Background -Atherosclerosis has been implicated as a cause of valvular calcification. The aim of this study was to determine whether atherosclerotic calcification in multiple vascular areas is significantly associated...Background -Atherosclerosis has been implicated as a cause of valvular calcification. The aim of this study was to determine whether atherosclerotic calcification in multiple vascular areas is significantly associated with aortic or mitral annular calcification independent of traditional risk factors. Methods and Results -A total of 1242 consecutive asymptomatic patients free of clinical coronary heart disease were studied by electron-beam computed tomography for the extent of calcium due to atherosclerosis in 5 distinct vascular beds and calcium in the aortic and mitral annuli. Nearly 24%had calcium in the aortic annulus, whereas 8%were found to have mitral annular calcification. Age and a history of hypertension were the only traditional cardiovascular risk factors that were independently associated with prevalent calcification in the aortic and mitral annuli. After adjustment for age, gender, and cardiovascular disease risk factors, subjects with calcium in the thoracic aorta had the highest odds for the presence of aortic annular calcium(OR=3.9, P< 0.01), whereas those with calcium in the abdominal aorta had the highest odds for mitral annular calcification(OR=5.1, P=0.01). Standardized increases in calcium in the abdominal aorta(OR=2.0, P< 0.01) and iliacs(OR=1.8, P=0.01) were significantly associated with calcium in the aortic annulus after adjustment for the extent of calcium in the other vascular beds, whereas the thoracic aorta was significantly associated(OR=1.4, P=0.02) with calcium in the mitral annulus. Conclusions -This study supports the hypothesis that calcification of the mitral and aortic annuli is related to atherosclerosis in other vascular beds.展开更多
目的:通过分析钙化性主动脉瓣疾病患者的左室后壁(left ventricle post wall,LVWP)厚度,评价患者瓣膜钙化的严重程度以及预后情况。方法:通过免疫组化染色、光密度半定量分析以及RT-PCR检测分析60例主动脉瓣钙化患者(分为轻、中、重主...目的:通过分析钙化性主动脉瓣疾病患者的左室后壁(left ventricle post wall,LVWP)厚度,评价患者瓣膜钙化的严重程度以及预后情况。方法:通过免疫组化染色、光密度半定量分析以及RT-PCR检测分析60例主动脉瓣钙化患者(分为轻、中、重主动脉瓣狭窄3组)的瓣膜组织钙化程度,比较各患者术前术后的射血分数(ejection fraction,EF)变化值,评估LVWP对判断有无手术指征以及预后的作用。结果:分析不同程度瓣膜狭窄组的LVWP,轻、中、重度瓣膜狭窄组两两对比,LVWP厚度依次增加,差异均有统计学意义。通过对瓣膜组织进行Von Kossa染色后半定量分析以及RT-PCR分析,LVWP轻、中、重度增厚组钙化程度依次加重,差异均有统计学意义。通过对患者手术前后EF差值分析,LVWP中度增厚患者的EF差值比LVWP轻度增厚患者大,差异有统计学意义。LVWP重度增厚患者的EF增加值与LVWP中度增高患者比较,差异无统计学意义。结论:LVWP可以用来预估主动脉瓣瓣膜的钙化程度,对于非主动脉瓣重度钙化患者,LVWP值越大,手术获益也越大。展开更多
目的探讨阻塞性睡眠呼吸暂停(OSA)与急性冠状动脉综合征(ACS)患者冠状血管病变程度的相关性。方法选取2019年5-12月该院心内科收治的ACS住院患者220例,采用Watch PAT 200 TM完成床边睡眠呼吸监测。根据呼吸暂停低通气指数(AHI)分为OSA组...目的探讨阻塞性睡眠呼吸暂停(OSA)与急性冠状动脉综合征(ACS)患者冠状血管病变程度的相关性。方法选取2019年5-12月该院心内科收治的ACS住院患者220例,采用Watch PAT 200 TM完成床边睡眠呼吸监测。根据呼吸暂停低通气指数(AHI)分为OSA组(AHI>15,n=139)和对照组(AHI≤15,n=81)。收集2组患者一般临床资料及睡眠监测资料,分析OSA与ACS患者冠状血管病变程度的相关性。结果OSA组患者体重指数[(25.2±3.3)kg/m^(2)]、钙化半定量积分[(2.7±1.4)分]均明显高于对照组[分别为(24.2±3.2)kg/m^(2)、(2.3±1.4)分],差异均有统计学意义(P<0.05);AHI与冠状动脉钙化半定量积分呈正相关(r=0.142,P=0.035)。结论ACS患者合并OSA所占比例较高,且其冠状血管钙化程度更高。展开更多
文摘Background -Atherosclerosis has been implicated as a cause of valvular calcification. The aim of this study was to determine whether atherosclerotic calcification in multiple vascular areas is significantly associated with aortic or mitral annular calcification independent of traditional risk factors. Methods and Results -A total of 1242 consecutive asymptomatic patients free of clinical coronary heart disease were studied by electron-beam computed tomography for the extent of calcium due to atherosclerosis in 5 distinct vascular beds and calcium in the aortic and mitral annuli. Nearly 24%had calcium in the aortic annulus, whereas 8%were found to have mitral annular calcification. Age and a history of hypertension were the only traditional cardiovascular risk factors that were independently associated with prevalent calcification in the aortic and mitral annuli. After adjustment for age, gender, and cardiovascular disease risk factors, subjects with calcium in the thoracic aorta had the highest odds for the presence of aortic annular calcium(OR=3.9, P< 0.01), whereas those with calcium in the abdominal aorta had the highest odds for mitral annular calcification(OR=5.1, P=0.01). Standardized increases in calcium in the abdominal aorta(OR=2.0, P< 0.01) and iliacs(OR=1.8, P=0.01) were significantly associated with calcium in the aortic annulus after adjustment for the extent of calcium in the other vascular beds, whereas the thoracic aorta was significantly associated(OR=1.4, P=0.02) with calcium in the mitral annulus. Conclusions -This study supports the hypothesis that calcification of the mitral and aortic annuli is related to atherosclerosis in other vascular beds.
文摘目的探讨阻塞性睡眠呼吸暂停(OSA)与急性冠状动脉综合征(ACS)患者冠状血管病变程度的相关性。方法选取2019年5-12月该院心内科收治的ACS住院患者220例,采用Watch PAT 200 TM完成床边睡眠呼吸监测。根据呼吸暂停低通气指数(AHI)分为OSA组(AHI>15,n=139)和对照组(AHI≤15,n=81)。收集2组患者一般临床资料及睡眠监测资料,分析OSA与ACS患者冠状血管病变程度的相关性。结果OSA组患者体重指数[(25.2±3.3)kg/m^(2)]、钙化半定量积分[(2.7±1.4)分]均明显高于对照组[分别为(24.2±3.2)kg/m^(2)、(2.3±1.4)分],差异均有统计学意义(P<0.05);AHI与冠状动脉钙化半定量积分呈正相关(r=0.142,P=0.035)。结论ACS患者合并OSA所占比例较高,且其冠状血管钙化程度更高。
