Background:Anatomical and histopathologic correlates of the unique dermoscopic patterns seen in melanocytic nevi on acral volar skin is yet to be clarified. Objective:Our aim was to investigate the relation between th...Background:Anatomical and histopathologic correlates of the unique dermoscopic patterns seen in melanocytic nevi on acral volar skin is yet to be clarified. Objective:Our aim was to investigate the relation between the dermoscopic patterns and anatomical and histopathological characteristics of melanocytic nevi on the sole. Methods:The precise locations of 298 melanocytic nevi on the sole from 278 patients were retrospectively investigated, with attention paid to each dermoscopic pattern. In addition, 35 nevi showing each typical dermoscopic pattern were excised and evaluated histopathologically. Results:Melanocytic nevi showing the parallel furrow pattern or the fibrillar pattern were located on the portions of the sole with regular parallel skin markings and were not found on the arch areas of the foot. Moreover, a subtle but distinctive difference in the distribution was observed between nevi of the two patterns; the nevi with the fibrillar pattern showed a tendency for the sites directly pressed by the body’s weight. Melanocytic nevi of the lattice-like pattern were mostly located on the arch areas. Histopathologically,irrespective of the dermoscopic patterns,nests of nevus cells were mainly located in the epidermal rete ridges underlying the surface sulci. In the nevi with a fibrillar pattern, the cornified layer showed a slanting arrangement, which is considered to be a histopathological background of the fibrillar pattern. Conclusion:Dermoscopic patterns seen in acral melanocytic nevi could be explained by the unique anatomical and histopathological characteristics of the acral skin.展开更多
The main epiluminescence microscopy (ELM) patterns observed on volar acquired melanocytic naevi are the parallel-furrow, the lattice-like and the fibrillar patterns. Because of the peculiar arrangement and configurati...The main epiluminescence microscopy (ELM) patterns observed on volar acquired melanocytic naevi are the parallel-furrow, the lattice-like and the fibrillar patterns. Because of the peculiar arrangement and configuration of epidermal rete ridges in the glabrous skin, the traditional histological picture does not provide an exact correlation with ELM features. In particular, the fibrillar pattern lacks a histopathological correlate. To clarify the microscopic features of the fibrillar pattern, we used transverse histological sectioning to study an acquired compound melanocytic naevus of the sole, characterized by a mixedparallel-furrow/fibrillar pattern on ELM. Low-magnificati-on images of transverse sections allowed us to highlight the typical anatomical arrangement of the volar skin clearly, while high-magnification images demonstrated that the fibrillar pattern corresponded to parallel striae of intensely pigmented corneocytes arranged obliquely to the cutaneous surface.展开更多
文摘Background:Anatomical and histopathologic correlates of the unique dermoscopic patterns seen in melanocytic nevi on acral volar skin is yet to be clarified. Objective:Our aim was to investigate the relation between the dermoscopic patterns and anatomical and histopathological characteristics of melanocytic nevi on the sole. Methods:The precise locations of 298 melanocytic nevi on the sole from 278 patients were retrospectively investigated, with attention paid to each dermoscopic pattern. In addition, 35 nevi showing each typical dermoscopic pattern were excised and evaluated histopathologically. Results:Melanocytic nevi showing the parallel furrow pattern or the fibrillar pattern were located on the portions of the sole with regular parallel skin markings and were not found on the arch areas of the foot. Moreover, a subtle but distinctive difference in the distribution was observed between nevi of the two patterns; the nevi with the fibrillar pattern showed a tendency for the sites directly pressed by the body’s weight. Melanocytic nevi of the lattice-like pattern were mostly located on the arch areas. Histopathologically,irrespective of the dermoscopic patterns,nests of nevus cells were mainly located in the epidermal rete ridges underlying the surface sulci. In the nevi with a fibrillar pattern, the cornified layer showed a slanting arrangement, which is considered to be a histopathological background of the fibrillar pattern. Conclusion:Dermoscopic patterns seen in acral melanocytic nevi could be explained by the unique anatomical and histopathological characteristics of the acral skin.
文摘The main epiluminescence microscopy (ELM) patterns observed on volar acquired melanocytic naevi are the parallel-furrow, the lattice-like and the fibrillar patterns. Because of the peculiar arrangement and configuration of epidermal rete ridges in the glabrous skin, the traditional histological picture does not provide an exact correlation with ELM features. In particular, the fibrillar pattern lacks a histopathological correlate. To clarify the microscopic features of the fibrillar pattern, we used transverse histological sectioning to study an acquired compound melanocytic naevus of the sole, characterized by a mixedparallel-furrow/fibrillar pattern on ELM. Low-magnificati-on images of transverse sections allowed us to highlight the typical anatomical arrangement of the volar skin clearly, while high-magnification images demonstrated that the fibrillar pattern corresponded to parallel striae of intensely pigmented corneocytes arranged obliquely to the cutaneous surface.
