress on design, fabrication and development of integrated LCPBG fiber devices.展开更多
Using a full-vector finite-difference time-domain （FDTD） method, this article explores the propagation characteristics of photonic crystal fiber （PCF） theoretically. The dependence of structural parameters on the ...Using a full-vector finite-difference time-domain （FDTD） method, this article explores the propagation characteristics of photonic crystal fiber （PCF） theoretically. The dependence of structural parameters on the effective index of the fundamental guided mode, effective index of the fundamental cladding mode, mode field diameter, confinement loss, effective mode area, and chromatic dispersion in PCF have been studied, respectively. The research presents a reference for designing of PCF with a specific purpose.展开更多
Photonic crystal fibers (PCFs) with anomalous dispersion in short wavelength region are significant for some applications, such as short wavelength soliton propagation, super continuum generation and short pulse fiber...Photonic crystal fibers (PCFs) with anomalous dispersion in short wavelength region are significant for some applications, such as short wavelength soliton propagation, super continuum generation and short pulse fiber lasing.In this paper,a systematic method for designing PCFs with required anomalous dispersion region is proposed by using a finite difference solver and the scaling transformation of the waveguide dispersion of PCFs.Designed PCF can be anomalously dispersive in the region less than 1.3 μm,which is very difficult to realize in the traditional standard single-mode fibers.The effectiveness of the proposed method is approved by numerical results.展开更多
As a new type optical fiber,because of its particular optical properties,photonic crystal fibers(PCFs) have attracted the academic and industrial field widespread attention.So,the researches about PCFs have made great...As a new type optical fiber,because of its particular optical properties,photonic crystal fibers(PCFs) have attracted the academic and industrial field widespread attention.So,the researches about PCFs have made great progress in recent decade.In this paper,two kinds of PCFs constructions are numerically investigated and its leakage-loss properties are simulated.Based on the results of calculations,both the two types of PCFs are fabricated using glass capillary tube stacking.And the process of fiber drawing is described in this paper.展开更多
文摘Probiotical cell fragments (PCFs) are structural components of the probiotic cell lysate(s) and exhibit similar beneficial effects on the host as live probiotic bacteria. With cell fragment technology (CFT?), the structural fragments are isolated and purified from live probiotic cells. While observed to be strain-dependent as in the case of live probiotics, orally administered PCFs demonstrated a broad spectrum of immune modulation functions;anti-allergy;anti-inflammation;anti-bacterial and anti-viral properties;anti-mutagenic;and radioprotective and detoxification abilities in humans and animals. The PCFs mechanisms of action include events of motifs of cell wall peptidoglycans, DNA motifs, nucleotide containing components, lipoteichoic acids (LPAs), surface layer (S-layer) proteins, and cytoplasmic proteins. Different immunological in vivo-in vitro tests have shown that PCFs, essentially, have the ability to stimulate the macrophages, and induce cytokines such as interleukins, tumor necrosis factors (TNFs), interferons (IFNs), and natural killer (NK) cells. PCFs may be used as ingredients for foods and beverages or as nutritional supplements with long term stability and shelf-life up to 5 years. PCFs may also be used as health restorative ingredients in cosmetic products. The outcome of probiotics CFT? stands as an advantage to the food and pharmaceutical industries, regarding the formulation of novel products with unadulterated sensory characteristics of origin. Hence, PCFs are being characterized here as “novel nutraceutical ingredients” for health maintenance in both humans and animals.
文摘We propose broad supercontinuum spectrum generating highly nonlinear photonic crystal fiber (HN-PCF) which can be used in ultrahigh- resolution optical coherence tomography and optical transmission systems. Using full vector finite difference method, we investigated the different properties of HN-PCF. Broadband su-percontinuum spectrum is numerically calculated by using nonlinear Schr?dinger equation. Investigation showed that it is possible to obtain longitudinal resolution in a biological tissue of 1.3 μm, 1.2 μm and 1.1 μm by using picosecond continuum light at center wavelengths of 1.06 μm, 1.31 μm and 1.55 μm, respectively.
基金supported in part by the grants from Beijing Municipal Science & Technology commission NOVA program (No.2005B-44)the National"863"High-Tech Res & Dev program of China(No.2006AA02A402)the Major State Basic Research Program of china(No.2004CB518702)
文摘Objective： To investigate the existence of pericryptal fibroblasts sheath （PCFS） in normal gastric mucosa, intestinal metaplasia （IM）, indefinite for dysplasia （I-Dys）, low grade dysplasia （L-Dys）, high grade dysplasia （H-Dys） and gastric cancer （GC）, and its association with gastric carcinogenesis. Methods： In this study, we examined the existence of PCFS in normal gastric mucosa （N=10）, IM （N=26）, I-Dys （N=16）, L-Dys （N=13）, H-Dys （N=21） and GC （N=145） using immunohistochemical staining for two smooth muscle markers, alpha smooth muscle actin（α-SMA） and high molecular weight caldesmon （h-CD）. The significance of PCFS was discussed, especially in association with gastric carcinogenesis. Results： The PCFS was recognized in 65.4%（17/26） of IM, 62.5%（10/16） of I-Dys and 23.1% （3/13） of L-Dys respectively. No PCFS was detected in H-Dys and GC. The PCFS was gradually reduced in IM, Dys and GC in sequence （P〈0.0001）. Conclusion： The PCFS is associated with the differentiation of epithelium and involved in gastric carcinogenesis via epithelial-mesenchymal interaction.
文摘Liquid crystal photonic bandgap （LCPBG） fibers provide a versatile and robust platform for designing optical fiber devices, which are highly tunable and exhibit novel optical properties for manipulation of guided light. We review the research progress on design, fabrication and development of integrated LCPBG fiber devices.
基金supported by the National Natural Science Foundation of China(60644004)the National Basic Research Program of China(2003CB314901)
文摘Using a full-vector finite-difference time-domain （FDTD） method, this article explores the propagation characteristics of photonic crystal fiber （PCF） theoretically. The dependence of structural parameters on the effective index of the fundamental guided mode, effective index of the fundamental cladding mode, mode field diameter, confinement loss, effective mode area, and chromatic dispersion in PCF have been studied, respectively. The research presents a reference for designing of PCF with a specific purpose.
基金This work was supported by National Natural Science Foundationof China(No.60407011 and No.60277018)Zhejiang Provin-cial Natural Science Foundation of China (No.Y104073)
文摘Photonic crystal fibers (PCFs) with anomalous dispersion in short wavelength region are significant for some applications, such as short wavelength soliton propagation, super continuum generation and short pulse fiber lasing.In this paper,a systematic method for designing PCFs with required anomalous dispersion region is proposed by using a finite difference solver and the scaling transformation of the waveguide dispersion of PCFs.Designed PCF can be anomalously dispersive in the region less than 1.3 μm,which is very difficult to realize in the traditional standard single-mode fibers.The effectiveness of the proposed method is approved by numerical results.
文摘As a new type optical fiber,because of its particular optical properties,photonic crystal fibers(PCFs) have attracted the academic and industrial field widespread attention.So,the researches about PCFs have made great progress in recent decade.In this paper,two kinds of PCFs constructions are numerically investigated and its leakage-loss properties are simulated.Based on the results of calculations,both the two types of PCFs are fabricated using glass capillary tube stacking.And the process of fiber drawing is described in this paper.
