To investigate whether terbutaline affects alveolar liquid deorance after oleic acid-induced lung injury in rats. Methods ： Forty healthy Wistor rats （ weighing 250- 280 g） were randomly divided into five groups ...To investigate whether terbutaline affects alveolar liquid deorance after oleic acid-induced lung injury in rats. Methods ： Forty healthy Wistor rats （ weighing 250- 280 g） were randomly divided into five groups （ n = 8 in each group ） ： the normal control group （ control group ）, oleic acid injury group （injury group）, group （terbutaline group ）, terbutaline plus amiloridetreated group （ terbutaline ＋ amiloride group ） and terbutaline plus ouabaln-treated group （terbutaline ＋ ouabaln group）. Acute lung injury model was induced by intravenous oleic acid （0. 25 ml/kg body weight）. 24 hours later, 1.5 μCi^125 I-labeled 5% albumin solution （5 ml/kg body weight） was dripped into the lungs through trachea. The alveolar liquid clearance rate, extravascular lung water content, and arterial blood gas were measured 1 hour thereafter. Results： At24 hours after infusion of oleic acid, the rats developed pulmonary edema and severe hypoxemia,with the alveolar liquid clearance rate decreased by 49. 2 % and the extravascnlar lung water content elevated by 47.9%. Compared with the rats in the injury group, terbutaline （ 10^-4 mol/L ） significantly increased the alveolar liquid clearance rate, decreased the extravascular lung water content and improved hypoxemia. The effect of terlmtaUne was partly blocked by amiloride and ouabain, which were inhibitors of sodium transport. Terbutaline increased the alveolar liquid clearance rate by 63.7 %, and amiloride and ouabain reduced the alveolar liquid clearance rate by 54.7 % and 56. 8 %, respectively. Conclusions： Terbutaline can accelerate alveolar liquid clearance through increasing sodim transport to attenuate pulmonary edema, thus improving gas exchange, which may have therapeutical effect on pulmonary edema after acute lung injury.展开更多
夜间哮喘患者11例,年龄18～58(平均39)岁,用双盲交叉法对慢释放氨茶碱与慢释放间羟舒喘宁的疗效作了比较。试验期间于6.00～9.00 am 及9.00 pm分服外形和数量相同而含上述两种药品的药片,其中氨茶碱为386～900mg/d,(根据病情及原服药量...夜间哮喘患者11例,年龄18～58(平均39)岁,用双盲交叉法对慢释放氨茶碱与慢释放间羟舒喘宁的疗效作了比较。试验期间于6.00～9.00 am 及9.00 pm分服外形和数量相同而含上述两种药品的药片,其中氨茶碱为386～900mg/d,(根据病情及原服药量确定剂量),上午服1/3,晚间服2/3。展开更多
基金This study was supported by the Research Project of the "Tenth Five-year Plan" of PLA (No.01Z074)
文摘To investigate whether terbutaline affects alveolar liquid deorance after oleic acid-induced lung injury in rats. Methods ： Forty healthy Wistor rats （ weighing 250- 280 g） were randomly divided into five groups （ n = 8 in each group ） ： the normal control group （ control group ）, oleic acid injury group （injury group）, group （terbutaline group ）, terbutaline plus amiloridetreated group （ terbutaline ＋ amiloride group ） and terbutaline plus ouabaln-treated group （terbutaline ＋ ouabaln group）. Acute lung injury model was induced by intravenous oleic acid （0. 25 ml/kg body weight）. 24 hours later, 1.5 μCi^125 I-labeled 5% albumin solution （5 ml/kg body weight） was dripped into the lungs through trachea. The alveolar liquid clearance rate, extravascular lung water content, and arterial blood gas were measured 1 hour thereafter. Results： At24 hours after infusion of oleic acid, the rats developed pulmonary edema and severe hypoxemia,with the alveolar liquid clearance rate decreased by 49. 2 % and the extravascnlar lung water content elevated by 47.9%. Compared with the rats in the injury group, terbutaline （ 10^-4 mol/L ） significantly increased the alveolar liquid clearance rate, decreased the extravascular lung water content and improved hypoxemia. The effect of terlmtaUne was partly blocked by amiloride and ouabain, which were inhibitors of sodium transport. Terbutaline increased the alveolar liquid clearance rate by 63.7 %, and amiloride and ouabain reduced the alveolar liquid clearance rate by 54.7 % and 56. 8 %, respectively. Conclusions： Terbutaline can accelerate alveolar liquid clearance through increasing sodim transport to attenuate pulmonary edema, thus improving gas exchange, which may have therapeutical effect on pulmonary edema after acute lung injury.
文摘夜间哮喘患者11例,年龄18～58(平均39)岁,用双盲交叉法对慢释放氨茶碱与慢释放间羟舒喘宁的疗效作了比较。试验期间于6.00～9.00 am 及9.00 pm分服外形和数量相同而含上述两种药品的药片,其中氨茶碱为386～900mg/d,(根据病情及原服药量确定剂量),上午服1/3,晚间服2/3。
