Natural killer (NK) cells have the ability to mediate both bone marrow rejection and promote engraftment,as well as the ability to elicit potent anti-tumor effects.However the clinical results for these processes are ...Natural killer (NK) cells have the ability to mediate both bone marrow rejection and promote engraftment,as well as the ability to elicit potent anti-tumor effects.However the clinical results for these processes are still elusive.Greater understanding of NK cell biology,from activating and inhibitory receptor functions to the role of NK cells in allogeneic transplantation,needs to be appreciated in order to draw out the clinical potential of NK cells.Mechanisms of bone marrow cell (BMC) rejection are known to be dependant on inhibitory receptors specific for major histocompatibility complex (MHC) molecules and on activating receptors that have many potential ligands.The modulation of activating and inhibitory receptors may hold the key to clinical success involving NK cells.Pre-clinical studies in mice have shown that different combinations of activating and inhibitory receptors on NK cells can reduce graft-versus-host disease (GVHD),promote engraftment,and provide superior graft-versus-tumor (GVT) responses.Recent clinical data have shown that the use of KIR-ligand incompatibility produces tremendous graft-versus-leukemia effect in patients with acute myeloid leukemia at high risk of relapse.This review will attempt to be a synthesis of current knowledge concerning NK cells,their involvement in BMT,and their use as an immunotherapy for cancer and other hematologic malignancies.Cellular & Molecular Immunology.2004;1(1):12-21.展开更多
After the rats were inflicted with 8 Gy total body gamma ray irradiation and 15 % total body surface area (TBSA) full thickness burn injury, they were treated with blood transfusion (BT) and bone marrow transplantatio...After the rats were inflicted with 8 Gy total body gamma ray irradiation and 15 % total body surface area (TBSA) full thickness burn injury, they were treated with blood transfusion (BT) and bone marrow transplantation (BMT). Then the survival of allografts grafted on the escharectomized burn wounds in the 24, 48 and 72 h postinjury was observed. It was found that when the burn wounds were closed with allo- grafts in the 24h postinjury, there were an early elevation of leucocytes, the appearance of the donor’s cells and a significantly higher survival rate of the rats on the 30 day postinjury. The allografts could survive longer and wounds showed no signs of infection and healed quicker. When the allografts were grafted in the 48 h or 72 h postinjury, only harmful effects to hasten the death of rats were observed.展开更多
文摘Natural killer (NK) cells have the ability to mediate both bone marrow rejection and promote engraftment,as well as the ability to elicit potent anti-tumor effects.However the clinical results for these processes are still elusive.Greater understanding of NK cell biology,from activating and inhibitory receptor functions to the role of NK cells in allogeneic transplantation,needs to be appreciated in order to draw out the clinical potential of NK cells.Mechanisms of bone marrow cell (BMC) rejection are known to be dependant on inhibitory receptors specific for major histocompatibility complex (MHC) molecules and on activating receptors that have many potential ligands.The modulation of activating and inhibitory receptors may hold the key to clinical success involving NK cells.Pre-clinical studies in mice have shown that different combinations of activating and inhibitory receptors on NK cells can reduce graft-versus-host disease (GVHD),promote engraftment,and provide superior graft-versus-tumor (GVT) responses.Recent clinical data have shown that the use of KIR-ligand incompatibility produces tremendous graft-versus-leukemia effect in patients with acute myeloid leukemia at high risk of relapse.This review will attempt to be a synthesis of current knowledge concerning NK cells,their involvement in BMT,and their use as an immunotherapy for cancer and other hematologic malignancies.Cellular & Molecular Immunology.2004;1(1):12-21.
文摘After the rats were inflicted with 8 Gy total body gamma ray irradiation and 15 % total body surface area (TBSA) full thickness burn injury, they were treated with blood transfusion (BT) and bone marrow transplantation (BMT). Then the survival of allografts grafted on the escharectomized burn wounds in the 24, 48 and 72 h postinjury was observed. It was found that when the burn wounds were closed with allo- grafts in the 24h postinjury, there were an early elevation of leucocytes, the appearance of the donor’s cells and a significantly higher survival rate of the rats on the 30 day postinjury. The allografts could survive longer and wounds showed no signs of infection and healed quicker. When the allografts were grafted in the 48 h or 72 h postinjury, only harmful effects to hasten the death of rats were observed.
