Duffy抗原,是Cutbush在1950年发现一名叫Duffy的输血后产生了溶血反应患者,在该患者血浆中发现了抗Fya抗体,之后确认了Fya抗原的存在。到1993年,确认了Fy基因的位点。1991年Daybomme等证实了Duffy抗原是红细胞膜上CC家族和CXC家族趋化...Duffy抗原,是Cutbush在1950年发现一名叫Duffy的输血后产生了溶血反应患者,在该患者血浆中发现了抗Fya抗体,之后确认了Fya抗原的存在。到1993年,确认了Fy基因的位点。1991年Daybomme等证实了Duffy抗原是红细胞膜上CC家族和CXC家族趋化因子的杂项趋化因子的受体,是红细胞上的趋化因子受体,也称为达菲抗原/趋化因子受体（Duffy.Antigen/Receptor for Chemokines,DARC）2010年,国际输血协会（ISBT）确认了Duffy血型系统有5个抗原，命名为Fy1，Fy2，Fy3，Fy5，Fy6（传统名：Fya，Fyb，Fy3，Fy5，Fy6）。展开更多
Recent evidence suggests that the chemokine axis of CXC chemokine ligand-12 and its receptor CXC chemokine receptor-4(CXCL12/CXCR4) is highly expressed in gynecological tumors and the axis of CXC chemokine ligand-16 a...Recent evidence suggests that the chemokine axis of CXC chemokine ligand-12 and its receptor CXC chemokine receptor-4(CXCL12/CXCR4) is highly expressed in gynecological tumors and the axis of CXC chemokine ligand-16 and CXC chemokine receptor-6(CXCL16/CXCR6) is overexpressed in inflammation-associated tumors.This study aimed to determine the relationship between CXCL12/CXCR4,CXCL16/CXCR6 and ovarian carcinoma's clinicopathologic features and prognosis.Accordingly,the expression of these proteins in ovarian tissues was detected by tissue microarray and immunohistochemistry.The expressions of CXCL12/CXCR4 and CXCL16/CXCR6 were significantly higher in epithelial ovarian carcinomas than in normal epithelial ovarian tissues or benign epithelial ovarian tumors.The expression of chemokines CXCL12 and CXCL16 were positively correlated with their receptors CXCR4 and CXCR6 in ovarian carcinoma,respectively(r = 0.300,P < 0.05;r = 0.395,P < 0.05).Moreover,the expression of CXCL12 was related to the occurrence of ascites(χ2 = 4.76,P < 0.05),the expression of CXCR4 was significantly related to lymph node metastasis(χ2 = 4.37,P < 0.05),the expression of CXCR6 was significantly related to lymph node metastasis(χ2 = 7.43,P < 0.05) and histological type(χ2 = 33.48,P < 0.05).In univariate analysis,the expression of CXCR4 and CXCL16 significantly correlated with reduced median survival(χ2 = 4.67,P < 0.05;χ2 = 4.48,P < 0.05).Therefore,we conclude that the chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 may play important roles in the growth,proliferation,invasion,and metastasis of epithelial ovarian carcinoma.展开更多
文摘Duffy抗原,是Cutbush在1950年发现一名叫Duffy的输血后产生了溶血反应患者,在该患者血浆中发现了抗Fya抗体,之后确认了Fya抗原的存在。到1993年,确认了Fy基因的位点。1991年Daybomme等证实了Duffy抗原是红细胞膜上CC家族和CXC家族趋化因子的杂项趋化因子的受体,是红细胞上的趋化因子受体,也称为达菲抗原/趋化因子受体（Duffy.Antigen/Receptor for Chemokines,DARC）2010年,国际输血协会（ISBT）确认了Duffy血型系统有5个抗原，命名为Fy1，Fy2，Fy3，Fy5，Fy6（传统名：Fya，Fyb，Fy3，Fy5，Fy6）。
基金supported by grants from NationalNatural Science Foundation for Young Scholars of China(No. 30700763)Promotive Research Foundation forExcellent Young and Middle-aged Scientists of Shandong(No. BS2009SW002)
文摘Recent evidence suggests that the chemokine axis of CXC chemokine ligand-12 and its receptor CXC chemokine receptor-4(CXCL12/CXCR4) is highly expressed in gynecological tumors and the axis of CXC chemokine ligand-16 and CXC chemokine receptor-6(CXCL16/CXCR6) is overexpressed in inflammation-associated tumors.This study aimed to determine the relationship between CXCL12/CXCR4,CXCL16/CXCR6 and ovarian carcinoma's clinicopathologic features and prognosis.Accordingly,the expression of these proteins in ovarian tissues was detected by tissue microarray and immunohistochemistry.The expressions of CXCL12/CXCR4 and CXCL16/CXCR6 were significantly higher in epithelial ovarian carcinomas than in normal epithelial ovarian tissues or benign epithelial ovarian tumors.The expression of chemokines CXCL12 and CXCL16 were positively correlated with their receptors CXCR4 and CXCR6 in ovarian carcinoma,respectively(r = 0.300,P < 0.05;r = 0.395,P < 0.05).Moreover,the expression of CXCL12 was related to the occurrence of ascites(χ2 = 4.76,P < 0.05),the expression of CXCR4 was significantly related to lymph node metastasis(χ2 = 4.37,P < 0.05),the expression of CXCR6 was significantly related to lymph node metastasis(χ2 = 7.43,P < 0.05) and histological type(χ2 = 33.48,P < 0.05).In univariate analysis,the expression of CXCR4 and CXCL16 significantly correlated with reduced median survival(χ2 = 4.67,P < 0.05;χ2 = 4.48,P < 0.05).Therefore,we conclude that the chemokine axes CXCL12/CXCR4 and CXCL16/CXCR6 may play important roles in the growth,proliferation,invasion,and metastasis of epithelial ovarian carcinoma.
