Dear Editor,The CRISPR/Cas9（clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9）system is revolutionizing genome editing due to its high efficiency,low cost,design simplicity and ve...Dear Editor,The CRISPR/Cas9（clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9）system is revolutionizing genome editing due to its high efficiency,low cost,design simplicity and versatility.However,introduction of a point mutation at a desired position remains a great challenge in plant genome engineering.展开更多
Precision genome editing tools are invaluable for biology, medicine and agriculture. With these tools we can determine the genetic basis underlying biological traits and processes, and then modify the genome of crops ...Precision genome editing tools are invaluable for biology, medicine and agriculture. With these tools we can determine the genetic basis underlying biological traits and processes, and then modify the genome of crops and livestock, model organisms, and even of patients, for phenotypic improvement, disease modeling and treatment. Site-specific nucleases provide a powerful and effective approach for precise genome editing in organisms.展开更多
基金supported by the National Crop Breeding Fund (2016YFD0101804)National Natural Science Foundation of China (31471785, 31670371)Special Fund for Agro-scientific Research in the Public Interest (201303022)
文摘Dear Editor,The CRISPR/Cas9（clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9）system is revolutionizing genome editing due to its high efficiency,low cost,design simplicity and versatility.However,introduction of a point mutation at a desired position remains a great challenge in plant genome engineering.
文摘Precision genome editing tools are invaluable for biology, medicine and agriculture. With these tools we can determine the genetic basis underlying biological traits and processes, and then modify the genome of crops and livestock, model organisms, and even of patients, for phenotypic improvement, disease modeling and treatment. Site-specific nucleases provide a powerful and effective approach for precise genome editing in organisms.
