疼痛是恶性肿瘤患者最常见的症状之一,约80%肿瘤患者在其疾病诊疗过程中会出现癌性疼痛(简称癌痛)[1]。在癌痛患者中,癌性爆发痛(break.through cancer pain,BTcP)的发生率可达33%~95%,BTcP的存在,不仅严重影响患者的日常活动,导致生存...疼痛是恶性肿瘤患者最常见的症状之一,约80%肿瘤患者在其疾病诊疗过程中会出现癌性疼痛(简称癌痛)[1]。在癌痛患者中,癌性爆发痛(break.through cancer pain,BTcP)的发生率可达33%~95%,BTcP的存在,不仅严重影响患者的日常活动,导致生存质量、治疗依从性的下降,还会增加医疗资源的支出[2],而且常常提示临床预后较差且对阿片类药物治疗的抗拒[3]。展开更多
Fentanyl,a synthetic opioid,is a popular choice amongst anesthesiologists because of its intense analgesia,cardiovascular stability and low histamine release.Reflex cough is often observed after an iv bolus of fentany...Fentanyl,a synthetic opioid,is a popular choice amongst anesthesiologists because of its intense analgesia,cardiovascular stability and low histamine release.Reflex cough is often observed after an iv bolus of fentanyl during induction.Yet this phenomenon may be undesirable in patients with some co-existing diseases including increased intracranial pressure,open eye injury,dissecting aortic aneurysm,pneumothorax or reactive airway disease.The purpose of this paper is to review the mechanism,influential factors and prevention of cough reflex induced by fentanyl in recent years.展开更多
文摘疼痛是恶性肿瘤患者最常见的症状之一,约80%肿瘤患者在其疾病诊疗过程中会出现癌性疼痛(简称癌痛)[1]。在癌痛患者中,癌性爆发痛(break.through cancer pain,BTcP)的发生率可达33%~95%,BTcP的存在,不仅严重影响患者的日常活动,导致生存质量、治疗依从性的下降,还会增加医疗资源的支出[2],而且常常提示临床预后较差且对阿片类药物治疗的抗拒[3]。
文摘Fentanyl,a synthetic opioid,is a popular choice amongst anesthesiologists because of its intense analgesia,cardiovascular stability and low histamine release.Reflex cough is often observed after an iv bolus of fentanyl during induction.Yet this phenomenon may be undesirable in patients with some co-existing diseases including increased intracranial pressure,open eye injury,dissecting aortic aneurysm,pneumothorax or reactive airway disease.The purpose of this paper is to review the mechanism,influential factors and prevention of cough reflex induced by fentanyl in recent years.
