Neuropathic pain remains one of the most difficult forms of pain to treat.The wide variety of drugs currently used in its treatment often does not provide adequate pain relief.From a clinical point of view,an interact...Neuropathic pain remains one of the most difficult forms of pain to treat.The wide variety of drugs currently used in its treatment often does not provide adequate pain relief.From a clinical point of view,an interaction between of the melanocortin and opioid systems is interesting because administration of melanocortin receptor antagonists may increase the sensitivity for opioids,thus improving the efficacy to adverse effects ratio of opioids in neuropathic pain control.Future research is needed to further elucidate the mechanisms underlying these effects of melanocortin and to see whether the melanocortin MC4 receptor can be a target in the challenge to alleviate neuropathic pain.展开更多
文摘Neuropathic pain remains one of the most difficult forms of pain to treat.The wide variety of drugs currently used in its treatment often does not provide adequate pain relief.From a clinical point of view,an interaction between of the melanocortin and opioid systems is interesting because administration of melanocortin receptor antagonists may increase the sensitivity for opioids,thus improving the efficacy to adverse effects ratio of opioids in neuropathic pain control.Future research is needed to further elucidate the mechanisms underlying these effects of melanocortin and to see whether the melanocortin MC4 receptor can be a target in the challenge to alleviate neuropathic pain.
