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Intravenous pantoprazole versus ranitidine for prevention of rebleeding after endoscopic hemostasis of bleeding peptic ulcers 被引量:4
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作者 Ping-IHsu Gin-HoLo +8 位作者 Ching-ChuLo Chiun-KuLin Hoi-HungChan Chung-JenWu Chang-BihShie Pei-MinTsai Deng-ChyangWu Wen-MingWang Kwok-Hung Lai 《World Journal of Gastroenterology》 SCIE CAS CSCD 2004年第24期3666-3669,共4页
AIM: The role of intravenous pantoprazole in treatment of patients with high-risk bleeding peptic ulcers following endoscopic hemostasis remains uncertain. We therefore conducted the pilot prospective randomized study... AIM: The role of intravenous pantoprazole in treatment of patients with high-risk bleeding peptic ulcers following endoscopic hemostasis remains uncertain. We therefore conducted the pilot prospective randomized study to assess whether intravenous pantoprazole could improve the efficacy of H2-antagonist as an adjunct treatment following endoscopic injection therapy for bleeding ulcers.METHODS: Patients with active bleeding ulcers or ulcers with major signs of recent bleeding were treated with distilled water injection. After hemostasis was achieved, they were randomly assigned to receive intravenous pantoprazole or ranitidine.RESULTS: One hundred and two patients were enrolled in this prospective trial. Bleeding recurred in 2 patients (4%) in the pantoprazole group (n = 52), as compared with 8 (16%) in the ranitidine group (n = 50). The rebleeding rate was significantly lower in the pantoprazole group (P = 0.04).There were no statistically significant differences between the groups with regard to the need for emergency surgery (0% vs2%), transfusion requirements (4.9+5.9 vs5.7:1:6.8 units), hospital days (5.9+3.2 vs7.5:1:5.0 d) or mortality (2% vs 2%).CONCLUSION: Pantoprozole is superior to ranitidine as an adjunct treatment to endoscopic injection therapy in high-risk bleeding ulcers. 展开更多
关键词 静脉疾病 相对作用 雷尼替丁 预防作用 消化性出血 窥镜 止血法 消化性溃疡
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