Protein tyrosine phosphatases(PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. Recepto...Protein tyrosine phosphatases(PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. Receptor-type protein tyrosine phosphatases(PTPRs) are a subgroup of PTPs that share a transmembrane domain with resulting similarities in function and target specificity. In this review, we summarize genetic and epigenetic alterations including mutation, deletion, amplification, and promoter methylation of PTPRs in cancer and consider the consequences of PTPR alterations in different types of cancers. We also summarize recent developments using PTPRs as prognostic or predictive biomarkers and/or direct targets. Increased understanding of the role of PTPRs in cancer may provide opportunities to improve therapeutic approaches.展开更多
The mammalian target of rapamycin,mTOR,forms various protein-protein complexes to regulate cell growth in response to the nutrient and energy status of the cell.Recently,the first crystal structure of large HEAT repea...The mammalian target of rapamycin,mTOR,forms various protein-protein complexes to regulate cell growth in response to the nutrient and energy status of the cell.Recently,the first crystal structure of large HEAT repeat protein mTOR revealed that the FAT domain interacts with the kinase domain through electrostatic effects and hydrophobic interactions.Based on the structure,the previous researches on how FAT domain regulates mTOR activity are reviewed.DEPTOR is currently known as an endogenous mTOR inhibitor,which may interact with mTOR FAT domain to suppress mTOR activity in vivo.The possible interactions of DEPTOR with the mTOR FAT domain are analyzed,too.In addition,the inhibition mechanism of DEPTOR may be similar to members of HEAT-involved RanGTP complex family,providing new mechanistic insights into mTOR kinase regulation.展开更多
近日,中国水稻研究所种质创新团队在Plant Biotechnolgy Journal在线发表了题为OsACL-A2negatively regulates cell death and disease resistance in rice的论文,揭示了ATP-柠檬酸裂解酶A2亚基参与了水稻细胞凋亡和抗病反应。
2018年9月21日,黎家课题组阐述了受体激酶（Receptor-like protein kinases,RLKs）在拟南芥根毛形成及其顶端生长过程中的重要作用。近年来,多个RLKs被发现在根毛的生长发育过程中也起着至关重要的作用。在拟南芥中,根表皮细胞的分化是...2018年9月21日,黎家课题组阐述了受体激酶（Receptor-like protein kinases,RLKs）在拟南芥根毛形成及其顶端生长过程中的重要作用。近年来,多个RLKs被发现在根毛的生长发育过程中也起着至关重要的作用。在拟南芥中,根表皮细胞的分化是由其位置决定的：只有与2个皮层细胞相接触的表皮细胞可以分化形成根毛细胞.展开更多
基金This work was supported by the grants of the key project on scientifictechnological researchfrom the Ministry of Education (03098)the‘Thousand-hundred-ten project’cultivating excellent person-nel from the Department of Education of Guangdong pr
文摘Protein tyrosine phosphatases(PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. Receptor-type protein tyrosine phosphatases(PTPRs) are a subgroup of PTPs that share a transmembrane domain with resulting similarities in function and target specificity. In this review, we summarize genetic and epigenetic alterations including mutation, deletion, amplification, and promoter methylation of PTPRs in cancer and consider the consequences of PTPR alterations in different types of cancers. We also summarize recent developments using PTPRs as prognostic or predictive biomarkers and/or direct targets. Increased understanding of the role of PTPRs in cancer may provide opportunities to improve therapeutic approaches.
基金supported by the National Natural Science Foundation of China(21133003,21273023)Specialized Research Fund for the Doctoral Program of Higher Education(20110003120013)
文摘The mammalian target of rapamycin,mTOR,forms various protein-protein complexes to regulate cell growth in response to the nutrient and energy status of the cell.Recently,the first crystal structure of large HEAT repeat protein mTOR revealed that the FAT domain interacts with the kinase domain through electrostatic effects and hydrophobic interactions.Based on the structure,the previous researches on how FAT domain regulates mTOR activity are reviewed.DEPTOR is currently known as an endogenous mTOR inhibitor,which may interact with mTOR FAT domain to suppress mTOR activity in vivo.The possible interactions of DEPTOR with the mTOR FAT domain are analyzed,too.In addition,the inhibition mechanism of DEPTOR may be similar to members of HEAT-involved RanGTP complex family,providing new mechanistic insights into mTOR kinase regulation.
文摘近日,中国水稻研究所种质创新团队在Plant Biotechnolgy Journal在线发表了题为OsACL-A2negatively regulates cell death and disease resistance in rice的论文,揭示了ATP-柠檬酸裂解酶A2亚基参与了水稻细胞凋亡和抗病反应。
文摘2018年9月21日,黎家课题组阐述了受体激酶（Receptor-like protein kinases,RLKs）在拟南芥根毛形成及其顶端生长过程中的重要作用。近年来,多个RLKs被发现在根毛的生长发育过程中也起着至关重要的作用。在拟南芥中,根表皮细胞的分化是由其位置决定的：只有与2个皮层细胞相接触的表皮细胞可以分化形成根毛细胞.
