AIM： To investigate the possible role of c-erbB-2 and glutathione S-transferase （GST-Pi） in primary hepatocellular carcinogenesis and the relationship between liver hyperplastic nodule （LHN）, liver cirrhosis （LC...AIM： To investigate the possible role of c-erbB-2 and glutathione S-transferase （GST-Pi） in primary hepatocellular carcinogenesis and the relationship between liver hyperplastic nodule （LHN）, liver cirrhosis （LC）, and hepatocellular carcinoma （HCC）.METHODS： The expression of c-erbB-2 and GST-Pi was detected immunohistochemically in 42 tissue specimens of HCC and 77 specimens of its adjacent tissue.RESULTS： The positive expression of c-erbB-2 in LHN （28.6%） was significantly higher than that in LC （0%） （P = 0.032〈0.05）, but no significant difference was seen between HCC and LHN or LC （P〉0.05, X^2 = 0.002, 3.447）.The positive expression of GST-Pi in HCC （89.6%） or LHN （72.2%） was significantly higher than that in LC（22.9%, P〈0.001, ;X^2= 49.91, 16.96）. There was a significant difference between HCC and LHN （P〈0.05,X^2= 6.353）.CONCLUSION： The c-erbB-2 expression is an early event in the pathogenesis of HCC. GST-Pi may be a marker enzyme for immunohistochemical detection of human HCC and its preneoplastic lesions. LHN seems to be a preneoplastic lesion related to hepatocarcinogenesis.展开更多
基金Supported by the Scientific Research Foundation of Shandong Provincial Education Committee (J94, K26)
文摘AIM： To investigate the possible role of c-erbB-2 and glutathione S-transferase （GST-Pi） in primary hepatocellular carcinogenesis and the relationship between liver hyperplastic nodule （LHN）, liver cirrhosis （LC）, and hepatocellular carcinoma （HCC）.METHODS： The expression of c-erbB-2 and GST-Pi was detected immunohistochemically in 42 tissue specimens of HCC and 77 specimens of its adjacent tissue.RESULTS： The positive expression of c-erbB-2 in LHN （28.6%） was significantly higher than that in LC （0%） （P = 0.032〈0.05）, but no significant difference was seen between HCC and LHN or LC （P〉0.05, X^2 = 0.002, 3.447）.The positive expression of GST-Pi in HCC （89.6%） or LHN （72.2%） was significantly higher than that in LC（22.9%, P〈0.001, ;X^2= 49.91, 16.96）. There was a significant difference between HCC and LHN （P〈0.05,X^2= 6.353）.CONCLUSION： The c-erbB-2 expression is an early event in the pathogenesis of HCC. GST-Pi may be a marker enzyme for immunohistochemical detection of human HCC and its preneoplastic lesions. LHN seems to be a preneoplastic lesion related to hepatocarcinogenesis.
基金The Program of Tianjin Municipal Science&Technology Project(11ZCZDSY08100)The Program of“One Hundred Talented People”of the Chinese Academy of Sciences(KSCW2-YW-BR-4)National Natural Science Foundation of China(81273275)~~
